scholarly journals Using Fuzzy Logic to Adjust Plasma Concentration Based on a Two-Compartment Pharmacokinetic Model

2013 ◽  
Vol 341-342 ◽  
pp. 1171-1174
Author(s):  
Lei Zhao ◽  
Xin Ling Shi ◽  
Yu Feng Zhang ◽  
Ya Jie Liu
Keyword(s):  
Fuzzy Logic ◽  
Pharmacokinetic Model ◽  
Fuzzy Controller ◽  
Reference Value ◽  
Rule Base ◽  
Loop Control ◽  
Closed Loop Control System ◽  
Loop Control System ◽  
Input Variables ◽  
Adaptation Scheme

In this paper, a closed-loop control system was developed using fuzzy logic to adapt the parameters of a pharmacokinetic (PK) model. The system is based on a two-compartment PK model with first-order rate process of oral administration. The fuzzy logic adaptation scheme uses the error and the change in error as the input variables. The output variable of the fuzzy controller is the scaling factor to adjust the PK parameter. The fuzzy controller adjusted the real situation concentration to the reference value derived from the parameters of population mean data according to the established rule-base. The simulation results show that the controller provides good performance to adjust the concentration with the reference values.

An Expert Controller Based on Transient Response Patterns

2011 ◽  
Vol 219-220 ◽  
pp. 3-7
Author(s):  
Ning Zhang ◽  
Rong Hua Liu
Keyword(s):  
Control System ◽  
Transient Response ◽  
Closed Loop ◽  
Performance Criterion ◽  
Response Patterns ◽  
Loop Control ◽  
Expert Control ◽  
Closed Loop Control System ◽  
Loop Control System ◽  
Control Decision

An expert control system based on transient response patterns and expert system techniques is proposed in this paper. Depending on the features of the closed-loop control system determines the control decision and adjusts the parameters of the controller. The proposed method requires minimal proper information about the controlled plant and, with the linear re-excitation learning method, the system is kept satisfying the performance criterion.

scholarly journals Closed-loop control system for well-defined oxygen supply in micro-physiological systems

2017 ◽  
Vol 3 (2) ◽  
pp. 363-366
Author(s):  
Tobias Steege ◽  
Mathias Busek ◽  
Stefan Grünzner ◽  
Andrés Fabían Lasagni ◽  
Frank Sonntag
Keyword(s):  
Control System ◽  
Oxygen Supply ◽  
Closed Loop ◽  
Microfluidic System ◽  
Closed Loop Control ◽  
Loop Control ◽  
Cell Vitality ◽  
Closed Loop Control System ◽  
Loop Control System

AbstractTo improve cell vitality, sufficient oxygen supply is an important factor. A deficiency in oxygen is called Hypoxia and can influence for example tumor growth or inflammatory processes. Hypoxia assays are usually performed with the help of animal or static human cell culture models. The main disadvantage of these methods is that the results are hardly transferable to the human physiology. Microfluidic 3D cell cultivation systems for perfused hypoxia assays may overcome this issue since they can mimic the in-vivo situation in the human body much better. Such a Hypoxia-on-a-Chip system was recently developed. The chip system consists of several individually laser-structured layers which are bonded using a hot press or chemical treatment. Oxygen sensing spots are integrated into the system which can be monitored continuously with an optical sensor by means of fluorescence lifetime detection.Hereby presented is the developed hard- and software requiered to control the oxygen content within this microfluidic system. This system forms a closed-loop control system which is parameterized and evaluated.

The Design and Simulation of Three-Phase PWM Converter

2013 ◽  
Vol 321-324 ◽  
pp. 917-920
Author(s):  
Guang Ya Liu ◽  
Xiao Song Li
Keyword(s):  
High Frequency ◽  
Closed Loop ◽  
Voltage Source ◽  
Pwm Rectifier ◽  
Phase Voltage ◽  
Pwm Converter ◽  
Loop Control ◽  
Closed Loop Control System ◽  
Three Phase ◽  
Loop Control System

Three-phase voltage source PWM rectifier generally adopts double closed loop control system. According to the high frequency characteristic of three-phase voltage source PWM rectifier, this paper put forward the setting method of current inner ring regulator and voltage outer ring regulator PI parameter. Finally, it is verified by simulation.

Closed Loop Identification by Optimization Method

2015 ◽  
Vol 1084 ◽  
pp. 636-641
Author(s):  
Valeriy F. Dyadik ◽  
Nikolay S. Krinitsyn ◽  
Vyacheslav A. Rudnev
Keyword(s):  
Closed Loop ◽  
Uranium Hexafluoride ◽  
Optimization Method ◽  
Model Parameters ◽  
Control Loop ◽  
Loop Control ◽  
Identification Method ◽  
Closed Loop Control System ◽  
Closed Loop Identification ◽  
Loop Control System

The article is devoted to the adaptation of the controller parameters during its operation as a part of a control loop. The possibility to identify the parameters of the controlled plant model in the closed control loop has been proved by a computer simulation. The described active identification method is based on the response processing of the closed loop control system to standard actions. The developed algorithm has been applied to determine the model parameters of the flaming fluorination reactor used for the production of uranium hexafluoride. Designed identification method improves the quality of the product and the efficiency of the entire production.

Adaptive synchronization of uncertain fractional-order chaotic systems using sliding mode control techniques

2019 ◽  
Vol 234 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Bahram Yaghooti ◽  
Ali Siahi Shadbad ◽  
Kaveh Safavi ◽  
Hassan Salarieh
Keyword(s):  
Control System ◽  
Sliding Mode Control ◽  
Fractional Order ◽  
Chaotic Systems ◽  
Closed Loop ◽  
Sliding Mode ◽  
Closed Loop Control ◽  
Loop Control ◽  
Closed Loop Control System ◽  
Loop Control System

In this article, an adaptive nonlinear controller is designed to synchronize two uncertain fractional-order chaotic systems using fractional-order sliding mode control. The controller structure and adaptation laws are chosen such that asymptotic stability of the closed-loop control system is guaranteed. The adaptation laws are being calculated from a proper sliding surface using the Lyapunov stability theory. This method guarantees the closed-loop control system robustness against the system uncertainties and external disturbances. Eventually, the presented method is used to synchronize two fractional-order gyro and Duffing systems, and the numerical simulation results demonstrate the effectiveness of this method.

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