Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation

2000 ◽  
Vol 4 (6) ◽  
pp. 520-525 ◽  
Author(s):  
Tomomi Ikemoto ◽  
Tatsuya Ito ◽  
Hideo Hashimoto ◽  
Tadao Kawarasaki ◽  
Atsuko Nishiguchi ◽  
...  
Keyword(s):  
Large Scale ◽  
Ccr5 Antagonist ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Scale Preparation

ChemInform Abstract: Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation.

ChemInform ◽  
2001 ◽  
Vol 32 (15) ◽  
pp. no-no
Author(s):  
Tomomi Ikemoto ◽  
Tatsuya Ito ◽  
Hideo Hashimoto ◽  
Tadao Kawarasaki ◽  
Atsuko Nishiguchi ◽  
...  
Keyword(s):  
Large Scale ◽  
Ccr5 Antagonist ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Scale Preparation

Highly-Efficient Preparation of Key Intermediate of Huperzine A

2014 ◽  
Vol 484-485 ◽  
pp. 157-160
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

Highly-Efficient Preparation of Key Intermediate of Huperzine A

2013 ◽  
Vol 803 ◽  
pp. 181-184
Author(s):  
Kai Ming Xie
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Potential Application ◽  
Large Scale ◽  
Huperzine A ◽  
Synthetic Route ◽  
Alzheimers Disease ◽  
Highly Efficient ◽  
Large Scale Preparation ◽  
Scale Preparation

Huperzine A was approved for curing Alzheimers disease in the early 1990s in China. We explored a highly-efficient synthetic route for the key intermediate in the total synthesis of this natural product. Only common reagents and conditions were involved. So our new route has potential application in large-scale preparation of the key intermediate.

Synthesis of Soluble Carcerands

2012 ◽  
Vol 1371 ◽  
Author(s):  
Jiménez-Gutiérrez I. Eddy ◽  
Sánchez-Montes K. Erika ◽  
Cortez-Maya Sandra ◽  
Flores-Rojas Gabriel ◽  
Martínez-García Marcos
Keyword(s):  
Elemental Analysis ◽  
Good Yield ◽  
Large Scale ◽  
Synthetic Route ◽  
Large Scale Preparation ◽  
Vis Spectroscopy ◽  
Scale Preparation ◽  
C Nmr ◽  
Oxygen Atoms

ABSTRACTAn efficient synthetic route for the synthesis of carcerands derived from tetramethylchlorocavitands and its tetraesters derivative were synthesized. A large-scale preparation was achieved in good yield. These carcerands are in bridging unit between oxygen atoms, i.e. contains a 3,5 dihydroxybencyl alcohol units. 1H, and 13C NMR in solution, FTIR, UV-vis spectroscopy, MS-FAB+ spectrometry and elemental analysis confirmed the structure of this carcerands.

Purification of the Antihemophilic Factor by Gel Filtration on Agarose

1969 ◽  
Vol 22 (03) ◽  
pp. 577-583 ◽  
Author(s):  
M.M.P Paulssen ◽  
A.C.M.G.B Wouterlood ◽  
H.L.M.A Scheffers
Keyword(s):  
Factor Viii ◽  
Plasma Proteins ◽  
Large Scale ◽  
Gel Filtration ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Antihemophilic Factor

SummaryFactor VIII can be isolated from plasma proteins, including fibrinogen by chromatography on agarose. The best results were obtained with Sepharose 6B. Large scale preparation is also possible when cryoprecipitate is separated by chromatography. In most fractions containing factor VIII a turbidity is observed which may be due to the presence of chylomicrons.The purified factor VIII was active in vivo as well as in vitro.

The occurrence of long chain polyprenols in leaves of plants of Rosaceae family and their isolation by time-extended liquid chromatography

1992 ◽  
Vol 70 (6) ◽  
pp. 448-454 ◽  
Author(s):  
Ewa Świeżewska ◽  
T. Chojnacki ◽  
W. J. Jankowski ◽  
K. Singh ◽  
J. Olsson
Keyword(s):  
Liquid Chromatography ◽  
Fatty Acid ◽  
Large Scale ◽  
Fatty Acid Esters ◽  
Large Scale Preparation ◽  
Scale Preparation ◽  
Wet Weight ◽  
Rosaceae Family ◽  
Acid Esters ◽  
Long Chain

The long chain polyprenols composed of 30 and more isoprene units from leaves of plants belonging to the genera Potentilla and Rosa have been described. They occur in the form of fatty acid esters. The composition of polyprenol mixture was species dependent and its content reached ca. 0.5% wet weight. Large scale preparation of individual polyprenols from a natural polyprenol mixture was performed using time-extended liquid chromatography on the hydrophobic gel Lipidex-5000.Key words: long chain polyprenols, Rosaceae.

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