A Novel Tapered Optical Fiber-Based F0F1-ATPase Nanobiosensor

2014 ◽  
Vol 687-691 ◽  
pp. 3403-3406 ◽  
Author(s):  
Guan Jun Wang ◽  
Zhi Bin Wang
Keyword(s):  
Optical Fiber ◽  
Single Molecule ◽  
Molecular Motor ◽  
High Sensitivity ◽  
Fast Response ◽  
Experimental Results ◽  
Single Molecule Detection ◽  
Multimode Fiber ◽  
Tapered Optical Fiber ◽  
Detection Of Biomolecules

In this paper, a novel high sensitive nanobiosensor based on the combination of F0F1-ATPase molecular motor and Φ100nm tapered optical fiber is described, which as we known has never been reported before. Since the tapered optical fiber tip is well matched with the F0F1-ATPase complex in size, a superb sensitivity is theoretically expected. Experimental results show that this nanobiosensor’s sensitivity is about 3.5 times higher than the result of the experiment conducted on a F0F1-ATPase modified ordinary Φ50μm multimode fiber biosensor. The detecting time could be decreased correspondingly. Therefore a cheap, high sensitivity ,fast response, single molecule detection of biomolecules such as epidemic viruses would be achievable using this tapered optical fiber-based F0F1-ATPase nanobiosensor.

scholarly journals Modification of Higher Alkanes by Nanoparticles to Control Light Propagation in Tapered Fibers

Micromachines ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1006
Author(s):  
Karol A. Stasiewicz ◽  
Iwona Jakubowska ◽  
Joanna Korec ◽  
Katarzyna Matras-Postołek
Keyword(s):  
Optical Fiber ◽  
Light Beam ◽  
Light Propagation ◽  
High Sensitivity ◽  
Fast Response ◽  
Heating Process ◽  
New Materials ◽  
Fiber Sensors ◽  
Tapered Optical Fiber ◽  
Control Light

This study presents the doping of higher alkanes, namely, pentadecane (C15) and hexadecane (C16), with ZnS:Mn nanoparticles to create new types of in-line optical fiber sensors with unique optical properties. In this research, the phenomenon of light beam leakage out of the taper and its interaction with the surrounding materials is described. The fabricated new materials are used as cladding in a tapered optical fiber to make it possible to control the optical light beam. The manufactured sensor shows high sensitivity and fast response to the change in the applied materials. Results are presented for a wide optical range of 1200–1700 nm with the use of a supercontinuum source and an optical spectrum analyzer, as well as for a single wavelength of 800 nm, corresponding to the highest transmitted power. The results present a change in the optical property dependence on the temperature in the cooling and heating process. For all materials, the measurements in a climatic chamber are provided between 0 and 40 °C, corresponding to the phase change of the alkanes from solid to liquid. The addition of nanoparticles to the volume of alkanes is equal to 1 wt%. To avoid a conglomeration of nanoparticles, the anti-agglomeration material, Brij 78 P, is used.

scholarly journals Nanopore Technology for the Application of Protein Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1942
Author(s):  
Xiaoqing Zeng ◽  
Yang Xiang ◽  
Qianshan Liu ◽  
Liang Wang ◽  
Qianyun Ma ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Detection ◽  
High Sensitivity ◽  
Single Molecule Detection ◽  
Sequence Detection ◽  
Fast Detection ◽  
Material Basis ◽  
Sensing Technology ◽  
Detection Technology ◽  
Structure Recognition

Protein is an important component of all the cells and tissues of the human body and is the material basis of life. Its content, sequence, and spatial structure have a great impact on proteomics and human biology. It can reflect the important information of normal or pathophysiological processes and promote the development of new diagnoses and treatment methods. However, the current techniques of proteomics for protein analysis are limited by chemical modifications, large sample sizes, or cumbersome operations. Solving this problem requires overcoming huge challenges. Nanopore single molecule detection technology overcomes this shortcoming. As a new sensing technology, it has the advantages of no labeling, high sensitivity, fast detection speed, real-time monitoring, and simple operation. It is widely used in gene sequencing, detection of peptides and proteins, markers and microorganisms, and other biomolecules and metal ions. Therefore, based on the advantages of novel nanopore single-molecule detection technology, its application to protein sequence detection and structure recognition has also been proposed and developed. In this paper, the application of nanopore single-molecule detection technology in protein detection in recent years is reviewed, and its development prospect is investigated.

scholarly journals Tapered Optical Fiber Sensor for Label-Free Detection of Biomolecules

Sensors ◽  
2011 ◽  
Vol 11 (4) ◽  
pp. 3780-3790 ◽  
Author(s):  
Ye Tian ◽  
Wenhui Wang ◽  
Nan Wu ◽  
Xiaotian Zou ◽  
Xingwei Wang
Keyword(s):  
Optical Fiber ◽  
Optical Fiber Sensor ◽  
Fiber Sensor ◽  
Label Free ◽  
Label Free Detection ◽  
Tapered Optical Fiber ◽  
Detection Of Biomolecules

Label-free detection of biomolecules using a tapered optical fiber sensor

2010 ◽  
Author(s):  
Ye Tian ◽  
Wenhui Wang ◽  
Armand Chery, Jr. ◽  
Nan Wu ◽  
Charles Guthy ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Optical Fiber Sensor ◽  
Fiber Sensor ◽  
Label Free ◽  
Label Free Detection ◽  
Tapered Optical Fiber ◽  
Detection Of Biomolecules

scholarly journals High sensitivity refractive index sensor based on adiabatic tapered optical fiber deposited with nanofilm by ALD

2015 ◽  
Vol 23 (11) ◽  
pp. 13880 ◽  
Author(s):  
Shan Zhu ◽  
Fufei Pang ◽  
Sujuan Huang ◽  
Fang Zou ◽  
Yanhua Dong ◽  
...  
Keyword(s):  
Refractive Index ◽  
Optical Fiber ◽  
High Sensitivity ◽  
Refractive Index Sensor ◽  
Tapered Optical Fiber

An electronic enzyme-linked immunosorbent assay platform for protein analysis based on magnetic beads and AlGaN/GaN high electron mobility transistors

The Analyst ◽  
2020 ◽  
Vol 145 (7) ◽  
pp. 2725-2730 ◽  
Author(s):  
Jin Wang ◽  
Zhiqi Gu ◽  
Xinsheng Liu ◽  
Lei Zhao ◽  
Huoxiang Peng ◽  
...  
Keyword(s):  
Electron Mobility ◽  
Magnetic Beads ◽  
High Sensitivity ◽  
High Electron Mobility Transistors ◽  
High Electron Mobility Transistor ◽  
Fast Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
High Electron ◽  
High Electron Mobility ◽  
Detection Of Biomolecules

The AlGaN/GaN high electron mobility transistor (HEMT) biosensors have the characteristics of high sensitivity, stability and fast response in the detection of biomolecules.

scholarly journals A microfluidic chip-compatible bioassay based on single-molecule detection with high sensitivity and multiplexing

Lab on a Chip ◽  
2010 ◽  
Vol 10 (7) ◽  
pp. 843 ◽  
Author(s):  
Randall E. Burton ◽  
Eric J. White ◽  
Ted R. Foss ◽  
Kevin M. Phillips ◽  
Robert H. Meltzer ◽  
...  
Keyword(s):  
Single Molecule ◽  
Microfluidic Chip ◽  
High Sensitivity ◽  
Single Molecule Detection

scholarly journals Liquid crystal cell with a tapered optical fiber as an active element to optical applications

2019 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
Joanna Ewa Moś ◽  
Karol Antoni Stasiewicz ◽  
Leszek Roman Jaroszewicz
Keyword(s):  
Liquid Crystal ◽  
Optical Fiber ◽  
Optical Fibers ◽  
Fiber Optic ◽  
High Sensitivity ◽  
Single Mode ◽  
Fiber Optic Sensors ◽  
Liquid Crystal Cell ◽  
Crystal Cell ◽  
Tapered Optical Fiber

The work describes the technology of a liquid crystal cell with a tapered optical fiber as an element providing light. The tapered optical fiber with the total optical loss of 0.22 ± 0.07 dB, the taper waist diameter of 15.5 ± 0.5 μm, and the elongation of 20.4 ± 0.3 mm has been used. The experimental results are presented for a liquid crystal cell filled with a mixture 1550* for parallel orientation of LC molecules to the cross section of the taper waist. Measurement results show the influence of the electrical field with voltage in the range of 0-200 V, without, as well as with different modulation for spectral characteristics. The sinusoidal and square signal shapes are used with a 1-10 Hz frequency range. Full Text: PDF ReferencesZ. Liu, H. Y. Tam, L. Htein, M. L.Vincent Tse, C. Lu, "Microstructured Optical Fiber Sensors", J. Lightwave Technol. 35, 16 (2017). CrossRef T. R. Wolinski, K. Szaniawska, S. Ertman1, P. Lesiak, A. W. Domański, R. Dabrowski, E. Nowinowski-Kruszelnicki, J. 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Jaroszewicz, "In-Line Tunable Nematic Liquid Crystal Fiber Optic Device", J. of Lightwave Technol. 36, 4 (2017). CrossRef J. Moś, K A Stasiewicz, K Garbat, P Morawiak, W Piecek, L R Jaroszewicz, "Tapered fiber liquid crystal hybrid broad band device", Phys. Scripta. 93, 12 (2018). CrossRef Ch. Veilleux, J. Lapierre, J. Bures, "Liquid-crystal-clad tapered fibers", Opt. Lett. 11, 11 (1986). CrossRef R. Dąbrowski, K. Garbat, S. Urban, T.R. Woliński, J. Dziaduszek, T. Ogrodnik, A,Siarkowska, "Low-birefringence liquid crystal mixtures for photonic liquid crystal fibres application", Liq. Cryst. 44, (2017). CrossRef S. Lacroix, R. J. Black, Ch. Veilleux, J. Lapierre, "Tapered single-mode fibers: external refractive-index dependence", Appl. Opt., 25, 15 (1986). CrossRef J.F. Henninot, D. Louvergneaux , N.Tabiryan, M. Warenghem, "Controlled Leakage of a Tapered Optical Fiber with Liquid Crystal Cladding", Mol. Cryst.and Liq.Cryst., 282, 1(1996). CrossRef

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