Molecularly Imprinted Polymer Microspheres Prepared by Precipitation Polymerization for Atenolol Recognition

2010 ◽  
Vol 148-149 ◽  
pp. 1192-1198 ◽  
Author(s):  
Jin Yang Yu ◽  
Xiao Ling Hu ◽  
Ren Yuan Song ◽  
Shan Xi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Binding Capacity ◽  
Precipitation Polymerization ◽  
Acetonitrile Solution ◽  
Template Molecule ◽  
Affinity Binding ◽  
Polymer Microspheres ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Molecularly imprinted polymer microspheres for selective binding and recognition of atenolol were prepared by means of precipitation polymerization method using methacylic acid as functional monomer and trimethylolpropane trimethacrylate as cross-linker in the presence of atenolol as template molecule in acetonitrile solution. Computer simulation was employed to demonstrate the mechanism of the interaction between methacylic acid and atenolol. The scanning electron microscopy exhibited that the polymers were uniform spheres with the diameter of about 0.6µm. The adsorption properties of atenolol for imprinted microspheres were evaluated by equilibrium rebinding experiments. Scatchard plot analysis revealed that there were two classes of binding sites in the imprinted microspheres. The dissociation constant and the apparent maximum binding capacity were 4.56×10-4mol/L and 186.46μmol/g for the high affinity binding sites, 2.40×10-2mol/L and 4.01mmol/g for the low affinity binding sites. Compared to the structrally analogues, the imprinted microspheres exhibited a high selective reconizable capacity towards the template.

scholarly journals Removal of bisphenol A from aqueous media using a highly selective adsorbent of hybridization cyclodextrin with magnetic molecularly imprinted polymer

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
S. Mamman ◽  
F. B. M. Suah ◽  
M. Raaov ◽  
F. S. Mehamod ◽  
S. Asman ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Molecularly Imprinted Polymer ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Resonance Spectroscopy ◽  
Template Molecule ◽  
Order Kinetic ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer

In this study, a unique magnetic molecularly imprinted polymer (MMIP) adsorbent towards bisphenol A (BPA) as a template molecule was developed by bulk polymerization using β-cyclodextrin (β-CD) as a co-monomer with methacrylic acid (MAA) to form MMIP MAA–βCD as a new adsorbent. β-CD was hybridized with MAA to obtain water-compactible imprinting sites for the effective removal of BPA from aqueous samples. Benzoyl peroxide and trimethylolpropane trimethacrylate were used as the initiator and cross-linker, respectively. The adsorbents were characterized by Fourier transform infrared spectroscopy, scanning electronic microscopy, transmission electron microscopy, vibrating sample magnetometer, Brunauer–Emmett–Teller and X-ray diffraction. 1 H nuclear magnetic resonance spectroscopy was used to characterize the MAA–βCD and BPA–MAA–βCD complex. Several parameters influencing the adsorption efficiency of BPA such as adsorbent dosage, pH of sample solution, contact time, initial concentrations and temperature as well as selectivity and reusability study have been evaluated. MMIP MAA–βCD showed significantly higher removal efficiency and selective binding capacity towards BPA compared to MMIP MAA owing to its unique morphology with the presence of β-CD. The kinetics data can be well described by the pseudo second-order kinetic and Freundlich isotherm and Halsey models best fitted the isotherm data. The thermodynamic studies indicated that the adsorption reaction was a spontaneous and exothermic process. Therefore, MMIP based on the hybrid monomer of MAA–βCD shows good potential of a new monomer in molecularly imprinted polymer preparation and can be used as an effective adsorbent for the removal of BPA from aqueous solutions.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

scholarly journals Molecularly Imprinted Polymer Microspheres Containing Photoswitchable Spiropyran-Based Binding Sites

2013 ◽  
Vol 5 (17) ◽  
pp. 8537-8545 ◽  
Author(s):  
Tibor Renkecz ◽  
Günter Mistlberger ◽  
Marcin Pawlak ◽  
Viola Horváth ◽  
Eric Bakker
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Polymer Microspheres ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Microfluidic Synthesis and Functional Patterning for Advanced Nanotechnology

2010 ◽  
Vol 1260 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Chemical Sensors ◽  
Binding Sites ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Comparative Result ◽  
Molecularly Imprinted ◽  
Optically Transparent

AbstractIn this study, we introduce ‘molecularly imprinted polymer' (MIP) system, which has receptor or binding sites with specific molecular recognitions.Due to the receptor or binding sites in MIP's systems, it can be used for developing bio- or chemical sensors.To fabricate bio-sensors, bio-molecules have been incorporated into MIP's systems as template molecules, but some bio-molecules are sensitive thus denatured during engineering processes.For this reason, bio-sensor fabrications by conventional UV photolithography have shown some limitations.We demonstrate here a photopatterning process, a micromolding in capillary technique (MIMIC) technique, to photopatterning a MIP's system containing a bio-molecule template.The MIMIC technique uses the photo-masks for photopolymerizing MIP's monomer solutions.The photomask is based on silicon rubbers, which are optically transparent and also minimize any damages of sensitive bio-molecules during photo-polymerizations. For visualizing lithographic performances of MIP's systems, we used a fluorescent template molecule to present a comparative result of MIP's photo-cured patterns.It shows a clear different in MIP's patterns with and without the template.We also employed a microfluidic approach to produce micro-sized MIP's particles, which contribute to increase the sensitivity of bio-molecule sensors/devices.

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