Vasodilatation Measurement Using Finger Vascular Images by Near-Infrared Light and Comparison with RH-PAT

Examination of vascular endothelial function can help infer atherosclerosis progression. This study investigated whether vascular visualization by near-infrared (NIR) light can detect vasodilatation after cuff pressure release of the upper arm and what the correlation is between the brightness decrease ratio (R1) corresponding to vasodilation and the reactive hyperemia index (RHI). We obtained finger vascular images of 53 male subjects by photographing NIR light (wavelength 850 nm) transmitted through the middle phalanx of the middle finger with a charge-coupled device camera. The upper arm was compressed for 10 min using a cuff (200 mmHg), and vascular images before and after cuff compression release were obtained. We analyzed the finger vascular images by NIR light and digital pulse volume using endothelial peripheral arterial tonometry (Endo-PAT). We also calculated the average brightness of each vascular image. Using only the data of the ischemic finger, R1 was defined using the average brightness just before cuff release and the minimum average brightness after cuff release. The brightness of vascular images of the ischemic finger decreased after cuff release probably because of vasodilation. We found significant correlation between R1 and the RHI (r = 0.52; P < 0.001). R1 in the lowest RHI quartile was significantly smaller compared to the highest and second-highest RHI quartiles (P < 0.05). Vascular visualization by NIR light can detect vasodilation after cuff release. This is significantly correlated with the RHI on Endo-PAT.

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Catalyst Halogenation Enables Rapid and Efficient Polymerizations with Visible to Near-Infrared Light

10.26434/chemrxiv.12588965 ◽

2020 ◽

Author(s):

Alex Stafford ◽

Dowon Ahn ◽

Emily Raulerson ◽

Kun-You Chung ◽

Kaihong Sun ◽

...

Keyword(s):

Near Infrared ◽

Transient Absorption ◽

Reaction Times ◽

Infrared Light ◽

Structure Property ◽

Light Emitting ◽

Structure Property Relationships ◽

Nir Light ◽

Light Intensities ◽

Emission Quenching

Driving rapid polymerizations with visible to near-infrared (NIR) light will enable nascent technologies in the emerging fields of bio- and composite-printing. However, current photopolymerization strategies are limited by long reaction times, high light intensities, and/or large catalyst loadings. Improving efficiency remains elusive without a comprehensive, mechanistic evaluation of photocatalysis to better understand how composition relates to polymerization metrics. With this objective in mind, a series of methine- and aza-bridged boron dipyrromethene (BODIPY) derivatives were synthesized and systematically characterized to elucidate key structure-property relationships that facilitate efficient photopolymerization driven by visible to NIR light. For both BODIPY scaffolds, halogenation was shown as a general method to increase polymerization rate, quantitatively characterized using a custom real-time infrared spectroscopy setup. Furthermore, a combination of steady-state emission quenching experiments, electronic structure calculations, and ultrafast transient absorption revealed that efficient intersystem crossing to the lowest excited triplet state upon halogenation was a key mechanistic step to achieving rapid photopolymerization reactions. Unprecedented polymerization rates were achieved with extremely low light intensities (< 1 mW/cm<sup>2</sup>) and catalyst loadings (< 50 μM), exemplified by reaction completion within 60 seconds of irradiation using green, red, and NIR light-emitting diodes.

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Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

Journal of Nanomaterials ◽

10.1155/2014/450670 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 19

Author(s):

Mary K. Popp ◽

Imane Oubou ◽

Colin Shepherd ◽

Zachary Nager ◽

Courtney Anderson ◽

...

Keyword(s):

Light Source ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Tumor Volume ◽

Infrared Light ◽

Led Light ◽

Murine Melanoma ◽

Nir Light ◽

Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

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Detection of residual varicose veins with near infrared light in the early period after varicose surgery and near infrared light assisted sclerotherapy

Vascular ◽

10.1177/17085381211051489 ◽

2021 ◽

pp. 170853812110514

Author(s):

Nail Kahraman ◽

Gündüz Yümün ◽

Deniz Demir ◽

Kadir K Özsin ◽

Sadık A Sünbül ◽

...

Keyword(s):

Minimally Invasive ◽

Saphenous Vein ◽

Venous Insufficiency ◽

Near Infrared ◽

Varicose Veins ◽

Infrared Light ◽

Foam Sclerotherapy ◽

Near Infrared Light ◽

Nir Light ◽

Male Patients

Objectives Varicose veins that cannot be seen with the naked eye can be easily detected with Near Infrared (NIR) light. With a minimally invasive procedure performed with NIR light guided, the need for reoperation is reduced, while optimal treatment of venous insufficiency and symptoms is provided. In this study, the detection of residual varicose veins after varicose vein surgery using NIR light and the results of treatment of sclerotherapy were investigated. Methods In this retrospective study, treatment and clinical outcomes of patients’ who underwent NIR light-guided foam sclerotherapy for Clinical-Etiology-Anatomy-Pathophysiology (CEAP) (C1, C2) stage residual varicose veins after surgical varicose treatment between 2014 and 2017 were examined. Data of patients who underwent foam sclerotherapy with NIR light were collected and analyzed. Results A total of 151 patients and 171 lower extremity varicose veins were treated with surgery. 55 (35.7%) of the patients were male, and 96 (62.3%) were female. Their age ranges from 20 to 64, with an average age of 45.38. 4 (2.6%) of the patients had phlebectomy. 137 of patients (90.7%) had ligation of perforated veins, phlebectomy, and great saphenous vein (GSV) stripping, 10 of patients (6.6%) had GSV stripping, perforating vein ligation, phlebectomy, and small saphenous vein (SSV) surgery. No residual leakage was observed in the controls of GSV, SSV, and perforating veins by duplex ultrasonography (DUS). In the first month after varicose surgery, an average of 1.64 ± 1.05 sessions of sclerotherapy was applied to patients with CEAP C1, C2 stage residual varicose veins. 70 patients had one session of sclerotherapy, 37 patients had two sessions of sclerotherapy, 20 patients had three sessions of sclerotherapy, and 11 patients had four sessions of sclerotherapy administrated. The need for complementary therapy was required for all female patients; 13 of the male patients did not require complementary sclerotherapy. While single-session sclerotherapy was applied to most male patients (32 (58.18%), 10 (18.18%) patients received two sclerotherapy sessions. After completing sclerotherapy, 7 (4.63%) patients had superficial venous thrombosis, and 13 (8.60%) patients had hyperpigmentation. Conclusion Surgical treatment is a safe and effective technique in venous insufficiency. Nevertheless, residual varicose veins may remain, and these can be detected noninvasively with NIR light. Foam sclerotherapy with NIR light is a minimally invasive and safe treatment method for small residual varicose veins after the operation. We think that sclerotherapy with NIR light as a complementary treatment is a practical, reliable, and demanding treatment for clinical improvement, especially in female patients.

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Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

Journal of Materials Chemistry B ◽

10.1039/c8tb00651b ◽

2018 ◽

Vol 6 (21) ◽

pp. 3531-3540 ◽

Cited By ~ 23

Author(s):

Jun Xiang ◽

Xia Tong ◽

Feng Shi ◽

Qiang Yan ◽

Bing Yu ◽

...

Keyword(s):

Drug Release ◽

Diblock Copolymer ◽

Near Infrared ◽

Controlled Drug Release ◽

Infrared Light ◽

Upconversion Nanoparticles ◽

Near Infrared Light ◽

Nir Light ◽

Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

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Construction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light

Biomaterials Science ◽

10.1039/c8bm00602d ◽

2018 ◽

Vol 6 (9) ◽

pp. 2460-2471 ◽

Cited By ~ 10

Author(s):

Xiuhua Wang ◽

Lei Tan ◽

Xiangmei Liu ◽

Zhenduo Cui ◽

Xianjin Yang ◽

...

Keyword(s):

Antibacterial Therapy ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light ◽

Nir Light ◽

Penetration Ability ◽

Bacteria Killing

Near infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapidin situdisinfection of bacterially infected artificial implants due to its penetration ability into tissues.

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H2O2/near-infrared light-responsive nanotheronostics for MRI-guided synergistic chemo/photothermal cancer therapy

Nanomedicine ◽

10.2217/nnm-2019-0043 ◽

2019 ◽

Vol 14 (16) ◽

pp. 2189-2207

Author(s):

Yiming Yu ◽

Li Zhang ◽

Miao Wang ◽

Zhe Yang ◽

Leping Lin ◽

...

Keyword(s):

Near Infrared ◽

Tumor Model ◽

Mri Contrast Agent ◽

Infrared Light ◽

Antitumor Effects ◽

Mri Contrast ◽

Nir Light ◽

Nir Laser

Aim: To develop a H2O2/near-infrared (NIR) laser light-responsive nanoplatform (manganese-doped Prussian blue@polypyrrole [MnPB@PPy]) for synergistic chemo/photothermal cancer theranostics. Materials & methods: Doxorubicin (DOX) was loaded onto the surface of polypyrrole shells. The in vitro and in vivo MRI performance and anticancer effects of these nanoparticles (NPs) were evaluated. Results: The MnPB@PPy NPs could not only generate heat under NIR laser irradiation for cancer photothermal therapy but also act as an excellent MRI contrast agent. The loaded DOX could be triggered to release by both NIR light and H2O2 to enhance synergistic therapeutic efficacy. The antitumor effects were confirmed by in vitro cellular cytotoxicity assays and in vivo treatment in a xenograft tumor model. Conclusion: The designed H2O2/NIR light-responsive MnPB@PPy-DOX NPs hold great potential for future biomedical applications.

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A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

Journal of Materials Chemistry B ◽

10.1039/c6tb00730a ◽

2016 ◽

Vol 4 (27) ◽

pp. 4667-4674 ◽

Cited By ~ 31

Author(s):

Hui-Jing Xiang ◽

Min Guo ◽

Lu An ◽

Shi-Ping Yang ◽

Qian-Ling Zhang ◽

...

Keyword(s):

Nitric Oxide ◽

Targeted Delivery ◽

Photothermal Therapy ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light ◽

Nir Light

NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized.

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Near infrared light-driven water oxidation in a molecule-based artificial photosynthetic device using an upconversion nano-photosensitizer

Chemical Communications ◽

10.1039/c5cc05102a ◽

2015 ◽

Vol 51 (65) ◽

pp. 13008-13011 ◽

Cited By ~ 6

Author(s):

Xiaomin Liu ◽

Hung-Cheng Chen ◽

Xianggui Kong ◽

Youlin Zhang ◽

Langping Tu ◽

...

Keyword(s):

Water Oxidation ◽

Near Infrared ◽

Infrared Light ◽

Upconversion Nanoparticles ◽

Near Infrared Light ◽

Photosynthetic System ◽

Nir Light ◽

Artificial Photosynthetic ◽

Novel Concept

A NIR light driven nano-photosensitizer is reported as a novel concept in an artificial photosynthetic system that integrates upconversion nanoparticles with Pt(ii)-porphyrin.

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Axial-Ligand-Cleavable Silicon Phthalocyanines Triggered by Near-Infrared Light toward Design of Photosensitizers for Photoimmunotherapy

10.21203/rs.3.rs-904362/v1 ◽

2021 ◽

Author(s):

Hideo Takakura ◽

Shino Matsuhiro ◽

Masato Kobayashi ◽

Yuto Goto ◽

Mei Harada ◽

...

Keyword(s):

Near Infrared ◽

Axial Ligand ◽

Alkoxy Group ◽

Infrared Light ◽

Photochemical Process ◽

Protonation Reaction ◽

Axial Ligands ◽

Nir Light ◽

Cleavage Efficiency ◽

Silicon Phthalocyanines

Abstract Near-infrared photoimmunotherapy (NIR-PIT) is a novel phototherapy for the treatment of cancer that uses NIR light and conjugates of antibody-IR700, a silicon phthalocyanine photosensitizer. A key feature of NIR-PIT is light-induced axial ligand cleavage of IR700, which finally causes cytotoxicity. Here, we focused on protonation of the axial ligand on the IR700 anion radical during the photochemical process. The Gibbs energy in the protonation reaction of IR700 derivatives with different axial ligands was calculated. These calculations suggested the order of the cleavage efficiency corresponds to the basicity of the axial ligand (i.e. alkoxy > siloxy (IR700) > phenoxy ≈ oxycarbonyl), which was confirmed by the photoirradiation experiments with synthesized compounds. Thus, axial ligand cleavage is significantly dependent on the basicity of the axial ligand. Our findings suggest that PIT reagent with an IR700 derivative bearing alkoxy group would show better efficacy than IR700.

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Ultralow-intensity near infrared light synchronously activated collaborative chemo/photothermal/photodynamic therapy

Biomaterials Science ◽

10.1039/c9bm01607d ◽

2020 ◽

Vol 8 (2) ◽

pp. 607-618 ◽

Cited By ~ 3

Author(s):

Renlu Han ◽

Keqi Tang ◽

Yafei Hou ◽

Jiancheng Yu ◽

Chenlu Wang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light ◽

Nir Light

An ultralow-intensity 808 nm NIR light with 0.25 W cm−2 synchronously activated collaborative Chemo/Photothermal/Photodynamic therapy system was developed.

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