Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers

2011 ◽  
Vol 694 ◽  
pp. 170-174
Author(s):  
Qiang Xia ◽  
Jia Ying Wu
Keyword(s):  
Coenzyme Q ◽  
Correlation Spectroscopy ◽  
Nanostructured Lipid Carriers ◽  
Photon Correlation ◽  
Vis Spectroscopy ◽  
Before And After ◽  
Size Growth ◽  
The Mean ◽  
Stability Results

The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ10 were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ10-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56–6.72. The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.

Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers

2011 ◽  
Vol 236-238 ◽  
pp. 2917-2920 ◽  
Author(s):  
Jia Ying Wu ◽  
Qiang Xia
Keyword(s):  
Particle Size ◽  
Photon Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Nanostructured Lipid Carriers ◽  
High Pressure Homogenization ◽  
Photon Correlation ◽  
Mean Particle Size ◽  
Ophthalmic Preparation ◽  
The Mean

To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.

Preparation and Characterization of Vitamin a Palmitate-Loaded Nanostructured Lipid Carriers as Delivery Systems for Food Products

2011 ◽  
Vol 236-238 ◽  
pp. 1818-1823 ◽  
Author(s):  
Rong Kong ◽  
Qiang Xia ◽  
Guang Yu Liu
Keyword(s):  
Vitamin A ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Food Products ◽  
Storage Conditions ◽  
Correlation Spectroscopy ◽  
Nanostructured Lipid Carriers ◽  
Laser Diffractometry ◽  
Physical And Chemical

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers were prepared by High Pressure Homogenization (HPH) technique. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of VAP-NLCs were studied in details. Preparation and physicochemical properties of VAP lipid nanoparticles were investigated using various analytical equipments such as TEM, photon correlation spectroscopy (PCS), laser diffractometry (LD) and ultraviolet spectrophotometer. The respective optimal HPH pressure and cycles were 70MPa and 5 cycles, so VAP-NLC dispersions under the optimized condition gave rise to the entrapment efficiency (EE) of 99.8%, PI of 0.234, mean diameter of 144±1.7 nm (2% VAP loading capacity). In addition, VAP lipid nanoparticle has a distinct spherical shape, its particle sizes were around 60–330 nm according to VAP contents and zeta potential values -18~-23 mV. Furthermore, the pH of VAP-NLC dispersion was near to 7.0. This study showed that VAP-NLC could hopefully be applied for food products.

Characterization of spectral diffusion by slow-light photon-correlation spectroscopy

2020 ◽  
Vol 101 (16) ◽  
Author(s):  
H. Vural ◽  
J. Maisch ◽  
I. Gerhardt ◽  
M. Jetter ◽  
S. L. Portalupi ◽  
...  
Keyword(s):  
Slow Light ◽  
Photon Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Spectral Diffusion ◽  
Photon Correlation

Charakterisierung von Silika (Aerosil) Hydrosolen durch Photonenkorrelationsspektroskopie / Characterization of Silica(Aerosil)Hydrosols by Photon Correlation Spectroscopy

1979 ◽  
Vol 34 (1) ◽  
pp. 68-75 ◽  
Author(s):  
E. Killmann ◽  
J. Eisenlauer ◽  
P. Kaniut
Keyword(s):  
Diffusion Coefficient ◽  
Data Analysis ◽  
Photon Correlation Spectroscopy ◽  
Silica Particles ◽  
Model System ◽  
Correlation Spectroscopy ◽  
Photon Correlation ◽  
Scattering Angle

Abstract The diffusion of silica(Aerosil)-hydrosols has been studied by photon correlation spectroscopy. For data analysis the method of cumulants, proposed by Koppel, was used. Effects of charge and hydratation of the silica particles and their complicated aggregated structure required an extrapolation to the solconcentration cs = 0 and the scattering angle θ = 0.The described data analysis combined with the methodical proceeding - using Aerosil aggregates as a model system - shows how to evaluate the diffusion coefficient and its normalized variance. These data of characterization are important for many kinds of aggregated particles in technical applied dispersions.

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