Juvenile ossifying fibroma: an analysis of clinico-pathological features in a case series with a literature review

The concept of fibroosseous lesions of bone has evolved over the last several decades and now includes two major entities: fibrous dysplasia and ossifying fibroma. Peripheral cemento-ossifying fibroma is a relatively rare tumour classified between fibroosseous lesions. It predominantly affects adolescents and young adults, with peak prevalence between 10 and 19 yrs. The cemento-ossifying fibroma is a central neoplasm of bone as well as periodontium which has caused considerable controversy because of confusion regarding terminology and the criteria for its diagnosis. The cemento-ossifying fibroma is odontogenic in origin, whereas ossifying fibroma is of bony origin. Lesions histologically similar to peripheral ossifying fibroma have been given various names in existing literature. Therefore, we present and discuss in this paper a series of cases of peripheral cemento-ossifying fibroma emphasizing the differential diagnosis.

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Juvenile ossifying fibroma of the maxillofacial region: analysis of clinico-pathological features and management

Medicina Oral Patología Oral y Cirugia Bucal ◽

10.4317/medoral.24592 ◽

2021 ◽

pp. 0-0

Author(s):

F. Titinchi

Keyword(s):

Ossifying Fibroma ◽

Pathological Features ◽

Maxillofacial Region ◽

Region Analysis ◽

Juvenile Ossifying Fibroma

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Erratum to: “Peripheral Cemento-Ossifying Fibroma: Case Series Literature Review”

Case Reports in Dentistry ◽

10.1155/2013/827247 ◽

2013 ◽

Vol 2013 ◽

pp. 1-1

Author(s):

Esha Verma ◽

ArunKumar Bhimashankar Chakki ◽

Sharanbasappa Chandrashekar Nagaral ◽

Kiran Kumar Ganji

Keyword(s):

Literature Review ◽

Case Series ◽

Ossifying Fibroma

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Malignant Transformation of Ossifying Fibroma into Parosteal Osteosarcoma with High-grade Component: Presentation of an Unusual Case and Review of the Literature

The Open Dentistry Journal ◽

10.2174/1874210601812011059 ◽

2018 ◽

Vol 12 (1) ◽

pp. 1059-1068

Author(s):

Jahan Abtahi ◽

Aida Ajan

Keyword(s):

Literature Review ◽

Unusual Case ◽

Case Reports ◽

Case Series ◽

Ossifying Fibroma ◽

Parosteal Osteosarcoma ◽

High Survival ◽

High Grade ◽

Temporal Fossa ◽

Posterior Maxilla

Background: Parosteal Osteosarcoma of the Jaw (POSJ) is a rare entity that is associated with a high survival rate. Several case reports and case series of POSJ have been published in the literature, but few authors have described development of this tumor by possible transformation from a fibro-osseous neoplasm. Objective: We present a rare occurrence of parosteal osteosarcoma with involvement of the posterior maxilla, orbit floor, and infra-temporal fossa in a 20-year-old man. Furthermore, we performed a literature review regarding clinical, radiological, and histological features; treatment strategies; and etiology/pathophysiology. Methods: A PubMed search yielded a total of 74 articles and the articles were sorted according to their corresponding key area of focus. Results: This was a case of POSJ with high-grade component in the maxillofacial region of a 20-year old male. Co-expression of MDM2 and CDK4 was confirmed. At 2.5-year follow-up, the patient had died. The literature review revealed 18 articles including 20 cases of POSJ. Four cases represent the possible development of this tumor by transformation from a fibro-osseous neoplasm: Two cases of fibrous dysplasia, one case of cemento-ossifying fibroma, and the case of Ossifying Fibroma (OF) in the present study. Conclusion: In conclusion, we found an unusual case of POSJ of the midface in a patient with a previous diagnosis of OF in the same region. To our knowledge, there have been no previous reports of development of POSJ in OF. Furthermore, this is the first described case of high-grade surface osteosarcoma in the craniofacial region.

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Radiotherapy for juvenile ossifying fibroma of the maxillary sinus: Case report and literature review

Head & Neck ◽

10.1002/hed.24811 ◽

2017 ◽

Vol 39 (8) ◽

pp. E81-E84 ◽

Cited By ~ 3

Author(s):

Scott Strickler ◽

Kathryn E. Hitchcock ◽

Peter T. Dziegielewski ◽

William M. Mendenhall

Keyword(s):

Case Report ◽

Literature Review ◽

Maxillary Sinus ◽

Ossifying Fibroma ◽

Juvenile Ossifying Fibroma

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Comparison radical surgery versus conservative surgery to decrease post-operative recurrence in ossifying fibroma: systematic review

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2020031 ◽

2020 ◽

Vol 26 (4) ◽

pp. 44

Author(s):

Marlinda Adham ◽

Dwi Juliana Dewi

Keyword(s):

Systematic Review ◽

Recurrence Rate ◽

Radical Surgery ◽

Case Series ◽

Conservative Surgery ◽

Cochrane Library ◽

Ossifying Fibroma ◽

Retrospective Case ◽

Juvenile Ossifying Fibroma ◽

First Choice

Background: Ossifying fibroma in craniofacial is a rare disease, benign, locally aggressive fibro-osseous tumor. In the recent 2017 WHO classifications, ossifying fibroma divided into 2 type, ossifying fibroma of odontogenic origin and juvenile ossifying fibroma. Choosing the right treatment that can reduce the recurrence rate are particularly challenging. In this systematic review we try to analyse related study to determine the best treatment for ossifying fibroma. Aim: The aim of this review to evaluate best treatment option and analysed level of recurrence in each type of treatment. Method: Collected Juvenile Ossifying Fibroma (JOF) and Ossifying Fibroma (OF) related Article from four different database (PubMed, Scopus, Cochrane Library, and Proquest). Study selection was done by using PRISMA strategy. Result: Eight retrospective case series studies were analyzed. Recurrence rate after surgery was 15.3%, most frequent recurrence occurs in conservative surgery. Recurrence rate after conservative surgery was 19.7%, compared with radical surgery which relatively lower in percentage, with recurrence rate after surgery was 10.6%. Conclusion: Juvenile Ossifying Fibroma, especially Trabecular Juvenile Ossifying Fibroma (TrJOF), show high recurrence percentage comparing other type. The first-choice management for treating OF was surgical approach. Types of surgery choose to depend on the aggressiveness and morbidity of the disease. Radical surgery was proven better to decrease level of recurrence compared with conservative surgery.

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Cannabis-associated arteritis

VASA ◽

10.1024/0301-1526/a000004 ◽

2010 ◽

Vol 39 (1) ◽

pp. 43-53 ◽

Cited By ~ 17

Author(s):

Grotenhermen

Keyword(s):

Systematic Review ◽

Case Reports ◽

Case Series ◽

Cardiovascular Effects ◽

Causative Factor ◽

Cannabis Use ◽

Thromboangiitis Obliterans ◽

Pathological Features ◽

Scientific Support ◽

Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term cannabis arteritis should be avoided until or unless more convincing scientific support is forthcoming.

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