scholarly journals Longitudinal Intravital Imaging of Tumor-Infiltrating Lymphocyte Motility in Breast Cancer Models

2021 ◽  
Vol 24 ◽  
Author(s):  
Inwon Park ◽  
Sujung Hong ◽  
Joon Seok ◽  
Stephani Edwina Lucia ◽  
Eunjoo Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Intravital Imaging ◽  
Tumor Infiltrating Lymphocyte ◽  
Cancer Models ◽  
Lymphocyte Motility

The truncated somatostatin receptor sst5TMD4 stimulates the production of pro-angiogenic factors in in vitro and in vivo breast cancer models

2014 ◽  
Author(s):  
Raul M Luque ◽  
Mario Duran-Prado ◽  
David Rincon-Fernandez ◽  
Marta Hergueta-Redondo ◽  
Michael D Culler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Somatostatin Receptor ◽  
Angiogenic Factors ◽  
Cancer Models

scholarly journals A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 480
Author(s):  
Caitlyn A. Moore ◽  
Zain Siddiqui ◽  
Griffin J. Carney ◽  
Yahaira Naaldijk ◽  
Khadidiatou Guiro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Translational Medicine ◽  
Drug Response ◽  
Drug Approval ◽  
3D Models ◽  
3D Bioprinting ◽  
Effective Evaluation ◽  
Experimental Systems ◽  
Cancer Models

Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

scholarly journals Integrated analyses of murine breast cancer models reveal critical parallels with human disease

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jonathan P. Rennhack ◽  
Briana To ◽  
Matthew Swiatnicki ◽  
Caleb Dulak ◽  
Martin P. Ogrodzinski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Disease ◽  
Cancer Models

scholarly journals The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models

2015 ◽  
Vol 46 (6) ◽  
pp. 2335-2345 ◽  
Author(s):  
JUAN GARONA ◽  
MARINA PIFANO ◽  
ULISES D. ORLANDO ◽  
MARIA B. PASTRIAN ◽  
NANCY B. IANNUCCI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumour Growth ◽  
The Novel ◽  
Cancer Models

scholarly journals Understanding the Impact of 2D and 3D Fibroblast Cultures on In Vitro Breast Cancer Models

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76373 ◽  
Author(s):  
Kyung Eun Sung ◽  
Xiaojing Su ◽  
Erwin Berthier ◽  
Carolyn Pehlke ◽  
Andreas Friedl ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fibroblast Cultures ◽  
Cancer Models ◽  
2D And 3D ◽  
The Impact

Abstract LB168: Blocking SIRPα on myeloid cells synergizes with radiation therapy in mouse breast cancer models

2021 ◽  
Author(s):  
Claire Lhuillier ◽  
Maud Charpentier ◽  
Sergio Trombetta ◽  
Sandra Demaria
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Myeloid Cells ◽  
Cancer Models ◽  
Mouse Breast Cancer
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