Murine Membranous Nephropathy: Immunization with α3(IV) Collagen Fragment Induces Subepithelial Immune Complexes and FcγR-Independent Nephrotic Syndrome

Мембранозная нефропатия является иммунологически обусловленной не воспалительной гломерулопатией, имеет прогрессирующее стадийное течение и характеризуется дистрофическими и склеротическими процессами. Мембранозная нефропатия - это поражение почечных клубочков (основные функциональные единицы почек), возникающее вследствие оседания на стенках почечных капилляров иммунных комплексов. Это приводит к утолщению и дальнейшему расслоению базальных мембран и стенок сосудов в клубочках. Основным клиническим проявлением МН является нефротический синдром (отеки по всему телу, наличие белка в моче и высокий холестерин в крови). Membranous nephropathy is an immunologically determined non-inflammatory glomerulopathy, has a progressive stage course and is characterized by dystrophic and sclerotic processes. Membranous nephropathy is a lesion of the renal glomeruli (the main functional units of the kidneys) that occurs due to the settling of immune complexes on the walls of the renal capillaries. This leads to thickening and further delamination of the basal membranes and vascular walls in the glomeruli. The main clinical manifestation of MN is nephrotic syndrome (edema throughout the body, the presence of protein in the urine and high cholesterol in the blood).

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Nephrotic syndrome secondary to alpha-1 antitrypsin deficiency

BMJ Case Reports ◽

10.1136/bcr-2020-240288 ◽

2021 ◽

Vol 14 (3) ◽

pp. e240288

Author(s):

Gabriela F Santos ◽

Paul Ellis ◽

Daniela Farrugia ◽

Alice M Turner

Keyword(s):

Nephrotic Syndrome ◽

Membranous Nephropathy ◽

Clinical Investigation ◽

Genetic Disorder ◽

Clinical Manifestations ◽

Protective Role ◽

Caucasian Woman ◽

Antitrypsin Deficiency ◽

Alpha 1 Antitrypsin Deficiency ◽

Alpha 1 Antitrypsin

We report a 64-year-old caucasian woman diagnosed with membranous nephropathy secondary to alpha-1 antitrypsin deficiency (AATD). AATD is a rare autosomal codominant genetic disorder. Its clinical manifestations are mostly observed in the lungs, with early-onset emphysema. Nephropathy due to AATD is still very rare and only a few cohort studies have been reported. It has been recognised that alpha-1 antitrypsin has a protective role in the kidneys which enhances the possibility of development of kidney failure, such as nephrotic syndrome, in cases of AATD. Further clinical investigation is needed to understand the relationship between the development of nephropathy, namely membranous nephropathy, and AATD.

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A CASE OF MEMBRANOUS NEPHROPATHY IN WHICH GASTRECTOMY FOR A GASTRIC CANCER LED TO A REMISSION OF NEPHROTIC SYNDROME

The journal of the Japanese Practical Surgeon Society ◽

10.3919/ringe1963.58.1864 ◽

1997 ◽

Vol 58 (8) ◽

pp. 1864-1868 ◽

Cited By ~ 1

Author(s):

Kentaro EMOTO ◽

Tadateru TAKAHASHI ◽

Yoshitaka KATO ◽

Takayuki NOMIMURA ◽

Ichiro OMORI ◽

...

Keyword(s):

Gastric Cancer ◽

Nephrotic Syndrome ◽

Membranous Nephropathy

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Idiopathic Nephrotic Syndrome: Proliferative Nephropathy and Membranous Nephropathy

Persistent Renal-Genitourinary Disorders ◽

10.1007/978-1-4613-2339-6_1 ◽

1987 ◽

pp. 3-22

Author(s):

Russell W. Chesney ◽

Antonia C. Novello

Keyword(s):

Nephrotic Syndrome ◽

Membranous Nephropathy ◽

Idiopathic Nephrotic Syndrome

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Effect of Prolonged Tacrolimus Treatment in Idiopathic Membranous Nephropathy with Nephrotic Syndrome

Pharmacology ◽

10.1159/000348570 ◽

2013 ◽

Vol 91 (5-6) ◽

pp. 259-266 ◽

Cited By ~ 10

Author(s):

Hang Yuan ◽

Nian Liu ◽

Guang-Dong Sun ◽

Ye Jia ◽

Ping Luo ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Membranous Nephropathy ◽

Idiopathic Membranous Nephropathy

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Immunosuppressive treatment for idiopathic membranous nephropathy in adults with nephrotic syndrome

10.1002/14651858.cd004293 ◽

2003 ◽

Cited By ~ 1

Author(s):

A Schieppati ◽

A Perna ◽

J Zamora ◽

GA Giuliano ◽

N Braun ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Membranous Nephropathy ◽

Immunosuppressive Treatment ◽

Idiopathic Membranous Nephropathy

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Membranous nephropathy

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.210804 ◽

2010 ◽

pp. 3985-3988

Author(s):

Dwomoa Adu

Keyword(s):

Prostate Cancer ◽

Systemic Lupus Erythematosus ◽

Nephrotic Syndrome ◽

Basement Membrane ◽

Autoimmune Diseases ◽

Outer Surface ◽

Glomerular Basement Membrane ◽

Lupus Erythematosus ◽

Membranous Nephropathy ◽

Systemic Lupus

Membranous nephropathy, which accounts for 20 to 30% of cases of the nephrotic syndrome in adults, is defined histologically by the presence of subepithelial immune deposits on the outer surface of the glomerular basement membrane. The immune mechanisms that lead to this are uncertain, and most cases are of unknown cause (idiopathic), but the condition can be associated with autoimmune diseases (systemic lupus erythematosus), malignancy (in 10% of cases, most commonly lung and prostate cancer), drugs, and infections....

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