scholarly journals Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen

2015 ◽  
Vol 194 (6) ◽  
pp. 2673-2682 ◽  
Author(s):  
Motoyasu Onishi ◽  
Koji Ozasa ◽  
Kouji Kobiyama ◽  
Keiichi Ohata ◽  
Mitsutaka Kitano ◽  
...  
Keyword(s):  
Helper Cell ◽  
Local Inflammation ◽  
Cell Responses ◽  
Follicular Helper ◽  
Th2 Cell ◽  
T Follicular Helper Cell

Author response for "Dysregulation in B cell responses and T follicular helper cell function in ADA2 deficiency patients"

2020 ◽  
Author(s):  
Francesca Schena ◽  
Federica Penco ◽  
Stefano Volpi ◽  
Claudia Pastorino ◽  
Roberta Caorsi ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Function ◽  
Author Response ◽  
Helper Cell ◽  
Cell Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
B Cell Responses

Dysregulated expression of miRNAs in immune thrombocytopenia

Epigenomics ◽  
2021 ◽  
Author(s):  
Abdollah Jafarzadeh ◽  
Havva Marzban ◽  
Maryam Nemati ◽  
Sara Jafarzadeh ◽  
Maryam Mahjoubin-Tehran ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Critical Role ◽  
Aberrant Expression ◽  
Cell Responses ◽  
Follicular Helper ◽  
Th2 Cell ◽  
T Follicular Helper Cell ◽  
Immune Thrombocytopenia Purpura ◽  
Th 1

In recent years the critical role of miRNAs has been established in many diseases, including autoimmune disorders. Immune thrombocytopenia purpura (ITP) is a predominant autoimmune disease, in which aberrant expression of miRNAs has been observed, suggesting that miRNAs are involved in its development. miRNAs could induce an imbalance in the T helper (Th)1/Th2 cell and Th17/Treg cell-related responses. Moreover, they could also cause alterations in Th9 and Th22 cell responses, and activate Tfh (T follicular helper) cell-dependent auto-reactive B cells, thus influencing megakaryogenesis. Herein, we summarize the role of immune-related miRNAs in ITP pathogenesis, and look forward to clinical applications.

scholarly journals Targeting the ICOS / ICOS ‐L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease

Allergy ◽  
2018 ◽  
Vol 74 (4) ◽  
pp. 650-662 ◽  
Author(s):  
Faith I. Uwadiae ◽  
Chloe J. Pyle ◽  
Simone A. Walker ◽  
Clare M. Lloyd ◽  
James A. Harker
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Helper Cell ◽  
Cell Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

2017 ◽  
Vol 76 ◽  
pp. 85-100 ◽  
Author(s):  
Florian Wiede ◽  
Faruk Sacirbegovic ◽  
Yew Ann Leong ◽  
Di Yu ◽  
Tony Tiganis
Keyword(s):  
B Cell ◽  
Helper Cell ◽  
Cell Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
B Cell Responses

scholarly journals SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yashavanth Shaan Lakshmanappa ◽  
Sonny R. Elizaldi ◽  
Jamin W. Roh ◽  
Brian A. Schmidt ◽  
Timothy D. Carroll ◽  
...  
Keyword(s):  
Germinal Center ◽  
Viral Infections ◽  
Rhesus Macaques ◽  
Helper Cell ◽  
Nucleocapsid Proteins ◽  
Cell Responses ◽  
Inflammatory Monocytes ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
Induced Immunity

AbstractCD4 T follicular helper (Tfh) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates Tfh cells and stimulates the germinal center (GC) response is an important question as we investigate vaccine induced immunity against COVID-19. Here, we report that SARS-CoV-2 infection in rhesus macaques, either infused with convalescent plasma, normal plasma, or receiving no infusion, resulted in transient accumulation of pro-inflammatory monocytes and proliferating Tfh cells with a Th1 profile in peripheral blood. CD4 helper cell responses skewed predominantly toward a Th1 response in blood, lung, and lymph nodes. SARS-CoV-2 Infection induced GC Tfh cells specific for the SARS-CoV-2 spike and nucleocapsid proteins, and a corresponding early appearance of antiviral serum IgG antibodies. Collectively, the data show induction of GC responses in a rhesus model of mild COVID-19.

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