scholarly journals Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H

2021 ◽  
pp. ji2000398
Author(s):  
Cristina Puy ◽  
Jiaqing Pang ◽  
Stéphanie E. Reitsma ◽  
Christina U. Lorentz ◽  
Erik I. Tucker ◽  
...  
Keyword(s):  
Cross Talk ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Complement Pathway ◽  
Contact Activation ◽  
Factor Xi ◽  
Activation System

scholarly journals Identification of human complement factor H as a chemotactic protein for monocytes

1997 ◽  
Vol 326 (2) ◽  
pp. 377-383 ◽  
Author(s):  
Karim NABIL ◽  
Bertrand RIHN ◽  
Marie-Claude JAURAND ◽  
Jean-Michel VIGNAUD ◽  
Jean RIPOCHE ◽  
...  
Keyword(s):  
Malignant Cell ◽  
Factor H ◽  
Alternative Complement Pathway ◽  
Complement Factor H ◽  
Complement Factor ◽  
Complement Pathway ◽  
Pathway Activation ◽  
Chemotactic Protein ◽  
Alternative Complement ◽  
Cellular Immune

We used chromatographic separation to purify to homogeneity a monomeric monocyte chemotactic protein of 150 kDa contained in mesothelioma pleural effusions. It was identified by N-terminal amino acid sequencing and immunoblotting as complement factor H, an inhibitor of the alternative complement pathway. Specific antibodies against factor H inhibited the monocyte chemotactic activity of the purified protein, which was most active at 10 nM. Factor H is a restrictive factor of alternative complement pathway activation. The new chemotactic function assigned to factor H in recruiting monocytes to the mesothelioma site might contribute to malignant cell phagocytosis via the iC3b/complement receptor type 3 pathway. These functions link the humoral and cellular immune systems.

Disease associated protein complement factor H related protein 1 (CFHR1) is a regulator of the human alternative complement pathway

2008 ◽  
Vol 45 (16) ◽  
pp. 4104 ◽  
Author(s):  
Stefan Heinen ◽  
Ulrike Wiehl ◽  
Nadine Lauer ◽  
Hans-Martin Dahse ◽  
Andrea Hartmann ◽  
...  
Keyword(s):  
Factor H ◽  
Alternative Complement Pathway ◽  
Complement Factor H ◽  
Complement Factor ◽  
Related Protein ◽  
Complement Pathway ◽  
Alternative Complement ◽  
Protein Complement

scholarly journals Contact activation‐induced complex formation between complement factor H and coagulation factor XIIa

2020 ◽  
Vol 18 (4) ◽  
pp. 876-884
Author(s):  
Sai Sindhu Thangaraj ◽  
Stig Hill Christiansen ◽  
Jonas Heilskov Graversen ◽  
Johannes Jakobsen Sidelmann ◽  
Søren Werner Karlskov Hansen ◽  
...  
Keyword(s):  
Complex Formation ◽  
Coagulation Factor ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Contact Activation ◽  
Factor Xiia

Complement factor H R1210C among Japanese patients with age-related macular degeneration

2015 ◽  
Vol 59 (5) ◽  
pp. 273-278 ◽  
Author(s):  
Masahiro Miyake ◽  
Masaaki Saito ◽  
Kenji Yamashiro ◽  
Tetsuju Sekiryu ◽  
Nagahisa Yoshimura
Keyword(s):  
Macular Degeneration ◽  
Japanese Patients ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related

Infection triggered anti complement factor H (CFH) positive atypical Hemolytic Uremic Syndrome in children:  lessons for the clinical nephrologist

2021 ◽  
Author(s):  
Rakesh Kumar Pilania ◽  
Deepanjan Bhattacharya ◽  
Neelam Taneja ◽  
Amit Rawat ◽  
Deepti Suri ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Uremic Syndrome

scholarly journals New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3

2014 ◽  
Vol 34 (5) ◽  
Author(s):  
Elizabeth Rodriguez ◽  
Pavithra M. Rallapalli ◽  
Amy J. Osborne ◽  
Stephen J. Perkins
Keyword(s):  
Alternative Pathway ◽  
Factor H ◽  
Complement Factor H ◽  
Complement C3 ◽  
Complement Factor ◽  
Membrane Cofactor Protein ◽  
Complement Alternative Pathway ◽  
Factor I ◽  
Mutational Hotspots ◽  
Structural Insights

A new compilation of 324 mutations in four major proteins from the complement alternative pathway reveals mutational hotspots in factor H and complement C3, and less so in factor I and membrane cofactor protein. Their associations with function are discussed.

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