scholarly journals Pseudosarcomatous Proliferation of Cx43- and Kit-Expressing Interstitial Cell in the Urinary Bladder

2010 ◽  
Vol 2010 ◽  
pp. 1-6
Author(s):  
Tamotsu Takeuchi ◽  
Masanobu Tanimura ◽  
Tsutomu Shimamoto ◽  
Masaharu Yasuda ◽  
Mutsuo Furihata
Keyword(s):  
Urinary Bladder ◽  
Connexin 43 ◽  
Interstitial Cell ◽  
Muscularis Propria ◽  
Immunohistochemical Analysis ◽  
Mesenchymal Cells ◽  
Histopathological Analysis ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Mass Size

The authors report a case showing proliferation of KIT- and connexin 43-expressing mesenchymal cells of the urinary bladder. A 75-year-old woman had an ulcerated endophytic mass (size, approximately 2 × 2 cm) in the left posterolateral wall. She underwent transurethral resection and subsequent partial cystectomy. The suburothelial mass extended to the muscularis propria. The histopathological analysis revealed spindle-shaped mesenchymal cells that were loosely arranged with myxoid stroma and showed a focal compact fascicular arrangement. In the immunohistochemical analysis, these spindle cells were stained with specific antibodies to KIT and connexin 43. The patient is currently free of disease at 5 years after operation. The proliferating spindle cells in the present case might represent a phenotype of interstitial cells of the lamina propria.

Vulvar Cutaneous Myxoma in a Patient With Carney Complex: Avoiding Pitfalls of Myxoid Lesions of the Vulva

2021 ◽  
pp. 106689692110205
Author(s):  
Jahg Wong ◽  
Simon F. Roy ◽  
Lifeng Gu ◽  
Vanessa Samouelian ◽  
France Berthelet ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Subcutaneous Fat ◽  
Surgical Excision ◽  
Carney Complex ◽  
Lymphocytic Infiltrate ◽  
Histopathological Analysis ◽  
Diagnostic Challenge ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Thin Walled

We present the case of a 31-year-old woman who underwent surgical excision for a polypoid, vulvar lesion. Histopathological analysis showed a diffuse myxoid stroma admixed with scant collagen fibrils. Thin-walled and branching blood vessels were prominent, with a mild perivascular lymphocytic infiltrate. Cytologically bland spindle cells with inconspicuous nucleoli were immersed in a loose myxoid stroma. This combination of histopathological features along with multinodularity in the subcutaneous fat raised concern for deep angiomyxoma, a locally destructive neoplasm. Among our differential of myxoid lesions of the vulva, we ultimately favored the diagnosis of vulvar cutaneous myxoma. Upon further investigation, we learned that our patient was indeed known for the Carney complex. We highlight that vulvar cutaneous myxomas arising in the context of the Carney complex pose a significant diagnostic challenge for pathologists and should not be overdiagnosed as aggressive lesions such as deep angiomyxoma or other malignant stromal neoplasms.

scholarly journals A Synchronous Occurrence of Urothelial Carcinoma with Abundant Myxoid Stroma and Inverted Papilloma of the Urinary Bladder

Rare Tumors ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 145-147 ◽  
Author(s):  
Kemal Behzatoğlu ◽  
Pelin Yildiz ◽  
Meltem Öznur ◽  
Erol R. Bozkurt
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Inverted Papilloma ◽  
Myxoid Stroma

A Carcinosarcoma/Sarcomatoid Carcinoma Arising in a Urinary Bladder Diverticulum

2002 ◽  
Vol 126 (7) ◽  
pp. 853-855 ◽  
Author(s):  
Atilla Omeroglu ◽  
Gladell P. Paner ◽  
Eva M. Wojcik ◽  
Kalliopi Siziopikou
Keyword(s):  
Urinary Bladder ◽  
Sarcomatoid Carcinoma ◽  
High Grade ◽  
Bladder Diverticulum ◽  
Unusual Site ◽  
Muscular Layer ◽  
Spindle Cells ◽  
Aggressive Tumor ◽  
Glandular Structures ◽  
Pleomorphic Cells

Abstract We describe an invasive polypoid carcinosarcoma/sarcomatoid carcinoma arising within a urinary bladder diverticulum in a 65-year-old patient with synchronous, moderately differentiated prostatic adenocarcinoma. Histologically, the diverticular tumor exhibits an admixture of different morphologic components, including invasive high-grade urothelial carcinoma, malignant glandular structures in a cellular background of malignant spindle cells, and areas formed exclusively by spindle and pleomorphic cells. There was full-thickness involvement of the diverticulum with extension of the tumor into the perivesical fat and ipsilateral seminal vesicle. In view of the early invasive behavior of carcinosarcoma/sarcomatoid carcinoma combined with the paucity of the muscular layer in the diverticulum wall, a graver prognosis was expected for this aggressive tumor that occurred in this unusual site.

scholarly journals Morphological assessment of the mucous membranes of the bladder and vagina in chronic cystitis in women

2021 ◽  
pp. 56-64
Author(s):  
I.I. Tityaev ◽  
◽  
K.V. Udalov ◽  
B.I. Aizikovich ◽  
S.V. Savchenko ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Opportunistic Infection ◽  
Microscopic Examination ◽  
Interstitial Cell ◽  
Healthy Tissue ◽  
Chronic Cystitis ◽  
Microcirculatory System ◽  
Mucous Membranes ◽  
Recurrent Cystitis ◽  
Morphological Assessment

The study involved 107 women aged 20 to 52 years with chronic recurrent cystitis (57 of them with leukoplakia) developing under conditions of a pathogenic and/or opportunistic infection. All patients underwent a conventional clinical and instrumental examination. Biopsy samples for culture-based and microscopic examination were taken from the area of the Pawlik’s trigone of the vagina and the Lieutaud’s trigone of the urinary bladder, in case of leukoplakia — from the field of visually healthy tissue. The carried out cytomorphological analysis and assessment of pathological processes in the adjacent tissues suggest that the infection from the vagina penetrates through the intersynaptic clefts, interstitial cell nests, the blood and lymphatic microcirculatory system into the bladder, causing cystitis inherent changes — from initial morphological forms to rough ones, up to leukoplakia. A complex of clinical, functional and pathomorphological changes that fit into the framework of the chronic cystovaginitis concept was identified.

scholarly journals Right Elbow Angioleiomyoma: A Case Report & Review of the Literature

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Corticosteroid Injection ◽  
Standard Of Care ◽  
Surgical Excision ◽  
Upper Extremities ◽  
Histopathological Analysis ◽  
Current Standard ◽  
Smooth Muscle Tumors ◽  
Mass Size ◽  
Case Basis ◽  
Postoperative Observation

Angioleiomyoma are typically benign vascular smooth muscle tumors. These tumors are rarely seen in males as well as the upper extremities. A 49-year-old patient presented with a painful, fluctuant right elbow mass after a 5-6-year latency. In this case, aspiration as well as corticosteroid injection did not diminish mass size or pain caused by it. After exhausting conservative management, the patient opted for surgical excision, debridement, and histopathological analysis for diagnosis and showed the hallmark variable veins within muscular walls. Current standard of care consists of surgical resection and subsequent postoperative observation for local recurrence. Due to its rarity in location and non-specific findings, diagnosis is often unclear. In the context of existing literature, the optimal treatment for these patients should be determined on a case-by-case basis.

DIETARY SOY ISOFLAVONE REPLACEMENT IMPROVES DETRUSOR OVERACTIVITY OF OVARIECTOMIZED RATS WITH ALTERATION OF CONNEXIN-43 EXPRESSION IN THE URINARY BLADDER

2009 ◽  
Vol 181 (4) ◽  
pp. 570
Author(s):  
Shinsuke Okada ◽  
Yoshiyuki Kojima ◽  
Shuzo Hamamoto ◽  
Kentaro Mizuno ◽  
Yasue Kubota ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Detrusor Overactivity ◽  
Connexin 43 ◽  
Ovariectomized Rats ◽  
Soy Isoflavone

scholarly journals A case of planar-type GIST of the sigmoid colon showing diverticular structure with perforation

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Yuka Shintaku ◽  
Yuya Asano ◽  
Takahiro Watanabe ◽  
Takako Kihara ◽  
Eri Ishikawa ◽  
...  
Keyword(s):  
Sigmoid Colon ◽  
Mutational Analysis ◽  
Muscularis Propria ◽  
Normal Mucosa ◽  
Sudden Onset ◽  
Surrounding Tissue ◽  
Spindle Cells ◽  
Japanese Male ◽  
Old Japanese ◽  
Exon 11

Abstract Background Gastrointestinal stromal tumors (GISTs) generally form well-defined mass lesions. However, some cases of the flatly distributed and muscularis propria-replacing GISTs have been reported so far. We experienced an additional case of planar-type GIST of the sigmoid colon accompanied by a diverticulum with perforation. Case presentation A 68-year-old Japanese male with sudden onset of abdominal pain was clinically diagnosed with gastrointestinal perforation, and an emergency abdominal operation was performed. A diverticulum with rupture was found in the sigmoid colon, but no apparent tumor was observed. Histological examination revealed bland spindle cells flatly proliferating and diffusely replacing the muscularis propria at the diverticular structure. The spindle cells were positive for KIT, DOG1, and CD34. Mutational analysis of the c-kit gene revealed that the lesion had a heterozygous deletion of 2 amino acids at codons 557 and 558 of exon 11. The mutation was not observed in the normal mucosa of the surrounding tissue. Conclusion We diagnosed this case as an unusual planar-type GIST. Some similar cases have been reported in the sigmoid colon and other sites. We discuss the mechanism of development of the planar-type GISTs associated with the diverticulum.

scholarly journals Balloon Cell Malignant Melanoma in a Young Female: A Case Report and Review of the Literature

2016 ◽  
Vol 9 (1) ◽  
pp. 262-266 ◽  
Author(s):  
Yui Hattori ◽  
Kazuhiro Sentani ◽  
Takuya Hattori ◽  
Yoshimi Matsuo ◽  
Mikio Kawai ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Immunohistochemical Analysis ◽  
Histopathological Analysis ◽  
Lumbar Region ◽  
Ki 67 ◽  
Complete Replacement ◽  
Clinical Appearance ◽  
Balloon Cells ◽  
Balloon Cell

Balloon cell malignant melanoma (BCMM) is a very rare malignant melanoma subtype. The clinical appearance of BCMM varies; it may be nodular, ulcerated, polypoid, papillomatous and often non-pigmented. The tumor cells histologically appear large, polygonal or round and contain abundant granular or vacuolated cytoplasm. We herein report the case of a 32-year-old female who presented with a focal eccentric pigmented mass in the left lumbar region of 15 mm in diameter that had been present for several years. She underwent tumor excision. The histopathological analysis showed epithelioid melanocytes with clear cytoplasm. An immunohistochemical analysis revealed that the cells were positive for HMB-45 and S-100 protein and negative for cytokeratin. The balloon cell component stained negative for Fontana-Masson. A month later, the patient underwent excision of the bilateral inguinal lymph nodes and metastatic BCMM was revealed. The lymph node metastases showed the complete replacement of lymph nodes by balloon cells. A diagnosis of BCMM (Breslow depth 10 mm, Clark level V) without ulcer was rendered. Staining with Ki-67 was positive in almost 44% of the balloon cells.

scholarly journals Ischemia Alters the Expression of Connexins in the Aged Human Brain

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Taizen Nakase ◽  
Tetsuya Maeda ◽  
Yasuji Yoshida ◽  
Ken Nagata
Keyword(s):  
Gap Junctions ◽  
Connexin 43 ◽  
Immunohistochemical Analysis ◽  
Analysis Data ◽  
Computer Assisted ◽  
Ischemic Insult ◽  
Cx43 Expression ◽  
Neuronal Marker ◽  
Neuronal Markers ◽  
Human Stroke

Although the function of astrocytic gap junctions under ischemia is still under debate, increased expression of connexin 43 (Cx43) has been observed in ischemic brain lesions, suggesting that astrocytic gap junctions could provide neuronal protection against ischemic insult. Moreover, different connexin subtypes may play different roles in pathological conditions. We used immunohistochemical analysis to investigate alterations in the expression of connexin subtypes in human stroke brains. Seven samples, sectioned after brain embolic stroke, were used for the analysis. Data, evaluated semiquantitatively by computer-assisted densitometry, was compared between the intact hemisphere and ischemic lesions. The results showed that the coexpression of Cx32 and Cx45 with neuronal markers was significantly increased in ischemic lesions. Cx43 expression was significantly increased in the colocalization with astrocytes and relatively increased in the colocalization with neuronal marker in ischemic lesions. Therefore, Cx32, Cx43, and Cx45 may respond differently to ischemic insult in terms of neuroprotection.

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