scholarly journals The clinical response of West Nile virus neuroinvasive disease to intravenous immunoglobulin therapy

2012 ◽  
Vol 2 (1) ◽  
pp. 18 ◽  
Author(s):  
Zvi Shimoni ◽  
Hanna Bin ◽  
Shlomo Bulvik ◽  
Mark Niven ◽  
Rawi Hazzan ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Gamma Globulin ◽  
Immunoglobulin Therapy ◽  
Ivig Treatment ◽  
Partial Recovery ◽  
West Nile ◽  
Intravenous Immunoglobulin Therapy ◽  
Neuroinvasive Disease ◽  
Intravenous Gamma Globulin ◽  
Neurological Response

The aim of the study was to determine whether intravenous gamma globulin (IVIG) treatment is effective in patients with West Nile Virus (WNV) neuroinvasive disease. We contacted hospital based infectious disease experts in Israeli hospitals to identify patients with WNV neuroinvasive disease who were treated with IVIG. The main outcome measure was neurological response after treatment. There were 12 patients who received IVIG and four improved within 48 h. Three patients died, 6 had partial recovery, and 3 recovered completely. Eleven of the 12 patients were infected with Israeli genotypes that are highly homologous to Europe/Africa viruses. The rapid response in some patients suggests that IVIG is effective, and might be used to treat patients with WNV neuroinvasive disease with IVIG.

Malignant glial neuronal tumors after west nile virus neuroinvasive disease

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Alyx B Porter ◽  
Akanksha Sharma ◽  
Marie F Grill ◽  
Scott Spritzer ◽  
A Arturo Leis ◽  
...  
Keyword(s):  
West Nile Virus ◽  
West Nile ◽  
Neuroinvasive Disease ◽  
Neuronal Tumors

scholarly journals Animal and Human Vaccines against West Nile Virus

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1073
Author(s):  
Juan-Carlos Saiz
Keyword(s):  
Clinical Trials ◽  
West Nile Virus ◽  
Vaccine Development ◽  
Phase Iii ◽  
West Nile ◽  
Specific Therapy ◽  
Phase Iii Clinical Trials ◽  
Neuroinvasive Disease ◽  
The Us ◽  
The Status

West Nile virus (WNV) is a widely distributed enveloped flavivirus transmitted by mosquitoes, which main hosts are birds. The virus sporadically infects equids and humans with serious economic and health consequences, as infected individuals can develop a severe neuroinvasive disease that can even lead to death. Nowadays, no WNV-specific therapy is available and vaccines are only licensed for use in horses but not for humans. While several methodologies for WNV vaccine development have been successfully applied and have contributed to significantly reducing its incidence in horses in the US, none have progressed to phase III clinical trials in humans. This review addresses the status of WNV vaccines for horses, birds, and humans, summarizing and discussing the challenges they face for their clinical advance and their introduction to the market.

Pediatric West Nile Virus-Associated Neuroinvasive Disease: A Review of the Literature

2019 ◽  
Vol 92 ◽  
pp. 16-25
Author(s):  
Rachelle Herring ◽  
Nilesh Desai ◽  
Mered Parnes ◽  
Imad Jarjour
Keyword(s):  
West Nile Virus ◽  
Review Of The Literature ◽  
West Nile ◽  
Neuroinvasive Disease

scholarly journals Increase in human West Nile and Usutu virus infections, Austria, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Stephan W. Aberle ◽  
Jolanta Kolodziejek ◽  
Christof Jungbauer ◽  
Karin Stiasny ◽  
Judith H. Aberle ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Blood Donation ◽  
Virus Infections ◽  
West Nile Fever ◽  
West Nile ◽  
Usutu Virus ◽  
Neuroinvasive Disease ◽  
Human West Nile Virus ◽  
Imported Cases

Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, six infections detected by blood donation screening and six imported cases. In addition, 18 cases of human Usutu virus infections (all blood donors) were recorded. This is the highest number of annual infections recorded in Austria since the introduction of both viruses.

scholarly journals Human cases of West Nile Virus Infection in north-eastern Italy, 15 June to 15 November 2010

2011 ◽  
Vol 16 (33) ◽  
Author(s):  
L Barzon ◽  
M Pacenti ◽  
R Cusinato ◽  
M Cattai ◽  
E Franchin ◽  
...  
Keyword(s):  
West Nile Virus ◽  
West Nile Virus Infection ◽  
West Nile Fever ◽  
Antibody Prevalence ◽  
Igg Antibody ◽  
West Nile ◽  
The Third ◽  
Neuroinvasive Disease ◽  
Northern Areas ◽  
North Eastern

In 2010, for the third consecutive year, human cases of West Nile virus (WNV) infection, including three confirmed cases of neuroinvasive disease and three confirmed cases of West Nile fever, were identified in north-eastern Italy. While in 2008 and 2009 all human cases of WNV disease were recorded in the south of the Veneto region, cases of WNV disease in 2010 additionally occurred in two relatively small northern areas of Veneto, located outside those with WNV circulation in the previous years. WNV IgG antibody prevalence in blood donors resident in Veneto was estimated as ranging from 3.2 per 1,000 in areas not affected by cases of WNV disease to 33.3 per 1,000 in a highly affected area of the Rovigo province. No further autochthonous human cases of WNV disease were notified in Italy in 2010. The recurrence of human cases of WNV infection for the third consecutive year strongly suggests WNV has become endemic in north-eastern Italy.

Sign in / Sign up

Export Citation Format

Share Document