scholarly journals Interleukin-6 kinetics can be useful for early treatment monitoring of severe bacterial sepsis and septic shock

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Thomas Klag ◽  
Giulio Cantara ◽  
Udo Sechtem ◽  
Anastasios Athanasiadis
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Early Treatment ◽  
Treatment Monitoring ◽  
Bacterial Sepsis ◽  
Case Histories ◽  
Sepsis And Septic Shock ◽  
Kinetics Of

Early appropriate anti-microbial therapy is necessary to improve outcomes of septic patients. We describe 20 case histories of patients with severe bacterial sepsis regarding kinetics of several biomarkers. We found that interleukin-6 is able to predict survival and might be able to evaluate appropriateness of anti-microbial therapy.

scholarly journals Plasma interleukin-6 levels correlate with survival in patients with bacterial sepsis and septic shock

2021 ◽  
Vol 11 (4) ◽  
pp. 224-230
Author(s):  
Monica Chavez Vivas ◽  
Hector Fabio Villamarin Guerrero ◽  
Antonio Jose Tascon ◽  
Augusto Valderrama-Aguirre
Keyword(s):  
Septic Shock ◽  
Cox Regression ◽  
Serum Levels ◽  
Significant Decline ◽  
Bacterial Sepsis ◽  
Inflammatory Biomarker ◽  
Statistical Program ◽  
Sepsis And Septic Shock ◽  
Time Of Admission ◽  
Admission Variables

AbstractIn this study, IL-6 levels were assessed as inflammatory biomarker of bacterial sepsis in patients hospitalized at the ICU of the hospital of Colombia.Materials and methodsProspective study on 62 patients diagnosed with sepsis and septic shock. An ELISA assay was used to test serum levels of IL-6 at admission and 48 h after admission. Variables were analyzed by χ2 test (alfa <0.05). Multivariable Cox regression was used to determine the survival with the statistical program SPSS v23.00.ResultsPatient's median age was 53 years old and 59.7% were male. Lung was the most common primary site of infection (43.5%), and hypertension comorbidity with higher prevalence (40%). Infection by Gram negative bacteria were significantly more frequent among patients than Gram positive (P = 0.037). Overall, survival analysis showed that 10 (16.1%) patients died with a survival median of 7.00 +4.874 (2–3) days. In patients with sepsis we detected a significant decline in the average of IL-6 serum levels after 48 h of admission [7.50 (SD: 7.00–68.00) pg/mL vs. 68.00 [SD: 7.00–300.00] pg/mL (P = 0.000). Only 25% of patients with septic shock who presented high levels of IL-6 at the time of admission and at 48 h had a survival up to 15 days (P = 0.005).ConclusionWe found significant differences between the plasma levels of IL-6 during the first 48 h after admission to the ICU among patients with sepsis and septic shock. Patients with sepsis had a significant decline in IL-6 levels, whereas in patients who developed septic shock, levels of this cytokine remained high and have a lower survival compared to those who maintained low levels of IL-6.

scholarly journals The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients With Hypothyroidism

2019 ◽  
Vol 104 (12) ◽  
pp. 5915-5922
Author(s):  
Aditya S Shirali ◽  
James X Wu ◽  
Catherine Y Zhu ◽  
Alfonso Ocampo ◽  
Chi-Hong Tseng ◽  
...  
Keyword(s):  
Septic Shock ◽  
Test Performance ◽  
Serum Levels ◽  
Primary Hypothyroidism ◽  
Bacterial Sepsis ◽  
Thyroid C Cells ◽  
Failure Assessment ◽  
History Of ◽  
Sepsis And Septic Shock ◽  
Design And Methods

Abstract Context Serum levels of procalcitonin (PCT), a protein produced by the thyroid C cells under physiologic conditions, are high during sepsis. Objective To assess the test performance of serum PCT in predicting bacterial sepsis and septic shock in patients with hypothyroidism compared with those who have euthyroidism. Design and Methods This retrospective study evaluated patients with no history of thyroid dysfunction (euthyroid), primary hypothyroidism [medical hypothyroidism (MH)], and postsurgical hypothyroidism from total thyroidectomy (TT) identified from a prospectively maintained database who had PCT testing from 2005 to 2018. Quick Sequential Organ Failure Assessment score ≥ 2 or positive bacterial cultures identified bacterial sepsis, and a mean arterial pressure less than 65 mm Hg or a vasopressor requirement defined septic shock. Sensitivity and specificity of PCT for evaluation of bacterial sepsis and septic shock were measured. Results We identified 217 euthyroid patients, 197 patients with MH, and 84 patients with TT. Bacterial sepsis was found in 98 (45.2%), 92 (46.7%), and 36 (42.9%) of these patients, respectively (P > 0.05). Septic shock was identified in 13 (6.0%), 13 (6.6%), and 5 (6.0%) patients (P > 0.05), respectively. With use of a PCT cutoff of 0.5 µg/L for bacterial sepsis, the sensitivity was 59%, 61%, and 53% (P > 0.05) and specificity was 81%, 77%, and 81% (P > 0.05) for the diagnosis of bacterial sepsis in euthyroid, MH, and TT patients, respectively. With use of a PCT cutoff of 2.0 µg/L for septic shock, the sensitivity was 46%, 62%, and 63% (P > 0.05) and specificity was 86%, 82%, and 91% (P > 0.05) for the diagnosis of septic shock in these patients, respectively. Conclusions Despite the thyroidal origin of PCT, hypothyroidism did not affect the diagnostic performance of serum PCT levels in predicting bacterial sepsis or septic shock.

Interleukin-6 and procalcitonin in children with sepsis and septic shock

Cytokine ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 160-164 ◽  
Author(s):  
José R. Fioretto ◽  
Joelma G. Martin ◽  
Cilmery S. Kurokawa ◽  
Mário F. Carpi ◽  
Rossano C. Bonatto ◽  
...  
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Sepsis And Septic Shock

scholarly journals Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

2019 ◽  
Author(s):  
Juhyun Song ◽  
Dae Won Park ◽  
Sungwoo Moon ◽  
Han-Jin Cho ◽  
Jong Hak Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Controlled Study ◽  
Pentraxin 3 ◽  
Clinical Value ◽  
International Consensus ◽  
Sepsis And Septic Shock ◽  
Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

scholarly journals Assessment and Management of Hypoperfusion in Sepsis and Septic Shock

2021 ◽  
Author(s):  
Zohair Al Aseri
Keyword(s):  
Blood Pressure ◽  
Septic Shock ◽  
Fluid Resuscitation ◽  
Early Treatment ◽  
Daily Practice ◽  
Normal Blood ◽  
Organ Perfusion ◽  
Emergency Physicians ◽  
Normal Blood Pressure ◽  
Sepsis And Septic Shock

Diagnosis of organ hypoperfusion in patient with sepsis is not always straightforward which makes septic shock definition, diagnosis, and early treatment are major challenges that emergency physicians and intensivist must deal with in their daily practice. Normal blood pressure does not always mean good organ perfusion, which means patient might develop septic shock, yet they are not hypotensive. There are several indices that could be used in combination to diagnose and manage hypoperfusion in patients with septic shock. Fluid resuscitation and vasopressor administration along with infection sources control are the cornerstones in septic shock management. This chapter will cover indices that can be used to diagnose hypoperfusion, type and amount of fluid and vasopressor that can be used in resuscitating septic shock patients.

scholarly journals Circulating miR-147b as a diagnostic marker for patients with bacterial sepsis and septic shock

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261228
Author(s):  
Ngo Tat Trung ◽  
Tran Thi Lien ◽  
Vu Viet Sang ◽  
Nghiem Xuan Hoan ◽  
Nguyen Dang Manh ◽  
...  
Keyword(s):  
Septic Shock ◽  
Diagnostic Marker ◽  
Antimicrobial Treatment ◽  
Patient Stratification ◽  
Circulating Biomarkers ◽  
Bacterial Sepsis ◽  
Diagnostic Potential ◽  
Sepsis And Septic Shock ◽  
Plasma Mirnas ◽  
Subsequent Patient

Background Early diagnosis, precise antimicrobial treatment and subsequent patient stratification can improve sepsis outcomes. Circulating biomarkers such as plasma microRNAs (miRNAs) have proven to be surrogates for diagnosis, severity and case management of infections. The expression of four selected miRNAs (miR-146-3p, miR-147b, miR-155 and miR-223) was validated for their prognostic and diagnostic potential in a clinically defined cohort of patients with sepsis and septic shock. Methods The expression of plasma miRNAs was quantified by quantitative PCR (qPCR) in patients with bacterial sepsis (n = 78), in patients with septic shock (n = 52) and in patients with dengue haemorrhagic fever (DHF; n = 69) and in healthy controls (n = 82). Results The expression of studied miRNA was significantly increased in patients with bacterial sepsis and septic shock. The plasma miR-147b was able to differentiate bacterial sepsis from non-sepsis and septic shock (AUC = 0.77 and 0.8, respectively, p≤ 0.05), while the combination of plasma miR-147b and procalcitonin (PCT) predicted septic shock (AUC = 0.86, p≤ 0.05). Conclusions The plasma miR-147b may be an useful biomarker independently or in combination with PCT to support clinical diagnosis of sepsis and equally prognosis of patients with septic shock.

scholarly journals Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

2019 ◽  
Author(s):  
Juhyun Song ◽  
Dae Won Park ◽  
Sungwoo Moon ◽  
Han-Jin Cho ◽  
Jong Hak Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Controlled Study ◽  
Pentraxin 3 ◽  
Clinical Value ◽  
International Consensus ◽  
Sepsis And Septic Shock ◽  
Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

scholarly journals Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Juhyun Song ◽  
Dae Won Park ◽  
Sungwoo Moon ◽  
Han-Jin Cho ◽  
Jong Hak Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Controlled Study ◽  
Pentraxin 3 ◽  
Clinical Value ◽  
International Consensus ◽  
Sepsis And Septic Shock ◽  
Diagnostic And Prognostic Value

Abstract Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 h of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P <  0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71–0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P <  0.001). Conclusions The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

Sign in / Sign up

Export Citation Format

Share Document