scholarly journals PROSTATE CANCER: EVIDENCE OF GENETIC AND ENVIRONMENTAL FACTORS, PARTICULARLY REGARDING OXIDATIVE STRESS

2012 ◽  
Vol 3 (1) ◽  
pp. 43 ◽  
Author(s):  
Cecilia Anichini
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Environmental Factors ◽  
Genetic And Environmental Factors

scholarly journals Mechanisms and modifiers of methylmercury-induced neurotoxicity

2012 ◽  
Vol 1 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Stephanie J. B. Fretham ◽  
Samuel Caito ◽  
Ebany J. Martinez-Finley ◽  
Michael Aschner
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Environmental Factors ◽  
Genetic Polymorphisms ◽  
Experimental Studies ◽  
Mehg Exposure ◽  
Complete Understanding ◽  
Cellular Processes ◽  
Gene Environment ◽  
Genetic And Environmental Factors

Abstract The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided mechanistic insights into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss epigenetic modifications, genetic polymorphisms and gene–environment interactions capable of modifying MeHg neurotoxicity.

scholarly journals Etiology of Parkinson's Disease

2003 ◽  
Vol 30 (S1) ◽  
pp. S10-S18 ◽  
Author(s):  
Zhigao Huang ◽  
Raúl de la Fuente-Fernández ◽  
A. Jon Stoessl
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Environmental Factors ◽  
Neurodegenerative Disorders ◽  
Caffeine Intake ◽  
Genetic Mutations ◽  
Abnormal Protein ◽  
Relative Contribution ◽  
Genetic And Environmental Factors

There is growing recognition that Parkinson's disease (PD) is likely to arise from the combined effects of genetic predisposition as well as largely unidentified environmental factors. The relative contribution of each varies from one individual to another. Even in situations where more than one family member is affected, the predominant influence may be environmental. Although responsible for only a small minority of cases of PD, recently identified genetic mutations have provided tremendous insights into the basis for neurodegeneration and have led to growing recognition of the importance of abnormal protein handling in Parkinson's as well as other neurodegenerative disorders. Abnormal protein handling may increase susceptibility to oxidative stress; conversely, numerous other factors, including oxidative stress and impaired mitochondrial function can lead to impaired protein degradation. A limited number of environmental factors are known to be toxic to the substantia nigra; in contrast, some factors such as caffeine intake and cigarette smoking may protect against the development of PD, although the mechanisms are not established. We review the various genetic and environmental factors thought to be involved in PD, as well as the mechanisms that contribute to selective nigral cell death.

Links between genetic and environmental factors and prostate cancer risk

The Prostate ◽  
1999 ◽  
Vol 39 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Peter Ekman ◽  
Henrik Gr�nberg ◽  
Hideyasu Matsuyama ◽  
Merja Kivineva ◽  
Ulf S.R. Bergerheim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Environmental Factors ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Genetic And Environmental Factors

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

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