scholarly journals CORYNEBACTERIUM STRIATUM: EPIDEMIOLOGIA E SENSIBILITÀ AGLI ANTIBIOTICI DI UN PATOGENO EMERGENTE

2007 ◽  
Vol 22 (3) ◽  
Author(s):  
B. Pini ◽  
G. Brigante ◽  
G. Sokeng ◽  
S. Gualandris ◽  
F. Luzzaro ◽  
...  
Keyword(s):  
Corynebacterium Striatum

scholarly journals Infective Endocarditis Due to Corynebacterium Species: Clinical Features and Antibiotic Resistance

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Anna Bläckberg ◽  
Linn Falk ◽  
Karl Oldberg ◽  
Lars Olaison ◽  
Magnus Rasmussen
Keyword(s):  
Antibiotic Resistance ◽  
Infective Endocarditis ◽  
Prosthetic Valve Endocarditis ◽  
Penicillin G ◽  
Severe Condition ◽  
Ionization Time ◽  
Prosthetic Valves ◽  
Corynebacterium Species ◽  
Corynebacterium Striatum

Abstract Background Corynebacterium species are often dismissed as contaminants in blood cultures, but they can also cause infective endocarditis (IE), which is a severe condition. Antibiotic resistance of corynebacteria is increasing making treatment challenging. Reports on IE caused by Corynebacterium species are scarce and more knowledge is needed. Methods Cases of IE caused by Corynebacterium species were identified through the Swedish Registry of Infective Endocarditis. Isolates were collected for species redetermination by matrix-assisted laser desorption ionization-time of flight and for antibiotic susceptibility testing using Etests. Results Thirty episodes of IE due to Corynebacterium species were identified between 2008 and 2017. The median age of patients was 71 years (interquartile range, 60–76) and 77% were male. Corynebacterium striatum (n = 11) was the most common IE causing pathogen followed by Corynebacterium jeikeium (n = 5). Surgery was performed in 50% and in-hospital mortality rate was 13%. Patients with IE caused by Corynebacterium species were significantly more likely to have prosthetic valve endocarditis (70%), compared with patients with IE due to Staphylococcus aureus or non-beta-hemolytic streptococci (14% and 26%, respectively) (P < .0001). Vancomycin was active towards all Corynebacterium isolates, whereas resistance towards penicillin G was common. Conclusions Corynebacterium species cause IE, where prosthetic valves are mainly affected and surgery is often performed. Corynebacterium striatum is an important causative agent of IE within the genus. Antibiotic resistance of corynebacteria is relatively common but resistance towards vancomycin could not be detected in vitro.

scholarly journals Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020

2021 ◽  
Author(s):  
Giorgio Silva-Santana ◽  
Cecília Maria Ferreira Silva ◽  
Julianna Giordano Botelho Olivella ◽  
Igor Ferreira Silva ◽  
Laís Menegoi Oliveira Fernandes ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Nosocomial Outbreak ◽  
Corynebacterium Striatum ◽  
Invasive Infections

scholarly journals Genome sequence of a multidrug-resistant Corynebacterium striatum isolated from bloodstream infection from a nosocomial outbreak in Rio de Janeiro, Brazil

2018 ◽  
Vol 113 (9) ◽  
Author(s):  
Juliana Nunes Ramos ◽  
Izabel dos Santos Rodrigues ◽  
Paulo Victor Pereira Baio ◽  
João Flávio Carneiro Veras ◽  
Rommel Thiago Jucá Ramos ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Genome Sequence ◽  
Rio De Janeiro ◽  
Multidrug Resistant ◽  
Nosocomial Outbreak ◽  
Corynebacterium Striatum

scholarly journals Antimicrobial susceptibility pattern of Corynebacterium striatum.

1996 ◽  
Vol 40 (11) ◽  
pp. 2671-2672 ◽  
Author(s):  
L Martínez-Martínez ◽  
A Pascual ◽  
K Bernard ◽  
A I Suárez
Keyword(s):  
Antimicrobial Susceptibility ◽  
Antimicrobial Agents ◽  
Susceptibility Pattern ◽  
Beta Lactams ◽  
Antimicrobial Susceptibility Pattern ◽  
Mueller Hinton ◽  
Corynebacterium Striatum ◽  
Mueller Hinton Broth

The in vitro activities of 16 antimicrobial agents against 86 strains of Corynebacterium striatum were evaluated by microdilution using cation-adjusted Mueller-Hinton broth. MICs at which 90% of strains were inhibited were 0.06 microgram/ml for teicoplanin, 1 microgram/ml for vancomycin, 0.03 to 8 micrograms/ml for beta-lactams, 8 micrograms/ml for sparfloxacin, 16 micrograms/ml for ciprofloxacin, 16/304 micrograms/ml for co-trimoxazole (trimethoprim-sulfamethoxazole), 64 micrograms/ml for tetracycline, 128 micrograms/ml for gentamicin, and > 128 micrograms/ml for amikacin, erythromycin, and rifampin.

Exit-site Infections by Non-diphtheria Corynebacteria in Capd

2004 ◽  
Vol 24 (5) ◽  
pp. 454-459 ◽  
Author(s):  
Helmut Schiffl ◽  
Claudia Mücke ◽  
Susanne M. Lang
Keyword(s):  
Site Infection ◽  
Exit Site ◽  
Oral Cephalosporin ◽  
Exit Site Infection ◽  
Corynebacterium Species ◽  
Corynebacterium Striatum ◽  
Biochemical Identification ◽  
Stage Renal Disease ◽  
End Stage ◽  
Observation Period

Non-diphtheria corynebacteria species cause disease in risk populations such as immunocompromised patients and patients with indwelling medical devices. Despite reports of exit-site infection and peritonitis caused by non-diphtheria corynebacteria, these organisms are frequently dismissed as contaminants. During a 10-year observation period, we prospectively identified 8 cases of exit-site/tunnel infections caused by 2 different species of corynebacteria ( Corynebacterium striatum in 5 and C. jeikeium in 3 cases). Four patients experienced a second episode of exit-site infection 3 months (2 cases), 25 months, and 40 months, respectively, after termination of an oral cephalosporin therapy of 4 to 6 weeks’ duration. Non-diphtheria corynebacteria accounted for 9% of all exit-site infections during the study period. All catheter-related infections healed; no catheter had to be removed. The diagnosis of catheter-related non-diphtheria corynebacteria infection may be suspected when Gram stain shows gram-positive rods and with colony morphology and commercial biochemical identification systems. Susceptibility of non-diphtheria corynebacteria to antibiotics may vary, especially in C. jeikeium. Virtually all Corynebacterium species are sensitive to vancomycin. Empirical antibiotic therapy with vancomycin should be initiated while antibiotic susceptibility testing is being carried out. Oral cephalosporin may be an alternative treatment regimen for exit-site infections if sensitive. This study highlights the importance of non-diphtheria corynebacteria as emerging nosocomial pathogens in the population of end-stage renal disease patients on on continuous ambulatory peritoneal dialysis.

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