Efficacy of gluten-free diet in patients with rheumatoid arthritis

Recent research has increasingly shown that depending on the foods we eat, gut flora may be affected by an inflammatory or anti-inflammatory response, thus playing an important role in inflammatory autoimmune diseases, such as rheumatoid arthritis or gastroenterological disorders. Gluten seems to be a glycoprotein with a clinically relevant inflammatory effect. Several observational studies and anecdotal cases reported a correlation between gluten and various diseases, including autoimmune diseases, such as rheumatoid arthritis. This study aimed to evaluate whether gluten-free diet could be effective in controlling inflammation and ongoing rheumatoid arthritis symptoms. We report 4 cases of patients with long-standing rheumatoid arthritis with no response to several conventional and biotechnological drugs, treated with a gluten-free diet concurrently with the drug therapy. Our patients presented different degrees of response to the diet, in terms of disease remission and improvement of symptoms. Our cases confirm that a gluten-free diet may improve symptoms of rheumatoid arthritis, even in patients resistant to conventional drug therapies.

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Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies

Gastroenterology ◽

10.1053/j.gastro.2017.04.009 ◽

2017 ◽

Vol 153 (2) ◽

pp. 395-409.e3 ◽

Cited By ~ 37

Author(s):

María Inés Pinto-Sánchez ◽

Natalia Causada-Calo ◽

Premysl Bercik ◽

Alexander C. Ford ◽

Joseph A. Murray ◽

...

Keyword(s):

Systematic Review ◽

Celiac Disease ◽

Observational Studies ◽

Meta Analysis ◽

Gluten Free Diet ◽

Gluten Free

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Clinical Characteristics and Management of 50 Patients with Anti-GAD Ataxia: Gluten-Free Diet Has a Major Impact

The Cerebellum ◽

10.1007/s12311-020-01203-w ◽

2020 ◽

Author(s):

M. Hadjivassiliou ◽

P. G. Sarrigiannis ◽

P. D. Shanmugarajah ◽

D. S. Sanders ◽

R. A. Grünewald ◽

...

Keyword(s):

Autoimmune Diseases ◽

Clinical Characteristics ◽

Age At Onset ◽

Gluten Free Diet ◽

Gluten Sensitivity ◽

Gluten Free ◽

Progressive Ataxia ◽

Progressive Cerebellar Ataxia ◽

Limb Ataxia ◽

History Of

Abstract The objective of this study is to report the clinical characteristics and treatment of patients with progressive cerebellar ataxia associated with anti-GAD antibodies. We performed a retrospective review of all patients with anti-GAD ataxia managed at the Sheffield Ataxia Centre over the last 25 years. We identified 50 patients (62% females) with anti-GAD ataxia. The prevalence was 2.5% amongst 2000 patients with progressive ataxia of various causes. Mean age at onset was 55 and mean duration 8 years. Gaze-evoked nystagmus was present in 26%, cerebellar dysarthria in 26%, limb ataxia in 44% and gait ataxia in 100%. Nine patients (18%) had severe, 12 (24%) moderate and 29 (58%) mild ataxia. Ninety percent of patients had a history of additional autoimmune diseases. Family history of autoimmune diseases was seen in 52%. Baseline MR spectroscopy of the vermis was abnormal at presentation in 72%. Thirty-five patients (70%) had serological evidence of gluten sensitivity. All 35 went on gluten-free diet (GFD). Eighteen (51%) improved, 13 (37%) stabilised, 3 have started the GFD too recently to draw conclusions and one deteriorated. Mycophenolate was used in 16 patients, 7 (44%) improved, 2 stabilised, 6 have started the medication too recently to draw conclusions and one did not tolerate the drug. There is considerable overlap between anti-GAD ataxia and gluten ataxia. For those patients with both, strict GFD alone can be an effective treatment. Patients with anti-GAD ataxia and no gluten sensitivity respond well to immunosuppression.

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PRELIMINARY REPORT OF THE TREATMENT OF RHEUMATOID ARTHRITIS WITH HIGH PROTEIN GLUTEN‐FREE DIET AND SUPPLEMENTS

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1964.tb115621.x ◽

1964 ◽

Vol 2 (5) ◽

pp. 169-172 ◽

Cited By ~ 8

Author(s):

R. Shatin

Keyword(s):

Rheumatoid Arthritis ◽

Preliminary Report ◽

High Protein ◽

Gluten Free Diet ◽

Gluten Free

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Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach

Journal of Clinical Medicine ◽

10.3390/jcm8030347 ◽

2019 ◽

Vol 8 (3) ◽

pp. 347 ◽

Cited By ~ 13

Author(s):

Kalthoum Tizaoui ◽

Seon Kim ◽

Gwang Jeong ◽

Andreas Kronbichler ◽

Kwang Lee ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Diabetes Mellitus ◽

Juvenile Idiopathic Arthritis ◽

Autoimmune Diseases ◽

Observational Studies ◽

Meta Analysis ◽

P Value ◽

Bayesian Approaches ◽

Anca Associated Vasculitis

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. We conducted a PubMed search to identify relevant publications and extracted the respective results, published until 30 November 2018. In observational studies, the associations of 1858 C/T genetic variant were noteworthy for 12 autoimmune or autoimmunity-related diseases (rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, juvenile idiopathic arthritis, Crohn’s disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, vitiligo, Graves’ disease, myasthenia gravis, Addison’s disease, giant cell arteritis, and endometriosis). In contrast, we could not confirm the noteworthiness for eight diseases (systemic sclerosis, psoriasis, Behçet’s disease, autoimmune thyroid disease, alopecia areata, Sjögren’s syndrome, inflammatory bowel disease, and ankylosing spondylitis). From the meta-analysis of genome-wide association studies (GWAS) with a p-value < 5 × 10−8, findings verified noteworthiness for all autoimmune diseases (psoriatic arthritis, myasthenia gravis, juvenile idiopathic arthritis and rheumatoid arthritis). The results from meta-analysis of GWAS showing a p-value ranging between 0.05 and 5 × 10−8 were noteworthy under both Bayesian approaches (ANCA-associated vasculitis, type 1 diabetes mellitus, giant cell arteritis and juvenile idiopathic arthritis). Re-analysis of observational studies and GWAS by Bayesian approaches revealed the noteworthiness of all significant associations observed by GWAS, but noteworthiness could not be confirmed for all associations found in observational studies.

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Incidence of Autoimmune Diseases in Celiac Disease: Protective Effect of the Gluten-Free Diet

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/mpg.0b013e31819770fe ◽

2009 ◽

Vol 48 (5) ◽

pp. 645-646 ◽

Cited By ~ 4

Author(s):

Richard L Mones

Keyword(s):

Celiac Disease ◽

Autoimmune Diseases ◽

Protective Effect ◽

Gluten Free Diet ◽

Gluten Free

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Celiac disease in a patient with type 1 diabetes

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-169-9-107-112 ◽

2020 ◽

pp. 107-112

Author(s):

M. A. Livzan ◽

O. V. Gaus ◽

M. V. Kolbina ◽

F. Zh. Karasaeva ◽

O. A. Ratnikova

Keyword(s):

Type 1 Diabetes ◽

Celiac Disease ◽

Autoimmune Diseases ◽

Clinical Case ◽

Rapid Development ◽

Epidemiological Studies ◽

Gluten Free Diet ◽

Gluten Free ◽

Genetic And Environmental Factors

The interaction of genetic and environmental factors leads to development of autoimmune diseases. Autoimmune diseases have common pathogenetic mechanisms and are combined often. in recent years Epidemiological studies have shown a significant increase in the prevalence of celiac disease in patients with type 1 diabetes mellitus (T1DM) in recent years. Comorbid pathology is a heavy clinical case to determine the treatment of patients. The association of celiac disease and T1DM leads to enhanced immune response and rapid development and progression of complications. A gluten-free diet is only treatment for celiac disease. Gluten-free diet complicates glycemic control. This article presents our clinical case of a patient with combination of celiac disease and T1DM.

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Incidence of Autoimmune Diseases in Celiac Disease: Protective Effect of the Gluten-Free Diet

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2007.12.022 ◽

2008 ◽

Vol 6 (7) ◽

pp. 753-758 ◽

Cited By ~ 184

Author(s):

J COSNES ◽

C CELLIER ◽

S VIOLA ◽

J COLOMBEL ◽

L MICHAUD ◽

...

Keyword(s):

Celiac Disease ◽

Autoimmune Diseases ◽

Protective Effect ◽

Gluten Free Diet ◽

Gluten Free

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Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-021-00597-4 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Zhiyu Lu ◽

Ni Zeng ◽

Yuxin Cheng ◽

Yihe Chen ◽

Yueyue Li ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Ulcerative Colitis ◽

Atopic Dermatitis ◽

Celiac Disease ◽

Autoimmune Diseases ◽

Lupus Erythematosus ◽

Observational Studies ◽

Meta Analysis ◽

Systematic Lupus Erythematosus

Abstract Background Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermatitis with autoimmune disorders. However, there is no meta-analysis of the prevalence or incidence of autoimmune diseases in atopic dermatitis. Therefore, considering the potential clinical implications of these associations, we aimed to assess the risk of autoimmune diseases in patients with atopic dermatitis using this method. Methods PubMed, Embase, and Web of Science were searched from inception to October, 2020. Observational studies which provided estimate effects with 95% CI or raw data were included. The quality of selected studies was evaluated using the Newcastle–Ottawa Scale. Odds ratio and relative risks were pooled using a random effects model and expressed with 95% confidence intervals. Results Fourteen observational studies were included in this systematic review and meta-analysis. The random-effects meta-analysis of case–control and cross-sectional studies showed a significant association of atopic dermatitis with mutiple autoimmune diseases, including alopecia areata, celiac disease, Crohn’s disease, rheumatoid arthritis, systematic lupus erythematosus, ulcerative colitis and vitiligo. Furthermore, pooling of the results of cohort studies showed that patients with atopic dermatitis were more likely to develop these autoimmune diseases. Conclusion Our meta-analysis showed that patients with atopic dermatitis were at higher risk of multiple autoimmune diseases including alopecia areata, celiac disease, Crohn’s disease, rheumatoid arthritis, systematic lupus erythematosus, ulcerative colitis and vitiligo. It is important for early detection of the affected group so that timely management can be initiated. Dermatologists and allergists should be aware of the autoimmune diseases in patients with atopic dermatitis and develop interventions if necessary. Also, limited by the present research, we still require more large-scale studies to further establish the association between atopic dermatitis and autoimmune diseases.

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