scholarly journals Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach

2019 ◽  
Vol 8 (3) ◽  
pp. 347 ◽  
Author(s):  
Kalthoum Tizaoui ◽  
Seon Kim ◽  
Gwang Jeong ◽  
Andreas Kronbichler ◽  
Kwang Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Juvenile Idiopathic Arthritis ◽  
Autoimmune Diseases ◽  
Observational Studies ◽  
Meta Analysis ◽  
P Value ◽  
Bayesian Approaches ◽  
Anca Associated Vasculitis

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. We conducted a PubMed search to identify relevant publications and extracted the respective results, published until 30 November 2018. In observational studies, the associations of 1858 C/T genetic variant were noteworthy for 12 autoimmune or autoimmunity-related diseases (rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, juvenile idiopathic arthritis, Crohn’s disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, vitiligo, Graves’ disease, myasthenia gravis, Addison’s disease, giant cell arteritis, and endometriosis). In contrast, we could not confirm the noteworthiness for eight diseases (systemic sclerosis, psoriasis, Behçet’s disease, autoimmune thyroid disease, alopecia areata, Sjögren’s syndrome, inflammatory bowel disease, and ankylosing spondylitis). From the meta-analysis of genome-wide association studies (GWAS) with a p-value < 5 × 10−8, findings verified noteworthiness for all autoimmune diseases (psoriatic arthritis, myasthenia gravis, juvenile idiopathic arthritis and rheumatoid arthritis). The results from meta-analysis of GWAS showing a p-value ranging between 0.05 and 5 × 10−8 were noteworthy under both Bayesian approaches (ANCA-associated vasculitis, type 1 diabetes mellitus, giant cell arteritis and juvenile idiopathic arthritis). Re-analysis of observational studies and GWAS by Bayesian approaches revealed the noteworthiness of all significant associations observed by GWAS, but noteworthiness could not be confirmed for all associations found in observational studies.

scholarly journals AB0161 THE IMPACT OF BIOLOGICAL AGENTS ON CARDIOVASCULAR RISK FACTORS OF PATIENTS DIAGNOSED WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1107.2-1108
Author(s):  
G. Papamichail ◽  
T. Markatseli ◽  
A. Georgiadis ◽  
V. Xydis ◽  
C. Milionis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Observational Studies ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Biological Agents ◽  
P Value ◽  
One Year ◽  
Early Atherosclerosis

Background:The risk of cardiovascular disease in patients with rheumatoid arthritis (RA) is 1.5-2 fold higher than in people of the same age and sex of the general population.1,2,3 This marked risk is attributed to the systemic chronic inflammation which is characteristic of the disease.Objectives:The aim of this study is to evaluate cardiovascular risk factors and early atherosclerosis in rheumatoid arthritis patients, treated with biological agents.Methods:This is a prospective, observational study. Thirty-five patients treated with synthetic DMARDs with no previous history of a cardiovascular event included. We compared total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TGs), Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB) and Lipoprotein A (LpA), the titer of autoantibodies against oxidised LDL(anti-oxLDL), systolic blood pressure, inflammatory markes as C-reactive protein (CRP) and erythrocytes sedimentation rate (ESR) between baseline and after 6 months of biological agents initiation. An ultrasonographic measurement of intima-media thickness (IMT) of carotids was also performed by an experienced sonographer at baseline and after one-year follow-up.Results:As regards the demographic characteristics of patients, the mean (SD) age was 54(14) years, disease duration 4,3(1.4) years, 22.9% were smokers and 68,6% were women. Anti-TNF was administered in 71,4% of patients while the rest non anti-TNF was given as treatment. Six months after treatment initiation, patients presented with a significant increase in mean (SD) HDL[69(19)vs58(15)] and ApoA1[177(34)vs162(31)] levels (p value <0,001) with a simultaneous significant reduction of mean (SD) systolic blood pressure [128(12)vs136(14)] and the titer of anti-oxLDL[0,132(0,042)vs0,190(0,056)]. ΙΜΤ was also reduced after one-year reassessment [0,8(0,3) mm vs 0,9(0,3)mm, (p value <0,001 for all comparisons)].Conclusion:Biological agents administration was accompanied by an improved lipid profile in a six-month period and a significant reduction of IMT, confirming that RA patients are prone to early atherosclerosis and probably biological agents initiation correlates strongly with cardiovascular risk reduction.References:[1]Avina-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis and rheumatism. 2008 Dec 15;59(12):1690–1697.[2]Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Annals of the rheumatic diseases. 2012 Sep;71(9):1524–1529.[3]Solomon DH, Karlson EW, Rimm EB, Cannuscio CC, Mandl LA, Manson JE, et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation. 2003 Mar 11;107(9):1303–1307.Disclosure of Interests:None declared

scholarly journals Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies

Diabetologia ◽  
2015 ◽  
Vol 59 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Eileen Morgan ◽  
Sophia R. Halliday ◽  
Gemma R. Campbell ◽  
Chris R. Cardwell ◽  
Chris C. Patterson
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Observational Studies ◽  
Meta Analysis ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

scholarly journals Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Zhiyu Lu ◽  
Ni Zeng ◽  
Yuxin Cheng ◽  
Yihe Chen ◽  
Yueyue Li ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Ulcerative Colitis ◽  
Atopic Dermatitis ◽  
Celiac Disease ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Observational Studies ◽  
Meta Analysis ◽  
Systematic Lupus Erythematosus

Abstract Background Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermatitis with autoimmune disorders. However, there is no meta-analysis of the prevalence or incidence of autoimmune diseases in atopic dermatitis. Therefore, considering the potential clinical implications of these associations, we aimed to assess the risk of autoimmune diseases in patients with atopic dermatitis using this method. Methods PubMed, Embase, and Web of Science were searched from inception to October, 2020. Observational studies which provided estimate effects with 95% CI or raw data were included. The quality of selected studies was evaluated using the Newcastle–Ottawa Scale. Odds ratio and relative risks were pooled using a random effects model and expressed with 95% confidence intervals. Results Fourteen observational studies were included in this systematic review and meta-analysis. The random-effects meta-analysis of case–control and cross-sectional studies showed a significant association of atopic dermatitis with mutiple autoimmune diseases, including alopecia areata, celiac disease, Crohn’s disease, rheumatoid arthritis, systematic lupus erythematosus, ulcerative colitis and vitiligo. Furthermore, pooling of the results of cohort studies showed that patients with atopic dermatitis were more likely to develop these autoimmune diseases. Conclusion Our meta-analysis showed that patients with atopic dermatitis were at higher risk of multiple autoimmune diseases including alopecia areata, celiac disease, Crohn’s disease, rheumatoid arthritis, systematic lupus erythematosus, ulcerative colitis and vitiligo. It is important for early detection of the affected group so that timely management can be initiated. Dermatologists and allergists should be aware of the autoimmune diseases in patients with atopic dermatitis and develop interventions if necessary. Also, limited by the present research, we still require more large-scale studies to further establish the association between atopic dermatitis and autoimmune diseases.

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