Clinical Implication of Plasma Uric Acid Level

2009 ◽  
Vol 30 (9) ◽  
pp. 670 ◽  
Author(s):  
Young Tae Shin ◽  
Kyoung Kon Kim ◽  
In Cheol Hwang
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Clinical Implication ◽  
Acid Level ◽  
Plasma Uric Acid

Blood Uric Acid Level and IQ: A Study in Twin Families

1984 ◽  
Vol 33 (2) ◽  
pp. 237-242 ◽  
Author(s):  
E. Inouye ◽  
K.S. Park ◽  
A. Asaka
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Quantitative Traits ◽  
Acid Level ◽  
Genetic Basis ◽  
Plasma Uric Acid ◽  
Blood Uric Acid ◽  
Twin Children ◽  
Twin Families ◽  
Familial Environment

AbstractApplying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (ρ) was approximately 0.1, and variance due to common familial environment (VEC/Vp) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, ρ being 0.34 and 0.04, and VEC/Vp being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p < 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.

scholarly journals A higher baseline plasma uric acid level is an independent predictor of arterial stiffness

Medicine ◽  
2017 ◽  
Vol 96 (6) ◽  
pp. e5957 ◽  
Author(s):  
Xiao-Han Ding ◽  
Xiaona Wang ◽  
Ruihua Cao ◽  
Xu Yang ◽  
Wenkai Xiao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Arterial Stiffness ◽  
Uric Acid Level ◽  
Acid Level ◽  
Independent Predictor ◽  
Plasma Uric Acid

Low plasma uric acid level in Parkinson's disease

2007 ◽  
Vol 22 (8) ◽  
pp. 1133-1137 ◽  
Author(s):  
Tua Annanmaki ◽  
Antti Muuronen ◽  
Kari Murros
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Plasma Uric Acid

scholarly journals Plasma Uric Acid Level and Risk for Incident Hypertension Among Men

2006 ◽  
Vol 18 (1) ◽  
pp. 287-292 ◽  
Author(s):  
John P. Forman ◽  
Hyon Choi ◽  
Gary C. Curhan
Keyword(s):  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Incident Hypertension ◽  
Plasma Uric Acid

PLASMA URIC ACID LEVEL AND ITS ASSOCIATION WITH DIABETES MELLITUS AND SOME BIOLOGIC PARAMETERS IN A BIRACIAL POPULATION OF FIJI

1988 ◽  
Vol 127 (2) ◽  
pp. 321-336 ◽  
Author(s):  
JAAKKO TUOMILEHTO ◽  
PAUL ZIMMET ◽  
EVA WOLF ◽  
RICHARD TAYLOR ◽  
PARSHU RAM ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Plasma Uric Acid

scholarly journals Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Jingjing Zhou ◽  
Yuqing Chen ◽  
Ying Liu ◽  
Sufang Shi ◽  
Xueying Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Iga Nephropathy ◽  
Uric Acid Level ◽  
Acid Level ◽  
Early Stage ◽  
Plasma Uric Acid

scholarly journals Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Chihiro Moriya ◽  
Hiroaki Satoh
Keyword(s):  
Adipose Tissue ◽  
Uric Acid ◽  
Uric Acid Level ◽  
Wistar Rats ◽  
Acid Level ◽  
Xanthine Dehydrogenase ◽  
Epididymal Adipose Tissue ◽  
Chow Diet ◽  
Plasma Uric Acid ◽  
Male Wistar Rats

We investigated the effects of teneligliptin on uric acid metabolism in male Wistar rats and 3T3-L1 adipocytes. The rats were fed with a normal chow diet (NCD) or a 60% high-fat diet (HFD) with or without teneligliptin for 4 weeks. The plasma uric acid level was not significantly different between the control and teneligliptin groups under the NCD condition. However, the plasma uric acid level was significantly decreased in the HFD-fed teneligliptin treated rats compared to the HFD-fed control rats. The expression levels of xanthine dehydrogenase (Xdh) mRNA in liver and epididymal adipose tissue of NCD-fed rats were not altered by teneligliptin treatment. On the other hand,Xdhexpression was reduced significantly in the epididymal adipose tissue of the HFD-fed teneligliptin treated rats compared with that of HFD-fed control rats, whereasXdhexpression in liver did not change significantly in either group. Furthermore, teneligliptin significantly decreasedXdhexpression in 3T3-L1 adipocytes. DPP-4 treatment significantly increasedXdhexpression in 3T3-L1 adipocytes. With DPP-4 pretreatment, teneligliptin significantly decreasedXdhmRNA expression compared to the DPP-4-treated 3T3-L1 adipocytes. In conclusion, our studies suggest that teneligliptin reduces uric acid levels by suppressingXdhexpression in epididymal adipose tissue of obese subjects.

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