Blood Uric Acid Level and IQ: A Study in Twin Families

1984 ◽  
Vol 33 (2) ◽  
pp. 237-242 ◽  
Author(s):  
E. Inouye ◽  
K.S. Park ◽  
A. Asaka

AbstractApplying newly devised model, heritability (VA/VP) of plasma uric acid level, corrected for age and sex and standardized, was estimated at 0.8 in families consisting of twin parents, spouses and children. Correlation between spouses due to common genotype (ρ) was approximately 0.1, and variance due to common familial environment (VEC/Vp) was -0.3. Analysis of families of selected twin children and their parents resulted in two estimates of heritability: approximately 0.7 and 0.3, ρ being 0.34 and 0.04, and VEC/Vp being 0.04 and 0.34, respectively. Regression of IQ (y) on corrected and standardized plasma uric acid level (x) in the twin children was y = 5.56x + 123, correlation being 0.334 (p < 0.025). The result indicates a genetic basis of blood uric acid level, which may have resulted from polymorphisms in purine metabolism pathway, end product of which is uric acid in man. The significant correlation between plasma uric acid level and IQ suggests a contribution of partly common gene loci to the two quantitative traits.

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A177.1-A177
Author(s):  
Zhang Quan-Yu ◽  
Han yaling

2009 ◽  
Vol 30 (9) ◽  
pp. 670 ◽  
Author(s):  
Young Tae Shin ◽  
Kyoung Kon Kim ◽  
In Cheol Hwang

Medicine ◽  
2017 ◽  
Vol 96 (6) ◽  
pp. e5957 ◽  
Author(s):  
Xiao-Han Ding ◽  
Xiaona Wang ◽  
Ruihua Cao ◽  
Xu Yang ◽  
Wenkai Xiao ◽  
...  

2007 ◽  
Vol 22 (8) ◽  
pp. 1133-1137 ◽  
Author(s):  
Tua Annanmaki ◽  
Antti Muuronen ◽  
Kari Murros

2006 ◽  
Vol 18 (1) ◽  
pp. 287-292 ◽  
Author(s):  
John P. Forman ◽  
Hyon Choi ◽  
Gary C. Curhan

1990 ◽  
Vol 39 (1) ◽  
pp. 117-122 ◽  
Author(s):  
S. Ooki ◽  
K. Yamada ◽  
A. Asaka

AbstractThe present study deals with the relationship between blood uric acid level and human behavior. Subjects were 37 MZ and 7 DZ twins aged from 18 to 45 years. In males, blood uric acid level increased with age, while it decreased with age in females. Blood uric acid level was corrected and standardized using regression lines separately for males and females. The distribution of standardized uric acid level corresponded well with the theoretical curve of normal distribution. The intraclass correlation coefficient for standardized uric acid level was r = 0.370 (P < 0.05) for the 37 MZ twins, but not significant for the 7 DZ twins. These findings suggest that blood uric acid level is genetically controlled. By the analysis of 12 personality traits in YG (Yatabe-Guilford) character test, it was revealed that “General activity” was more controlled by genetically than environmentally. In the evaluation of the correlation between standardized uric acid level and the YG 12 personality traits, significant correlation was observed in “Lack of agreeableness” and “Rhathymia”. Since these two personality traits include the factor of “activity”, it is concluded that the plasma uric acid level and activity in a broader sense are under genetic control. This conclusion is consistent with the generally accepted view that persons with high uric acid level are more active and energetic than those with low level.


2015 ◽  
Vol 1 (2) ◽  
pp. 62-68
Author(s):  
Arif Rakhman ◽  
Iwan Purnawan ◽  
Arikh Ratna Purwadi

ABSTRAK Pendahuluan: Asam urat adalah produk akhir dari hasil metabolisme purin. Jumlah asam urat dalam darah dipengaruhi oleh makanan tinggi purin dan atau terganggunya pengeluaran asam urat melalui ginjal. Akupresur merupakan salah satu intervensi keperawatan dengan memberikan tekanan pada titik tertentu di permukaan tubuh menggunakan jari. Sudah banyak penelitian mengenai efektivitas terapi akupresur, namun belum ada yang meneliti efek terapi akupresur terhadap asam urat darah. Tujuan: Penelitian ini bertujuan untuk mengetahui efek terapi akupresur terhadap kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Metode: Penelitian ini merupakan penelitian pre experiment dengan pendekatan pre test-post test without control design. Pengambilan sampel menggunakan teknik total sampling. Besarnya sampel adalah 11 responden yang memenuhi kriteria inklusi dan eksklusi. Analisis data menggunakan uji statistik paired t test. Hasil: Rata-rata kadar asam urat darah sebelum dilakukan terapi akupresur adalah 5,99 mg/dl dan rata-rata kadar asam urat setelah dilakukan terapi akupresur adalah 4,04 mg/dl. Hasil uji paired t test didapatkan hasil t hitung = 2,441 (t hitung > dari t tabel) dan nilai p = 0,035 (p value<α = 0,05). Diskusi: Penurunan ini disebabkan adanya perbaikan fungsi ginjal dalam mensekresi asam urat dan penurunan produksi purin dari glikolisis otot yang terjadi akibat stres. Terdapat pengaruh yang signifikan terapi akupresur terhadap kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Terapi akupresur dapat menurunkan kadar asam urat darah pada lansia di Panti Wreda Catur Nugraha Kabupaten Banyumas. Kata Kunci: Akupresur, Asam urat, Lansia   ABSTRACT Introduction: Uric acid is the last product of purin metabolism. The amount of uric acid in blood influenced by food high purines and or impairement of uric acid excretion in kidney. Acupressure is one of nursing intervention by giving a pressure on specific point. There was many research about acupressure efectivity, but none did research about the effect of acupressure therapy on blood uric acid level. Objective: This study aimed to find out the effect of acupressure therapy on blood uric acid level towads elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas. Method: This study used pre experiment design with pre test- post test without control approach design and total sampling technique. The amount of sample was 11 respondent which had fulfill the inclution and exclution criteria. Data analysis used by statistical paired t test. Result: The average of uric acid level before accupressure therapy was 5.99 mg/dl and uric acid level after acupressure therapy was 4.04 mg/dl. The result of paired t test was obtained t= 2.441 (obtained t > table t) and value of p=0.035 (p<α=0,05). Discussion: The decrease of average blood uric acid level occured by kidney improvement in uric acid secretion and reduction of purin from muscle glicolisis as a consequence of stress. There was a significant effect of acupressure therapy on blood uric acid level in elderly at Panti Werdha Catur Nugraha Kabupaten Banyumas. Acupressure therapy could decrease blood uric acid level on elderly at Panti Wreda Catur Nugraha Kabupaten Banyumas. Keywords: Acupressure, Elderly, Uric AcidFull printable version: PDF


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