Correlation Between Different Levels of Placebo Response Rate and Clinical Trial Outcome in Major Depressive Disorder

2012 ◽  
Vol 73 (10) ◽  
pp. 1300-1306 ◽  
Author(s):  
Nadia Iovieno ◽  
George I. Papakostas
Keyword(s):  
Clinical Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Response Rate ◽  
Placebo Response ◽  
Major Depressive ◽  
Placebo Response Rate ◽  
Trial Outcome ◽  
Clinical Trial Outcome ◽  
Different Levels

Relationship between placebo response rate and clinical trial outcome in bipolar depression

2016 ◽  
Vol 74 ◽  
pp. 38-44 ◽  
Author(s):  
Nadia Iovieno ◽  
Andrew A. Nierenberg ◽  
Susannah R. Parkin ◽  
Daniel Ju Hyung Kim ◽  
Rosemary S.W. Walker ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Response Rate ◽  
Bipolar Depression ◽  
Placebo Response ◽  
Placebo Response Rate ◽  
Trial Outcome ◽  
Clinical Trial Outcome

scholarly journals Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Arash Mohagheghi ◽  
Asghar Arfaie ◽  
Shahrokh Amiri ◽  
Masoud Nouri ◽  
Salman Abdi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Visual Memory ◽  
Memory Deficit ◽  
Control Group ◽  
Major Depressive ◽  
Double Blind ◽  
The Impact

Introduction and Objective. Despite the effectiveness of electroconvulsive therapy (ECT) in treating major depressive disorder (MDD), its cognitive side effects make it less popular. This study investigated the impact of liothyronine on ECT-induced memory deficit in patients with MDD.Methodology. This is a double-blind clinical trial, in which 60 patients with MDD who were referred for ECT were selected. The diagnosis was based on the criteria of DSM-IV-TR. Patients were divided randomly into two groups to receive either liothyronine (50 mcg every morning) or placebo. After the assessment with Wechsler Memory Scale-Revised (WMS-R) before first session of ECT, posttests were repeated again, two months after the completion of ECT.Findings. By controlling the pretest scores, the mean scores of the experimental group were higher than the control group in delayed recall, verbal memory, visual memory, general memory, and attention/concentration scales (P<0.05).Conclusion. Liothyronine may prevent ECT-induced memory impairment in patients with MDD. This study has been registered in IRCT underIRCT201401122660N2.

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