The Impact of Treatment-Resistant Depression on Health Care Utilization and Costs

2002 ◽  
Vol 63 (11) ◽  
pp. 963-971 ◽  
Author(s):  
William H. Crown ◽  
Stan Finkelstein ◽  
Ernst R. Berndt ◽  
Davina Ling ◽  
Amy W. Poret ◽  
...  



2001 ◽  
Vol 4 (2) ◽  
pp. 146
Author(s):  
WH Crown ◽  
DCY Ling ◽  
SN Finkelstein ◽  
ER Berndt ◽  
AS White


2011 ◽  
Vol 24 (6) ◽  
pp. 520-533 ◽  
Author(s):  
Monica Mathys ◽  
Brian G. Mitchell

Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline. Untreated depressive symptoms lead to impaired social and occupational function, decline of physical health, suicidal thoughts, and increased health care utilization. Clinicians recognize there is an urgent need to find an efficacious treatment, but it becomes more difficult to decide on an appropriate therapy once a patient has failed 2 to 3 trials of antidepressants. An evidence-based review was performed to assess the efficacy and safety of several different antidepressant strategies to help the clinician decide which may be beneficial for specific patients.



Pharmacy ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 118
Author(s):  
Linda Xing Yu Liu ◽  
Marina Golts ◽  
Virginia Fernandes

The impact of depression is well described in the literature, and it is most prominent in patients who have trialed multiple treatments. Treatment-resistant depression (TRD) is particularly debilitating, and it is associated with significant morbidity and mortality. Despite this, there seems to be therapeutic inertia in adopting novel therapies in current practice. Ketamine is an N-methyl-D-aspartate receptor antagonist and anesthetic agent which has recently been shown to be effective in the management of TRD when administered intravenously or intranasally. The treatments, however, are not easily accessible due to restrictions in prescribing and dispensing, high costs, and the slow uptake of evidence-based practice involving ketamine within the Canadian healthcare system. Given the limited treatment options for TRD, novel approaches should be considered and adopted into practice, and facilitated by a multi-disciplinary approach. Pharmacists play a critical role in ensuring access to quality care. This includes dissemination of evidence supporting pharmacological treatments and facilitating translation into current practice. Pharmacists are uniquely positioned to collaborate with prescribers and assess novel treatment options, such as ketamine, address modifiable barriers to treatment, and triage access to medications during transitions of care. Extending the reach of these novel psychiatric treatments in both tertiary and primary care settings creates an emerging role for pharmacists in the collaborative effort to better manage treatment-resistant depression.



2011 ◽  
Vol 40 (4) ◽  
pp. 282-296 ◽  
Author(s):  
Nancy F. Bandstra ◽  
William B. Crist ◽  
Anne Napier-Phillips ◽  
Gordon Flowerdew


2018 ◽  
Vol 33 (8) ◽  
pp. 920-927 ◽  
Author(s):  
Hinda Ruton ◽  
Angele Musabyimana ◽  
Erick Gaju ◽  
Atakilt Berhe ◽  
Karen A Grépin ◽  
...  


2010 ◽  
Vol 13 (3) ◽  
pp. A198
Author(s):  
X Song ◽  
R Shenolikar ◽  
LA Costa ◽  
J Anderson ◽  
BC Chu


2016 ◽  
Vol 4 (2) ◽  
pp. 64-71 ◽  
Author(s):  
Patrick Arthur Twohig ◽  
Vaughn Huckfeldt

A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist. Despite the demonstrated short-term benefits of using intravenous (IV) ketamine, side effects and the difficulty in administering ketamine outside the health-care setting has raised interest in alternative dosage forms. Research articles evaluating oral or intranasal (IN) ketamine were retrieved from the PubMed database. Patients who received oral or IN ketamine experienced a similar reduction in depressive symptoms within 24 hours of treatment and fewer side effects compared to patients who received IV ketamine. Novel administration forms of ketamine provide an opportunity for patients with TRD to achieve remission with fewer adverse side effects. Future studies should continue to evaluate these administration strategies in the hope of promoting ketamine’s use outside health-care settings and for longer time periods.



2021 ◽  
Author(s):  
Marika Cabral ◽  
Colleen Carey ◽  
Sarah Miller


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