scholarly journals Effect of 2-hydroxy-4-methoxy benzoic acid isolated from Hemidesmus indicus on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-induced diabetic rats

2012 ◽  
Vol 74 (5) ◽  
pp. 474 ◽  
Author(s):  
M Gayathri ◽  
K Kannabiran
Keyword(s):  
Benzoic Acid ◽  
Erythrocyte Membrane ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Hemidesmus Indicus ◽  
Membrane Bound ◽  
Membrane Bound Enzymes

scholarly journals Taurine supplementation restores antioxidant status and hepatic membrane-bound enzymes in streptozotocin-induced diabetic rats

Biomedicine ◽  
2020 ◽  
Vol 39 (2) ◽  
pp. 263-267
Author(s):  
Baskaran Krishnan ◽  
Karunanithi Santha ◽  
Sivakamasundari Inmozhi ◽  
Sethupathy Subramanian ◽  
Kanumaru Balu Mahendran
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Chow Diet ◽  
Taurine Supplementation ◽  
Chronic Hyperglycemia ◽  
Group I ◽  
Membrane Bound ◽  
Membrane Bound Enzymes

Introduction and Aim: Chronic hyperglycemia in diabetes causes cellular damage through increased lipid peroxidation and reduced levels of antioxidants. The activities of membrane-bound enzymes are affected by oxidative stress. Taurine, a sulfur containing amino acid is shown to have hypoglycemic activity, antioxidant property and membrane stabilization. The aim of the study is to check the effect of supplementation of taurine on lipid peroxidation, antioxidant status and hepatic membrane-bound enzymes in streptozotocin- induced diabetic rats. Materials and Methods: Thirty-two Wistar male albino rats of 19±1 weeks of age weighing 200-220 grams were randomly divided into four groups and each group consisted of eight animals. Group I (control) standard chow diet; Group II (chow diet with taurine); Group III (diabetes induced) and Group IV (diabetic receiving taurine). At the end of 45th day, all animals were sacrificed by cervical decapitation after overnight fasting. Blood and liver tissue samples were collected. The levels of glucose in plasma and lipid peroxidation, antioxidants and the activities of Na+/ K+, Ca2+ and Mg2+-ATPases in liver homogenate were analyzed. Results: Altered levels of antioxidants and activities of Na+/ K+, Ca2+ and Mg2+-ATPases were restored to normal by taurine supplementation in diabetic rats. Conclusion: The present study indicates that supplementation of taurine could protect liver plasma membrane against oxidative damage by acting as antioxidant and restoring the normal activities of Na+/ K+, Ca2+ and Mg2+-ATPases.  

Short-Term Exposure to Nickel Alters the Adult Rat Brain Antioxidant Status and the Activities of Crucial Membrane-Bound Enzymes: Neuroprotection by L-Cysteine

2011 ◽  
Vol 143 (3) ◽  
pp. 1673-1681 ◽  
Author(s):  
Charis Liapi ◽  
Apostolos Zarros ◽  
Stamatios Theocharis ◽  
Konstantinos Voumvourakis ◽  
Foteini Anifantaki ◽  
...  
Keyword(s):  
Rat Brain ◽  
Antioxidant Status ◽  
Short Term ◽  
Adult Rat ◽  
Short Term Exposure ◽  
Adult Rat Brain ◽  
Membrane Bound ◽  
Membrane Bound Enzymes

Baicalein improves antioxidant status and membrane-bound enzymes during oxidative stress in benzo(a)pyrene-induced lung carcinogenesis in mice

2012 ◽  
Vol 2 (2) ◽  
pp. 138-144 ◽  
Author(s):  
Chandrashekar Naveenkumar ◽  
Subramanian Raghunandhakumar ◽  
Selvamani Asokkumar ◽  
John Binuclara ◽  
Thiruvengadam Devaki
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Lung Carcinogenesis ◽  
Membrane Bound ◽  
Membrane Bound Enzymes

Alterations in rat erythrocyte membrane due to hexachlorocyclohexane (technical) exposure

1998 ◽  
Vol 17 (11) ◽  
pp. 638-642 ◽  
Author(s):  
Pankaj Bhalla ◽  
Deepa Agrawal
Keyword(s):  
Membrane Fluidity ◽  
Erythrocyte Membrane ◽  
Osmotic Fragility ◽  
Structure And Function ◽  
Membrane Structure And Function ◽  
Hydrophobic Molecule ◽  
Erythrocyte Membrane Fluidity ◽  
Membrane Bound ◽  
And Function ◽  
Membrane Bound Enzymes

1 Hexachlorocyclohexane (HCH), an organochlorine pesticide having hydrophobic molecule is known to act on membranes. HCH mediated alterations in erythrocyte membrane occur through disorganization of the lipid bilayer. Therefore the changes in erythrocyte membrane fluidity, osmotic fragility and certain membrane bound enzymes were studied. Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility anddecreaseinlevelsofNa+, K+-ATPase, acetylcholinesterase in erythrocytes and glutathione in blood. 2 These changes indicate that HCH adversely affects membrane structure and function.

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