scholarly journals Preparation and In vitro evaluation of a stomach specific drug delivery system based on superporous hydrogel composite

2011 ◽  
Vol 73 (1) ◽  
pp. 30 ◽  
Author(s):  
HV Chavda ◽  
CN Patel
2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Hitesh Chavda ◽  
Ishan Modhia ◽  
Anant Mehta ◽  
Rupal Patel ◽  
Chhagan Patel

Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 32full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content,in vitrodrug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.


2021 ◽  
Vol 28 (3) ◽  
pp. 359-359
Author(s):  
Hongfei Liu ◽  
Jie Zhu ◽  
Pengyue Bao ◽  
Yueping Ding ◽  
Jiapeng Wang ◽  
...  

The authors are regretful for submitting and approving the publication of incorrect Figure 4 in this article. Below is the corrected version along with the revised caption. The electronic version of the article has already been corrected.


2017 ◽  
Vol 12 (1) ◽  
pp. 166-187 ◽  
Author(s):  
Wenliang Fu ◽  
Mohd Hezmee Mohd Noor ◽  
Loqman Mohamad Yusof ◽  
Tengku Azmi Tengku Ibrahim ◽  
Yeap Swee Keong ◽  
...  

2020 ◽  
Vol Volume 15 ◽  
pp. 5217-5226 ◽  
Author(s):  
Chen Jianxian ◽  
Kalsoom Saleem ◽  
Muhammad Ijaz ◽  
Masood Ur-Rehman ◽  
Ghulam Murtaza ◽  
...  

2019 ◽  
Vol 53 ◽  
pp. 101144 ◽  
Author(s):  
Simona Giarra ◽  
Noemi Lupo ◽  
Virginia Campani ◽  
Alfonso Carotenuto ◽  
Laura Mayol ◽  
...  

2012 ◽  
Vol 161 (3) ◽  
pp. 927-932 ◽  
Author(s):  
D. Hernán Pérez de la Ossa ◽  
A. Ligresti ◽  
M.E. Gil-Alegre ◽  
M.R. Aberturas ◽  
J. Molpeceres ◽  
...  

2012 ◽  
Vol 42 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Robhash Kusam Subedi ◽  
Je-Phil Ryoo ◽  
Cheol Moon ◽  
Myung-Kwan Chun ◽  
Hoo-Kyun Choi

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