Cardioprotective effect of methanolic extract of Ixora coccinea Linn. leaves on doxorubicin-induced cardiac toxicity in rats

Jingini - Lannea coromandelica Merr. (Houtt) is mentioned in Bhava Prakasha Nighantu and Bhavamishra advocates JINGINI for Hridroga. An experimental study was designed with a Model - Isoproterenol (ISO) Induced Cardiac toxicity in order to prove the efficacy of JINGINI for its Cardioprotective activity. Animals were administered with Aqueous and Methanolic extract of JINIGINI in higher and lower dose. The Acute toxicity studies were conducted up to 5000 mg/kg body weight in accordance with OECD 425 guidelines. The higher dose calculated from 1/5th of 5000 mg/kg body weight which summed up to 1000 mg/kg body weight and lower dose calculated from 1/10th of 5000 mg/kg body weight was concluded as 500 mg/kg body weight. The Methanolic extract of JINGINI in Higher and Lower dose (1000 mg/kg body weight and 500 mg /kg body weight respectively) was found to be efficacious in providing the Cardio-protective action in SD Rats.

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Cardioprotective Effect of Quercetin and Sitagliptin in Doxorubicin-Induced Cardiac Toxicity in Rats

Cancer Management and Research ◽

10.2147/cmar.s300495 ◽

2021 ◽

Vol Volume 13 ◽

pp. 2349-2357

Author(s):

Tavga Ahmed Aziz

Keyword(s):

Cardiac Toxicity ◽

Cardioprotective Effect

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Cardioprotective effect of magnetic hydrogel nanocomposite loaded N,α-L-rhamnopyranosyl vincosamide isolated fromMoringa oleiferaleaves against doxorubicin-induced cardiac toxicity in rats:in vitroandin vivostudies

Journal of Microencapsulation ◽

10.1080/02652048.2017.1311955 ◽

2017 ◽

Vol 34 (4) ◽

pp. 335-341 ◽

Cited By ~ 11

Author(s):

Mostafa Cheraghi ◽

Mehrdad Namdari ◽

Hadis Daraee ◽

Babak Negahdari

Keyword(s):

Cardiac Toxicity ◽

Cardioprotective Effect ◽

Magnetic Hydrogel ◽

Hydrogel Nanocomposite

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Cardioprotective Effect of High-Intensity Aerobic Interval Training against Adriamycin-Induced Cardiac Toxicity in Rats

Journal of Clinical Research in Paramedical Sciences ◽

10.5812/jcrps.83850 ◽

2019 ◽

Vol 8 (1) ◽

Author(s):

Khadijeh Ebrahimi ◽

Siroos Choobineh ◽

Rahman Soori ◽

Reza Badalzadeh

Keyword(s):

High Intensity ◽

Cardiac Toxicity ◽

Interval Training ◽

Cardioprotective Effect ◽

Aerobic Interval Training

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ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF IXORA COCCINEA FLOWER

INDIAN DRUGS ◽

10.53879/id.50.01.p0064 ◽

2013 ◽

Vol 50 (01) ◽

pp. 64-67

Author(s):

A.N. Aher ◽

◽

S. C Pal ◽

S. A. Muke

Keyword(s):

Oral Administration ◽

Analgesic Activity ◽

Methanolic Extract ◽

Quantitative Estimation ◽

Paw Edema ◽

Polyphenolic Content ◽

Total Polyphenolic Content ◽

Anti Inflammatory ◽

Ixora Coccinea

The present study was an endeavor to evaluate anti-inflammatory and analgesic activity of methanolic extract of Ixora coccinea flowers (ICF-ME). The in vivo anti-inflammatory was evaluated in rats by using carageenan-induced paw edema, as an acute anti-inflammatory model. Quantitative estimation of total polyphenolic content of I. coccinea flowers was estimated by ICF-ME (100 mg/kg) significantly decreased paw volume, after oral administration of ICF-ME in carrageenan injection. ICF-ME also exhibit significant analgesic activity. The response of licking or jumping latency was recorded in seconds by using hotplate method. Presence of phytochemical like flavonoids, glycosides, and tannins in the ICF-ME might contribute to the observed analgesic and anti-inflammatory activity.

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