scholarly journals Human metapneumovirus and human coronavirus infection and pathogenicity in Saudi children hospitalized with acute respiratory illness

2011 ◽  
Vol 31 (5) ◽  
pp. 523-527 ◽  
Author(s):  
Sami Al Hajjar ◽  
Sahar Al Thawadi ◽  
Amal Al Seraihi ◽  
Saleh Al Muhsen ◽  
Hala Imambaccus
Keyword(s):  
Respiratory Illness ◽  
Human Metapneumovirus ◽  
Acute Respiratory Illness ◽  
Human Coronavirus ◽  
Coronavirus Infection

scholarly journals Inhibition of Human Coronavirus NL63 Infection at Early Stages of the Replication Cycle

2006 ◽  
Vol 50 (6) ◽  
pp. 2000-2008 ◽  
Author(s):  
Krzysztof Pyrc ◽  
Berend Jan Bosch ◽  
Ben Berkhout ◽  
Maarten F. Jebbink ◽  
Ronald Dijkman ◽  
...  
Keyword(s):  
Respiratory Illness ◽  
Intravenous Immunoglobulins ◽  
Replication Cycle ◽  
Heptad Repeat ◽  
Effective Vaccine ◽  
Cellular Receptor ◽  
Acute Respiratory Illness ◽  
Human Coronavirus ◽  
Synthetic Compounds ◽  
Multiple Stages

ABSTRACT Human coronavirus NL63 (HCoV-NL63), a recently discovered member of the Coronaviridae family, has spread worldwide and is associated with acute respiratory illness in young children and elderly and immunocompromised persons. Further analysis of HCoV-NL63 pathogenicity seems warranted, in particular because the virus uses the same cellular receptor as severe acute respiratory syndrome-associated coronavirus. As there is currently no HCoV-NL63-specific and effective vaccine or drug therapy available, we evaluated several existing antiviral drugs and new synthetic compounds as inhibitors of HCoV-NL63, targeting multiple stages of the replication cycle. Of the 28 compounds that we tested, 6 potently inhibited HCoV-NL63 at early steps of the replication cycle. Intravenous immunoglobulins, heptad repeat 2 peptide, small interfering RNA1 (siRNA1), siRNA2, β-d -N 4-hydroxycytidine, and 6-azauridine showed 50% inhibitory concentrations of 125 μg/ml, 2 μM, 5 nM, 3 nM, 400 nM, and 32 nM, respectively, and low 50% cytotoxicity concentrations (>10 mg/ml, >40 μM, >200 nM, >200 nM, >100 μM, and 80 μM, respectively). These agents may be investigated further for the treatment of coronavirus infections.

scholarly journals Human Metapneumovirus Infection among Children Hospitalized with Acute Respiratory Illness

2004 ◽  
Vol 10 (4) ◽  
pp. 700-705 ◽  
Author(s):  
James A. Mullins ◽  
Dean D. Erdman ◽  
Geoffrey A. Weinberg ◽  
Kathryn Edwards ◽  
Caroline B. Hall ◽  
...  
Keyword(s):  
Respiratory Illness ◽  
Human Metapneumovirus ◽  
Acute Respiratory Illness

scholarly journals Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease

2009 ◽  
Vol 199 (6) ◽  
pp. 847-857 ◽  
Author(s):  
Geoffrey J. Gorse ◽  
Theresa Z. O’Connor ◽  
Susan L. Hall ◽  
Joseph N. Vitale ◽  
Kristin L. Nichol
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Older Adults ◽  
Pulmonary Disease ◽  
Respiratory Illness ◽  
Chronic Obstructive ◽  
Acute Respiratory Illness ◽  
Human Coronavirus ◽  
Obstructive Pulmonary Disease

scholarly journals Prevalence and molecular epidemiology of human coronavirus HKU1 in patients with acute respiratory illness

2012 ◽  
Vol 85 (2) ◽  
pp. 309-314 ◽  
Author(s):  
Wan-Ji Lee ◽  
Yoon-Seok Chung ◽  
Hee Sook Yoon ◽  
Chun Kang ◽  
Kisoon Kim
Keyword(s):  
Molecular Epidemiology ◽  
Respiratory Illness ◽  
Acute Respiratory Illness ◽  
Human Coronavirus

scholarly journals Human Coronavirus in Young Children Hospitalized for Acute Respiratory Illness and Asymptomatic Controls

2012 ◽  
Vol 31 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Mila M. Prill ◽  
Marika K. Iwane ◽  
Kathryn M. Edwards ◽  
John V. Williams ◽  
Geoffrey A. Weinberg ◽  
...  
Keyword(s):  
Young Children ◽  
Respiratory Illness ◽  
Acute Respiratory Illness ◽  
Human Coronavirus

scholarly journals Coronavirus infection and hospitalizations for acute respiratory illness in young children

2009 ◽  
Vol 81 (5) ◽  
pp. 853-856 ◽  
Author(s):  
H. Keipp B. Talbot ◽  
James E. Crowe ◽  
Kathryn M. Edwards ◽  
Marie R. Griffin ◽  
Yuwei Zhu ◽  
...  
Keyword(s):  
Young Children ◽  
Respiratory Illness ◽  
Acute Respiratory Illness ◽  
Coronavirus Infection

scholarly journals Epidemiological and clinical features of human metapneumovirus in hospitalised paediatric patients with acute respiratory illness: a cross-sectional study in Southern China, from 2013 to 2016

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e019308 ◽  
Author(s):  
Ling Zhang ◽  
Wenkuan Liu ◽  
Donglan Liu ◽  
Dehui Chen ◽  
Weiping Tan ◽  
...  
Keyword(s):  
Clinical Features ◽  
Southern China ◽  
Respiratory Illness ◽  
Cross Sectional Study ◽  
Human Metapneumovirus ◽  
Main Diagnosis ◽  
Acute Respiratory Illness ◽  
Sectional Study ◽  
Cross Sectional ◽  
Paediatric Patients

ObjectivesHuman metapneumovirus (HMPV) is one of the most important respiratory viral pathogens affecting infants and children worldwide. Our study describes the epidemiological and clinical characteristics of HMPV present in patients hospitalised with acute respiratory illness (ARI) in Guangzhou, Southern China.Study designA cross-sectional study.SettingTwo tertiary hospitals in Guangzhou.Participants and methodsThroat swabs were collected over a 3-year period from 5133 paediatric patients (≤14 years) hospitalised with ARI. Patients who are HMPV positive with clinical presentations (101/103) were recorded for further analysis.ResultsOf the 5133 patients included in the study, 103 (2.0%) were positive for HMPV. HMPV was more prevalent in children ≤5 years (2.2%, 98/4399) compared with older children (>5–14 years) (0.7%, 5/734) (P=0.004). Two seasonal HMPV peaks were observed each year and mainly occurred in spring and early summer. Overall, 18.4% (19/103) of patients who are HMPV positive were codetected with other pathogens, most frequently respiratory syncytial virus (36.8%, 7/19). Patients who are HMPV positive presented with a wide spectrum of clinical features, including cough (100.0%, 101/101), abnormal pulmonary breath sound (91.1%, 92/101), fever (88.1%, 89/101), expectoration (77.2%, 78/101), coryza (50.5%, 51/101) and wheezing (46.5%, 47/101). The main diagnosis of patients who are HMPV positive was bronchopneumonia (66.7%, 56/84). Fever (≥38˚C) (91.6%, 76/83) was detected more often in patients with only HMPV detected than in patients with HMPV plus other pathogen(s) detected (72.2%, 13/18) (P=0.037), whereas diarrhoea was more common in patients with HMPV plus other pathogen(s) detected (22.2%, 4/18), compared with patients with HMPV only (3.6%, 3/83) (P=0.018).ConclusionsHMPV is an important respiratory pathogen in children with ARI in Guangzhou, particularly in children ≤5 years old. HMPV has a seasonal variation. Bronchopneumonia is a major diagnosis in patients who are HMPV positive.

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