scholarly journals Hepatitis C virus (HCV) infection & risk factors for HCV positivity in injecting & non-injecting drug users attending a de-addiction centre in northern India

2015 ◽  
Vol 142 (3) ◽  
pp. 311 ◽  
Author(s):  
Debasish Basu ◽  
ArunKumar Sharma ◽  
Sunil Gupta ◽  
Naresh Nebhinani ◽  
Vineet Kumar
1994 ◽  
Vol 70 (5) ◽  
pp. 321-324 ◽  
Author(s):  
I van Beek ◽  
R Buckley ◽  
M Stewart ◽  
M MacDonald ◽  
J Kaldor

2011 ◽  
Vol 55 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Jason Grebely ◽  
Gail V. Matthews ◽  
Margaret Hellard ◽  
David Shaw ◽  
Ingrid van Beek ◽  
...  

2020 ◽  
Author(s):  
Robert Onchong'a Mainga ◽  
Odari Okoth Eddy ◽  
Borus Kimutai Peter ◽  
Ole Kwallah Allan ◽  
Murith Gikunda James ◽  
...  

Abstract Background: Hepatitis C virus is a major global health problem estimated to infect over 170 million people globally with the most common route of infection being injecting drug use (IDU). Treatment for HCV infection has traditionally been shown to be genotype specific; however the available drugs are still expensive and out of reach in many developing countries. To improve on monitoring, there is need to continuously document the genotypic burden and epidemiology in different populations arises. Objectives: This study aimed to determine the circulating genotypes and link the data to the socio-demographics of injecting drug users in Kilifi County along the Kenyan coastline. Methods: Using a random sampling method, this was a cross-sectional prospective study conducted among 127 injecting drug users, whereby ethical clearance was sought from Kenyatta National Hospital/ University of Nairobi Ethical and Research review committee (KNH/UON-ERC), and Reference number P366/07/2017 on 25 th September 2017. Serology for HCV was done followed by nucleic acid amplification and eventual genotyping. Socio-demographic data was collected using questionnaire administered at the sites. Results: A total of 28 (23 males and 5 females) samples out of 127 samples were positive for HCV giving a prevalence of 22.1%. The modal age group was 25- 49 years. Of the positive samples, 11 were amplified by PCR, all from the male IDUs. Prevalent genotypes included genotype 1a (13%) and genotype 4a (87%). Both genotype 1a and 4a were only found in males. Conclusion: Although it is the first time to report HCV4a in Kilifi town and Mtwapa as compared to Watamu and Malindi which had both HCV1a and HCV4a. Tourists born in countries where HCV prevalence is high are supposed to be screened before accessing entry to Kilifi County. No clinical trial was conducted. The study reveals the burden of HCV infection among IDUs in Kilifi County. The Government should formulate policies for intervention on testing and treatment of HCV in Kilifi County targeting IDUs in order to minimize spread to other populations.


2005 ◽  
Vol 16 (11) ◽  
pp. 749-754 ◽  
Author(s):  
Tim Rhodes ◽  
Lucy Platt ◽  
Ali Judd ◽  
Larissa Albertovna Mikhailova ◽  
Anya Sarang ◽  
...  

The objective of this study was to estimate the prevalence of hepatitis C virus (HCV) infection and co-infection with HIV among injecting drug users (IDUs) in Togliatti City, Russia. Unlinked anonymous cross-sectional survey of IDUs recruited from community settings, with oral fluid sample collection for HCV and HIV antibody (anti-HCV, anti-HIV) testing, was carried out. The anti-HCV prevalence was 87% (357/411), anti-HIV prevalence 56% (234/418), and 93% (214/230) of HIV-positive IDUs were co-infected with HCV. Only 23% (94/411) of those HCV positive self-reported as such. In an adjusted model, increased odds of HCV positivity were associated with needle and syringe, as well as injecting paraphernalia sharing in the last four weeks. IDUs injecting more than once with the same needle also had raised odds. There were no marked associations between HCV positivity and the duration of injecting or age group. Almost all IDUs were HCV positive, and almost all HIV-positive IDUs were HCV co-infected. There is an urgent need to maximize syringe distribution coverage, develop health promotion targeting HCV prevention for IDUs, and improve access among IDUs to treatments for HIV and HCV infection.


1970 ◽  
Vol 25 (3) ◽  
pp. 126-129 ◽  
Author(s):  
Shahinul Alam ◽  
Nooruddin Ahmad ◽  
Mobin Khan ◽  
Golam Mustafa

Background and aims: Parenteral route is the principal mode of transmission of Hepatitis C Virus (HCV). Health care workers are at risk of infection with HCV. Aim of study was to estimate seroprevalence of HCV amongst health care workers and identify possible risk factors of HCV infection. Materials and Methods: 355 health care workers were selected from July 2005 to June 2006 working in different departments of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Among them 43.5% were doctors, 32.1% nurses, 11.8% ward boys, 5.9% operation theatre staffs (OT staffs), and 6.8% others. Sera were tested for HCV antibodies by ELISA. Data analyzed by SPSS 10.0 version. Results: Mean age was 31.56±7.4 years. Males were 51.4% and females 48.6%. Anti-HCV was positive in 5(1.4%) cases out of 355. Most prone to HCV infection were nurses (3) followed by doctor (2). No ward boy or OT staff was affected. Previous surgical (80%) and dental procedures (60%) were the main risk factors than recipients of blood transfusion (20%), intravenous drug users (20%), and multiple sexual exposures (20%). Conclusions: Nurses are more prone to HCV infection. Surgical procedures are the main risk factors for acquiring HCV infection. Proper sterilization of surgical instruments is recommended. (J Bangladesh Coll Phys Surg 2007; 25 : 126-129)


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