scholarly journals Absorbed dose assessment of177Lu-zoledronate and177Lu-EDTMP for human based on biodistribution data in rats

2015 ◽  
Vol 40 (2) ◽  
pp. 102 ◽  
Author(s):  
Samaneh Zolghadri ◽  
AmirReza Jalilian ◽  
Hassan Yousefnia
Keyword(s):  
Absorbed Dose ◽  
Dose Assessment ◽  
Biodistribution Data

Preliminary dosimetric evaluation of 90Y-BPAMD as a potential agent for bone marrow ablative therapy

2018 ◽  
Vol 18 (1) ◽  
pp. 70-74
Author(s):  
Ali Rabiei ◽  
Hassan Yousefnia ◽  
Samaneh Zolghadri ◽  
Mojtaba Shamsaei
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Ablative Therapy ◽  
Red Marrow ◽  
Biodistribution Data ◽  
Bone Marrow Ablation ◽  
Therapeutic Tools ◽  
Marrow Ablation

AbstractAimBone-seeking radiopharmaceuticals are potential therapeutic tools for bone marrow ablation in patients with multiple myeloma. In this procedure, estimation of radiation absorbed dose received by the target and non-target organs is one of the most important parameters that should be undertaken. This research revolves around the absorbed dose to human organs after 90Y-BPAMD injection.Materials and methods90Y-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (90Y-BPAMD) complex was successfully prepared under optimised conditions. The human absorbed dose of the complex was estimated based on the biodistribution data on rats using the radiation-absorbed dose-assessment resource method. The target to non-target absorbed dose ratios for the complex was compared with the ratios for 166Ho-DOTMP, as the main radiopharmaceutical for bone marrow ablation.ResultsAs expected, the highest amounts of absorbed dose were observed in the bone surface and the bone marrow with 2·52 and 2·29 mGy/MBq, respectively. The red marrow to the most organ absorbed dose ratios for 90Y-BPAMD are much higher than the ratios for 166Ho-DOTMP.Findings90Y-BPAMD has interesting characteristics compared with 166Ho-DOTMP and can be considered as a high potential agent for bone marrow ablative therapy of the patient with multiple myeloma.

ESTIMATION OF HUMAN DOSE OF 188/186RE-HEDP COCKTAIL BASED ON OLINDA/EXM AND DISTRIBUTION DATA IN RATS

2020 ◽  
Vol 190 (2) ◽  
pp. 158-164
Author(s):  
Zahra Pourhabib ◽  
Hassan Ranjbar ◽  
Ali Bahrami Samani
Keyword(s):  
Radiation Dose ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Distribution Data ◽  
Time Intervals ◽  
Human Organs ◽  
Human Dose ◽  
Biodistribution Data ◽  
Absorbed Radiation Dose ◽  
Assessment Resource

Abstract 188Re and 186Re are two applicable rhenium medical radioisotopes with complementary features that make them beneficial for different sizes of tumours. The aim of this study is to investigate 188/186Re-HEDP efficacy as a cocktail by calculating absorbed radiation dose in human organs based on biodistribution data obtained by injecting it to normal rats. Three rats were sacrificed at different time intervals and the percentage of injected dose per gram of each organ was measured by direct counting from rat data. By calculating accumulated activities in each organ and extrapolating rat data to human data by the radiation dose assessment resource method and by using OLINDA/EXM software, the injected dose in various human organs was obtained. The calculated absorbed dose showed that the 188/186Re-HEDP has noticeable properties that can be more helpful in comparison with using each of the rhenium radioisotopes separately.

Human Absorbed Dose Evaluation of [177Lu]Lu-IBA as a Bone Palliative Candidate

2021 ◽  
Author(s):  
Hassan Ranjbar ◽  
Zahra Pourhabib
Keyword(s):  
Radiochemical Purity ◽  
Palliative Therapy ◽  
Absorbed Dose ◽  
Skeletal Metastases ◽  
Clinical Pharmacokinetics ◽  
Thermal Neutron Irradiation ◽  
Biodistribution Data ◽  
Biological Studies ◽  
Significant Uptake

AbstractThe role of lutetium-177 among bone-seeking radionuclides in targeted therapy is noteworthy. The clinical pharmacokinetics of ibandronate (IBA) indicates that this bisphonate has powerful bone mineral affinity. The aim of this study was to evaluate of [177Lu]Lu-IBA efficacy as a new compound.The [177Lu]Lu-IBA was prepared by radiolabeling of IBA ligand to 177LuCl3 that was obtained by thermal neutron irradiation of enriched Lu2O3 sample. Produced [177Lu]Lu-IBA with high radiochemical purity was administered intravenously to mice. Biodistribution data were collected at 1, 4, 24, 48 h and 7 d post injections. With calculating accumulated activities in each organ and extrapolating mouse’s organs to human’s organs by the RADAR method and using OLINDA/EXM software the injected dose in various human organs was achieved.[177Lu]Lu-IBA was produced with radiochemical purity nearly 96 %. Its biodistribution data showed the high uptake and durability in the skeletal tissues without significant uptake in other major organs.The results showed that [177Lu]Lu-IBA has considerably good properties as a bone-seeking radiopharmaceutical and therefore can be a candidate for bone pain palliative therapy in skeletal metastases; however, further biological studies are still needed.

scholarly journals A comparison of in-air and in-water calibration of a dosimetry system used for radiation dose assessment in cancer therapy

2010 ◽  
Vol 25 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Waheed Arshed ◽  
Khalid Mahmood ◽  
Ikramullah Qazi ◽  
Asad Ullah ◽  
Perveen Akhter ◽  
...  
Keyword(s):  
Radiation Dosimetry ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Dose Delivery ◽  
Air Kerma ◽  
Tissue Equivalent ◽  
Dosimetry System ◽  
Irradiation Geometry ◽  
Radiation Dose Assessment ◽  
Absorbed Dose To Water

An accurate calibration of the therapy level radiation dosimetry system has a pivotal role in the accuracy of dose delivery to cancer patients. The two methods used for obtaining a tissue equivalent calibration of the system: air kerma calibration and its conversion to a tissue equivalent value (absorbed dose to water) and direct calibration of the system in a water phantom, have been compared for identical irradiation geometry. It was found that the deviation between the two methods remained within a range of 0% to ?1.7% for the PTW UNIDOS dosimetry system. This means that although the recommended method is in-water calibration, under exceptional circumstances, in-air calibration may be used as well.

scholarly journals Hybrid Imaging Reveals Improved Absorbed Dose from Selective Internal Radiation Treatment by Using an Anti-Reflux Catheter

2020 ◽  
Author(s):  
Esmaeel Jafargholi Rangraz ◽  
Xikai Tang ◽  
Geert Maleux ◽  
Jeroen Dekervel ◽  
Eric Van Cutsem ◽  
...  
Keyword(s):  
Hybrid Imaging ◽  
Radiation Treatment ◽  
Standard Procedure ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Treatment Result ◽  
Activity Measurement ◽  
Internal Radiation ◽  
Dose Volume Histograms ◽  
Selective Internal Radiation

Abstract Selective internal radiation therapy (SIRT) is a promising technique for patients with hepatic malignancies. Several image-based investigations, e.g. volumetric and absorbed dose assessment, are mandatory for SIRT planning and treatment verification based on national and international regulations.General treatment workflows are described in guidelines, recommendations, and the package inserts of the manufactures. But, guidance to tackle particular clinical conditions can be ill-defined and different centers practice their own workflow to analyze the treatment process. This case report includes an example of inconsistency between treatment simulation and observed treatment result, revealed by hybrid imaging. There is no universally accepted standard procedure defined in the literature for detecting and evaluating a possible mismatch between [99mTc]Tc-MAA-based simulation and distribution of the therapeutic microspheres. In this setting, more advanced multi-modal image-based analysis may be beneficial.A 78 year old patient with hepatocellular carcinoma underwent liver radioembolization with resin 90Y-microspheres. Tumoral and non-tumoral dose–volume histograms were evaluated for simulated activity distribution using [99mTc]Tc-MAA-SPECT and post-treatment activity measurement using 90Y-PET. During simulation workup, [99mTc]Tc-MAA particles were administered using a regular catheter. On the other hand, for the treatment session an anti-reflux catheter was used. Our result, suggests that the use of an anti-reflux catheter might improve tumor coverage, and as a result decrease non-tumoral liver uptake deposition.

MODELLING AND SIMULATION FOR RADIOLOGICAL DOSE ASSESSMENT OF PSAMMOTHERAPY AND CLIMATOTHERPY

2020 ◽  
Vol 188 (3) ◽  
pp. 276-284
Author(s):  
Kh A Allam
Keyword(s):  
Reference Point ◽  
Gamma Ray ◽  
Natural Radionuclides ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Beach Sand ◽  
Dose Rates ◽  
Occupational Dose ◽  
Mathematical Simulations ◽  
Radiological Dose

Abstract Patient and occupational dose rates due to psammotherapy (sand therapy) and climatotherapy treatments in high natural background areas in Egypt have been evaluated. Monte Carlo mathematical simulations using adult human phantoms were applied to consider the effect of elevated 238U, 232Th and 40K concentrations and the nonhomogeneous distribution of natural radionuclides in beach sand. Three situations: phantom covered by sand or lying on the beach and points in air at several heights above sand level, were considered. The gamma-ray doses per treatment were calculated at a reference point located on the phantom surface centrally above the genital area. The thus calculated patient-absorbed-dose ranges at this reference point were 0.006–0.018 mGy and 0.004–0.023 mGy per climatotherapy and psammotherapy treatments, respectively.

scholarly journals 90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy

2010 ◽  
Vol 51 (12) ◽  
pp. 1974-1978 ◽  
Author(s):  
D. Minarik ◽  
K. Sjogreen-Gleisner ◽  
O. Linden ◽  
K. Wingardh ◽  
J. Tennvall ◽  
...  
Keyword(s):  
Absorbed Dose ◽  
Dose Assessment ◽  
High Dose

scholarly journals Uncertainty analysis of tumour absorbed dose calculations in molecular radiotherapy

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Domenico Finocchiaro ◽  
Jonathan I. Gear ◽  
Federica Fioroni ◽  
Glenn D. Flux ◽  
Iain Murray ◽  
...  
Keyword(s):  
Uncertainty Analysis ◽  
Spatial Resolution ◽  
Absorbed Dose ◽  
Dose Assessment ◽  
Dose Calculations ◽  
Time Activity ◽  
Molecular Radiotherapy ◽  
Wide Range ◽  
Dose Uncertainty ◽  
The Impact

Abstract Background Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical routine. However, it is essential for adequate interpretation of the results. Recently, the EANM published a practical guidance on uncertainty analysis for molecular radiotherapy based on the application of the law of propagation of uncertainty. In this study, we investigated the overall uncertainty on a sample of a patient following the EANM guidelines. The aim of this study was to provide an indication of the typical uncertainties that may be expected from performing dosimetry, to determine parameters that have the greatest effect on the accuracy of calculations and to consider the potential improvements that could be made if these effects were reduced. Results Absorbed doses and the relative uncertainties were calculated for a sample of 49 patients and a total of 154 tumours. A wide range of relative absorbed dose uncertainty values was observed (14–102%). Uncertainties associated with each quantity along the absorbed dose calculation chain (i.e. volume, recovery coefficient, calibration factor, activity, time-activity curve fitting, time-integrated activity and absorbed dose) were estimated. An equation was derived to describe the relationship between the uncertainty in the absorbed dose and the volume. The largest source of error was the VOI delineation. By postulating different values of FWHM, the impact of the imaging system spatial resolution on the uncertainties was investigated. Discussion To the best of our knowledge, this is the first analysis of uncertainty in molecular radiotherapy based on a cohort of clinical cases. Wide inter-lesion variability of absorbed dose uncertainty was observed. Hence, a proper assessment of the uncertainties associated with the calculations should be considered as a basic scientific standard. A model for a quick estimate of uncertainty without implementing the entire error propagation schema, which may be useful in clinical practice, was presented. Ameliorating spatial resolution may be in future the key factor for accurate absorbed dose assessment.

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