Role of vascular endothelial growth factor and other growth factors in post-stroke recovery

The review covers the up-to-date data of vascular endothelial growth factor role in forming of placental blood circulation in non-complicated pregnancy and in fetal growth retardation syndrome. It is shown that the normal trophoblast invasion to the spiral arteries wall in the myometrium and adequate remodeling of spiral arteries are essential for the normal fetal growth and development. The processes of blood vessels formation - vasculogenesis and angiogenesis - are described in detail. The process of angiogenesis regulation by growth factors and their receptors is reviewed. The importance of angiogenic and antiangiogenic factors coordinated action for the adequate placental microvasculature formation and normal fetal development is described. The growth factor complexes and their receptors formation processes and competition for receptor binding, as well as the role of placental growth factor in uteroplacental complex angiogenesis are analyzed. It is shown that the serum growth factors represent the mechanisms of pathologic reactions in placental insufficiency and fetal growth restriction syndrome. Special attention is given to the family of vascular endothelial growth factor as for the most important angiogenesis regulator. To determine the physiological role of vascular endothelial growth factor and to assess the its influence on angiogenesis and adequate uteroplacental and fetoplacental blood circulation formation, the features of vascular endothelial growth factor chemical structure are described. Determining the vascular endothelial growth factor in blood may be used to assess the mother-placenta-fetus system formation. The need for developing the criteria for choosing the optimal delivery term in pregnant with fetal growth restriction syndrome is discussed.

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Role of Vascular Endothelial Growth Factor and Placental Growth Factors During Retinal Vascular Development and Hyaloid Regression

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.02-0040 ◽

2003 ◽

Vol 44 (2) ◽

pp. 839 ◽

Cited By ~ 34

Author(s):

Susan A. Feeney ◽

David A. C. Simpson ◽

Thomas A. Gardiner ◽

Cliona Boyle ◽

Pamela Jamison ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factors ◽

Growth Factor ◽

Vascular Development ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Role of the Heparin Binding Domain in the Clearance and Localization of Vascular Endothelial Growth Factor

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)88004-7 ◽

1998 ◽

Vol 31 (2) ◽

pp. 461A ◽

Cited By ~ 1

Author(s):

P Kimson

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Binding Domain ◽

Vascular Endothelial ◽

Heparin Binding ◽

Heparin Binding Domain ◽

Endothelial Growth Factor

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New insights on the role of vascular endothelial growth factor in biliary pathophysiology

JHEP Reports ◽

10.1016/j.jhepr.2021.100251 ◽

2021 ◽

Vol 3 (3) ◽

pp. 100251

Author(s):

Valeria Mariotti ◽

Romina Fiorotto ◽

Massimiliano Cadamuro ◽

Luca Fabris ◽

Mario Strazzabosco

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

Biomolecules ◽

10.3390/biom11020253 ◽

2021 ◽

Vol 11 (2) ◽

pp. 253

Author(s):

Xi Guo ◽

Hong Yi ◽

Tin Chiu Li ◽

Yu Wang ◽

Huilin Wang ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Recurrent Miscarriage ◽

Embryo Implantation ◽

Critical Role ◽

Angiogenic Factor ◽

Vascular Endothelial ◽

Underlying Mechanisms ◽

Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) is a well-known angiogenic factor that plays a critical role in various physiological and pathological processes. VEGF also contributes to the process of embryo implantation by enhancing embryo development, improving endometrial receptivity, and facilitating the interactions between the developing embryo and the endometrium. There is a correlation between the alteration of VEGF expression and reproductive failure, including recurrent implantation failure (RIF) and recurrent miscarriage (RM). In order to clarify the role of VEGF in embryo implantation, we reviewed recent literature concerning the expression and function of VEGF in the reproductive system around the time of embryo implantation and we provide a summary of the findings reported so far. We also explored the effects and the possible underlying mechanisms of action of VEGF in embryo implantation.

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