scholarly journals Nuclear factor kappa B activation and peroxisome proliferator-activated receptor transactivational effects of chemical components of the roots of Polygonum multiflorum

2016 ◽  
Vol 12 (45) ◽  
pp. 31 ◽  
Author(s):  
YoungHo Kim ◽  
YaNan Sun ◽  
Wei Li ◽  
SeokBean Song ◽  
XiTao Yan ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Chemical Components ◽  
Peroxisome Proliferator ◽  
Nuclear Factor ◽  
Polygonum Multiflorum ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nuclear Factor Kappa

scholarly journals Expressions of Nuclear Factor-kappa B and Peroxisome Proliferator-activated Receptor-Gamma Proportional with Clinical Staging of Nasopharyngeal Carcinoma

2021 ◽  
Vol 9 (B) ◽  
pp. 1347-1351
Author(s):  
Farhat Farhat ◽  
Elvita Rahmi ◽  
Jessy Chrestella ◽  
Osvaldo Williamson ◽  
Raudah Putri Syari
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Clinical Stage ◽  
Ppar Gamma ◽  
Clinical Staging ◽  
Peroxisome Proliferator ◽  
Nuclear Factor ◽  
Cross Sectional ◽  
Peroxisome Proliferator Activated Receptor ◽  
Nuclear Factor Kappa

BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignancy induced by the mutation of the transcription factors nuclear factor-kappa B (NF-kB) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma). There was no known of the study about the association and targeted therapy of NF-kB and PPAR-gamma-induced NPC. AIM: This study analyzed and compared the proportion of NF-kB and PPAR-gamma and its association with the clinical characteristic of various NPC patients. METHODS: This was a cross-sectional study and conducted in Adam Malik General Hospital. The samples were paraffin block tissue obtained from 58 NPC patients and underwent immunohistochemistry staining for NF-kB or PPAR-gamma overexpression in March–November 2018. Determination of overexpression was based on the immunoreactive score. The association of NF-kB or PPAR-gamma overexpression with the clinical characteristics of the patients was analyzed using Fisher’s exact test. RESULTS: This study showed a significant increase of NF-kB and PPAR-gamma (p < 0.05). Male was found common than women (3.46:1) with non-keratinizing squamous cell carcinoma as the most common form of NPC (75.9%) and the 41–60 years old is the most common age (56.9%). Overexpression of NF-kB and PPAR-gamma was found mostly in T3-T4 (66.0%; 69.6%), N+ (92.5%; 91.3%), and clinical Stage IV (67.9%; 73.9%), respectively. CONCLUSION: The number of samples overexpressed was proportional to the clinical stage of NPC. This study provides an insight into the relationship of NF-kB and PPAR-gamma to NPC, suggesting their role in the development of malignancy.

Chemical components from the seeds of Catalpa bungei and their inhibitions of soluble epoxide hydrolase, cholinesterase and nuclear factor kappa B activities

RSC Advances ◽  
2016 ◽  
Vol 6 (47) ◽  
pp. 40706-40716 ◽  
Author(s):  
Hao-Yu Tang ◽  
Meng-Meng Bai ◽  
Jun-Mian Tian ◽  
Gennaro Pescitelli ◽  
Trpimir Ivšić ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Nuclear Factor Kappa B ◽  
Soluble Epoxide Hydrolase ◽  
Chemical Components ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Catalpa Bungei

22 compounds, including two rare cage chlorinated iridoids, bungosides A (1) and B (2), were isolated fromCatalpa bungei. of soluble epoxide hydrolase (sEH), acetylcholinesterase (AChE) and BChE, and NF-κB activity.

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