Effects of ethanol extract of Pisonia aculeata Linn. on ehrlich ascites carcinoma tumor bearing mice

2008 ◽  
Vol 2 (1) ◽  
pp. 50 ◽  
Author(s):  
Raju Senthilkumar ◽  
Rangasamy Manivannan ◽  
Ayyasamy Balasubramaniam ◽  
Thangavel Sivakumar ◽  
Balasubramanian Rajkapoor
Keyword(s):  
Ethanol Extract ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Carcinoma Tumor

scholarly journals Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice

2014 ◽  
Vol 10 (4) ◽  
pp. 1071 ◽  
Author(s):  
ManishS Patel ◽  
BhaveshV Antala ◽  
Ena Dowerah ◽  
Raju Senthilkumar ◽  
Mangala Lahkar
Keyword(s):  
Antitumor Activity ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Carcinoma Tumor

Tube Leukocyte Adherence-Inhibition Response to Related and Unrelated Tumor Antigens in Mammary Tumor-Bearing Mice

1983 ◽  
Vol 69 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Utpala Chattopadhyay ◽  
Surajit Guha
Keyword(s):  
Mammary Tumor ◽  
Tumor Antigens ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Burden ◽  
Leukocyte Adherence ◽  
Tumor Bearing ◽  
Inhibition Response ◽  
Ehrlich Ascites ◽  
Leukocyte Adherence Inhibition ◽  
Adherence Inhibition

Tube leukocyte adherence-inhibition response to syngeneic mammary tumor antigens and alloantigens from Ehrlich ascites carcinoma and fibrosarcoma was studied in spontaneous mammary tumor-bearing C3H/Jax mice. The mice with limited tumor burden responded significantly to the mammary tumor antigen and the Ehrlich ascites carcinoma antigen. The reactivity disappeared with increased tumor load. Oscillatory responses in leukocyte adherence inhibition to the reactive antigens was observed with increasing tumor weight. There was no response to the alloantigen of fibrosarcoma.

THE MECHANISM OF PYRIDINE NUCLEOTIDE SYNTHESIS IN EHRLICH ASCITES CARCINOMA AND HOST LIVER

1967 ◽  
Vol 45 (2) ◽  
pp. 179-190 ◽  
Author(s):  
J. Purko ◽  
H. B. Stewart
Keyword(s):  
Nicotinic Acid ◽  
Ehrlich Ascites Carcinoma ◽  
Pyridine Nucleotide ◽  
Host Liver ◽  
Nucleotide Synthesis ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Metabolic Products ◽  
Ehrlich Ascites Cells ◽  
Specific Activities

Labeled nicotinamide–adenine dinucleotide (NAD) and nicotinic acid–adenine dinucleotide (NacAD) were identified following Dowex 2 (formate) chromatography of extracts of Ehrlich ascites cells and of livers of mice 3 and 6 h after injection of nicotinamide (Nam) (500 mg/kg) containing Nam-7-14C, and 3 h after injection of nicotinic acid (Nac) (50 mg/kg) containing Nac-7-14C into tumor-bearing animals. Labeled Nac mononucleotide (NacMN) was also identified in the liver extracts. The urinary metabolic products of the precursors were separated and partially characterized. Liver appeared to be somewhat more active in synthesis of NAD than tumor; the more efficient amidation of NacAD to NAD in liver probably contributes to this difference. The results are consistent with NacAD being an intermediate in NAD biosynthesis. Investigations of extracts of acetone powders of tumor provided evidence for two possible routes of synthesis (via NMN, and NacMN–NacAD): (1) Extracts incubated with Nam mononucleotide (NMN) and ATP formed NAD. (2) Extracts incubated with Nac-14C or Nam-14C with suitable supplementation gave rise to labeled NacMN, NacAD and NAD. These substances were isolated and their specific activities determined. Glutamine appeared to enhance NAD formation at the expense of NacAD. Although a net accumulation of NAD did not occur, the formation of Nam-14C from Nac-14C and the demonstration of NADase in the preparations suggested that NAD was formed but rapidly degraded.

Boswellic acid disables signal transduction of IL-6–STAT-3 in Ehrlich ascites tumor bearing irradiated mice

2016 ◽  
Vol 94 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Enas Mahmoud Moustafa ◽  
Noura Magdy Thabet ◽  
Khaled Shaaban Azab
Keyword(s):  
Signal Transduction ◽  
Caspase 3 ◽  
Tumor Tissue ◽  
Ehrlich Ascites Carcinoma ◽  
Boswellic Acid ◽  
Over Expression ◽  
Radiation Data ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Specific Impact

Boswellic acid (BA) is known for its ability to trigger apoptosis as well as to inhibit angiogenesis in tumor tissue. In this study, we investigated the effect of BA on the IL-6–STAT-3 signalling pathway in irradiated mice bearing solid tumors of Ehrlich ascites carcinoma (EAC). For this, we administered BA (25 mg·(kg body mass)–1·day–1, by intraperitoneal injection) to mice with EAC, and then exposed them to 4 Gy of gamma radiation. Data analyses of the results revealed a specific impact from BA on IL-6R mRNA and survivin mRNA in EACs and irradiated EAC-bearing mice. Also, significant improvements were observed in the protein expression of JAK-1, P-JAK-1, STAT-3, P-STAT-3, and caspase-3, as well as VEGF and IL-6 levels. We propose that BA interfered with IL-6–STAT-3 signal transduction, thereby preventing the activation of caspase-3 and subsequently triggering the process of apoptosis. However, the alternative angiogenesis pathway, which includes the over-expression of VEGF and which depends on IL-6–STAT-3 signalling, was inhibited by the action of BA. Thus, we recommend that therapeutic strategies for cancer should include treatment with BA.

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