scholarly journals Treatment of a non-healing diabetic foot ulcer with platelet-rich plasma

2014 ◽  
Vol 7 (4) ◽  
pp. 229 ◽  
Author(s):  
DeepakH Suresh ◽  
Shwetha Suryanarayan ◽  
Sacchidanand Sarvajnamurthy ◽  
Srikanth Puvvadi
Keyword(s):  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

Efficacy of Intra-Lesional Platelet Rich Plasma in Diabetic Foot Ulcer

2020 ◽  
Author(s):  
Ajay Gupta ◽  
Chethan Channaveera ◽  
Satyaranjan Sethi ◽  
Sunil Ranga ◽  
Vijender Anand
Keyword(s):  
Normal Saline ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Study Group ◽  
Ulcer Area ◽  
Total Contact Casting

Background: Diabetic foot ulcer (DFU) is well managed by infection control, euglycemic state, debridement of ulcer followed by appropriate dressing and off-loading of the foot. Studies have reported that when DFU is properly off-loaded, about 90% of these would heal in nearly six weeks. Platelet rich plasma (PRP) serves as a growth factor agonist and has mitogenic and chemotactic properties which help in DFU healing. To evaluate the efficacy of local application of PRP with respect to healing rate and ulcer area reduction in treating diabetic foot ulcer. Materials and Methods: Sixty non-infected DFU patients with plantar ulcer of size less than 20cm2 and Wagner's Grade 1 & 2 were randomized to receive normal saline dressing (Control group - CG) or PRP dressing (Study group - SG) in conjunction with total contact casting for 6 weeks (or till complete ulcer healing), whichever was earlier. Evaluation was done at weekly interval for healing rate and change in ulcer area.Results: Mean ulcer area of study participants at baseline was 4.96 {plus minus} 2.89cm2 (CG) and 5.22 {plus minus} 3.82cm2 (SG) (p=0.77) which decreased to 1.15{plus minus}1.35cm2 (CG) and 0.96{plus minus}1.53cm2 (SG) (p=0.432) at 6wks. Percent reduction in mean healing area at 6wks was 81.72{plus minus}17.2% and 85.98{plus minus}13.42% in control group and study group respectively (p=0.29). Average rate of healing achieved at 6 weeks was 0.64{plus minus}0.36cm2 and 0.71{plus minus}0.46cm2 in control group and study group respectively (p=0.734). Conclusions: PRP dressing is no more efficacious than normal saline dressing in management of DFU in conjunction with total contact casting.

Evaluation of wound healing in diabetic foot ulcer using platelet-rich plasma gel: A single-arm clinical trial

2017 ◽  
Vol 56 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Mohammad Hossein Mohammadi ◽  
Behnam Molavi ◽  
Saeed Mohammadi ◽  
Mohsen Nikbakht ◽  
Ashraf Malek Mohammadi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

Cost-effectiveness of Platelet-Rich Plasma for Diabetic Foot Ulcer in Spain

2020 ◽  
pp. 153473462090323
Author(s):  
Renata Linertová ◽  
Tasmania del Pino-Sedeño ◽  
Lidia-García Pérez ◽  
Javier Aragón-Sánchez ◽  
Isabel Andia-Ortiz ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Usual Care ◽  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Cost Effective ◽  
Manual Method ◽  
The Cost ◽  
Commercial Kit

This study evaluated the cost-effectiveness of platelet-rich plasma (PRP) added to usual care versus usual care alone in elderly patients with chronic diabetic foot ulcer (DFU) from the Spanish health care system perpective. A 6-state Markov model with 3-month cycles was used to estimate costs and outcomes of wound healing and risk of recurrences, infections, and amputations over 5 years. Three treatment strategies were compared: ( a) usual care plus PRP obtained with a commercial kit, ( b) usual care plus PRP obtained manually, and ( c) usual care. Data on effectiveness were taken from a recent meta-analysis. Outcomes and costs were discounted at 3% and resources were valued in 2018 euro. Compared with usual care, the PRP treatment with the manual method was more effective and less costly (dominant option), whereas the PRP treatment with the commercial kit was more effective but also more costly, with the incremental ratio being above the cost-effectiveness threshold (€57 916 per quality-adjusted life year). These results are sensitive to the price of PRP kits (a 20% discount would make the PRP treatment a cost-effective option) and effectiveness data, due to the heterogeneity of primary studies. In conclusion, PRP treatment for DFUs could be considered a cost-effective or even cost-saving alternative in Spain, depending on the method of obtaining the PRP. Despite the dominance of the manual method, its general use is limited to hospitals and specialized centers, whereas PRP kits could be used in primary care settings, but their prices should be negotiated by health authorities.

Accelerated healing of a diabetic foot ulcer using autologous stromal vascular fraction suspended in platelet-rich plasma

2018 ◽  
Vol 13 (3) ◽  
pp. 277-281 ◽  
Author(s):  
Triantafyllos Didangelos ◽  
George Koliakos ◽  
Kokkona Kouzi ◽  
George Arsos ◽  
Katerina Kotzampassi ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

scholarly journals Autologous derived, platelet-rich plasma gel in the treatment of nonhealing diabetic foot ulcer: a case report

2012 ◽  
Vol 3 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Torsten Slesaczeck ◽  
Hartmut Paetzold ◽  
Thomas Nanning ◽  
Andreas Reichel ◽  
Andreas Barthel ◽  
...  
Keyword(s):  
Case Report ◽  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

A COMPARATIVE STUDY OF PLATELET RICH PLASMA DRESSING VS NORMAL SALINE DRESSING IN THE MANAGEMENT OF DIABETIC FOOT ULCER

2021 ◽  
pp. 19-22
Author(s):  
Vijay kumar Siddalingappa ◽  
Mohan kumar Kariyappa ◽  
Subhashish Das
Keyword(s):  
Diabetic Foot ◽  
Platelet Rich Plasma ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Control Group ◽  
Diabetic Patients ◽  
Study Group ◽  
Diabetic Ulcer ◽  
Plantar Aspect ◽  
Diabetic Wounds

90 patients with diabetic foot ulcer admitted in Department of General Surgery R. L. JALAPPA HOSPITAL, TAMAKA, KOLAR, in between the study period of December 2017 to June 2019. The study is estimated to include diabetic foot ulcer patients satisfying inclusion criteria who are admitted in surgical wards of RLJH and RC. A complete detailed history, as per standard proforma will be obtained and documented. All patients will undergo clinical examination with relevant investigations after obtaining an informed consent. Patients are divided into 2 groups using even-odd method to include similar type of cases in both groups, where even group is study group and odd group is control group. RESULTS: Predisposition of diabetic foot ulcer was common among males than in females, More number of diabetic patients presented with diabetic foot ulcer arising from trauma than those occurring spontaneously. The spontaneous onset ulcers healed better with PRP than those arising due to traumatic onset. The ulcers on dorsal aspect heal faster than on plantar aspect, PRP dressing improved the rate of healing in lower Wagner grade ulcer than in higher grade ulcer, Patients who were on insulin alone showed better healing than those on OHA. Over all PRP dressing group showed higher rate of ulcer size reduction than those on saline dressing. CONCLUSION: The diabetic ulcer in the study group treated with PRP dressing contracted in wound size more than in the control group. This indicates that PRP dressing is an effective method to facilitate wound contraction in diabetic patients with foot ulcer. PRP dressing is found to be more effective, cost efcient and safe promoter of ulcer wound healing and can be used as an adjunct to saline dressings for enhanced healing of diabetic wounds.

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