Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan

2010 ◽  
Vol 145 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Yanzhuo Zhang ◽  
Zhuangzhi Zhi ◽  
Tongying Jiang ◽  
Jinghai Zhang ◽  
Zhanyou Wang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3552 ◽  
Author(s):  
Yingyu Guo ◽  
Kaijun Gou ◽  
Baixue Yang ◽  
Yumei Wang ◽  
Xueyu Pu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Water Soluble ◽  
Synthesis Process ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Anti Inflammatory ◽  
Poorly Water Soluble Drug

Large mesopores of chiral silica nanoparticles applied as drug carrier are worth studying. In this study, chiral mesoporous silica nanoparticles (CMSN) and enlarged chiral mesoporous silica nanoparticles (E-CMSN) with a particle size from 200 to 300 nm were synthesized. Fourier transform infrared spectrometer (FTIR), circular dichroism spectrum, scanning electron microscopy (SEM), transmission electron microscope (TEM), and nitrogen adsorption/desorption measurement were adopted to explore their characteristics. The results showed that the surface area, pore volume, and pore diameter of E-CMSN were higher than those of CMSN due to enlarged mesopores. Poorly water-soluble drug nimesulide (NMS) was taken as the model drug and loaded into carriers using adsorption method. After NMS was loaded into CMSN and E-CMSN, most crystalline NMS converted to amorphous phase and E-CMSN was superior. The anti-inflammatory pharmacodynamics and in vivo pharmacokinetics results were consistent with the wetting property and in vitro drug dissolution results, verifying that NMS/E-CMSN exhibited superior NMS delivery system based on its higher oral relative bioavailability and anti-inflammatory effect because its enlarge mesopores contributed to load and release more amorphous NMS. The minor variations in the synthesis process contributed to optimize the chiral nano-silica drug delivery system.

scholarly journals Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica

2018 ◽  
Vol 22 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Jyotsana R. Madan ◽  
Shronavi Patil ◽  
Dyandevi Mathure ◽  
Santosh P. Bahirat ◽  
Rajendra Awasthi
Keyword(s):  
Mesoporous Silica ◽  
Water Soluble ◽  
Dissolution Profile ◽  
Ordered Mesoporous Silica ◽  
Water Soluble Drug ◽  
Ordered Mesoporous ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug
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