Correlation of mandibular radiomorphometric indices with serum calcium and serum estradiol in pre- and post-menopausal women

Background: Postmenopausal osteoporosis is the most common bone metabolic disease associated with low bone mineral density (BMD) and osteopathic fragility fractures, which can lead to significant morbidity. The objective of this study was to investigate the relationship between serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels and bone mineral density (BMD) across the stages of menopause in Mongolian women.Methods: Two hundred sixty participants aged 50.1±4.4 years were enrolled in the study. Blood samples were obtained from each participant and analyzed using ELISA. Data were first stratified and analyzed by bone mineral density status (osteoporotic, osteopenic, and normal) and then by menopause status. Between group differences were analyzed using t-tests, and correlations were assessed using the Spearman rank order test, with Bonferonni correction. The data were analyzed using Statistical Package Statistical Software version 20.0 (SPSS Inc., Chicago, IL). Significance was set at p<0.05.Results: The mean menopausal age was 48.4±3.4, which is comparable to the Mongolian population mean menopausal age. The mean serum estradiol level in the normal BMD group was 18.3±13.1 pg/ml and 15.8±10.7 pg/ml in the osteoporotic group. The mean serum FSH in the normal BMD group was 54.5±44.1 pg/ml and 81.3±34.2 pg/ml in the osteoporotic group. The mean serum LH level in the normal BMD group was 53.1±41.2 and 75.1±26.1 pg/ml in the osteoporotic group. The mean T and Z score were lower in the osteoporotic group. FSH and LH levels significantly differed across menopause stages in that those who were post-menopausal had higher levels compared to those who were pre- or peri-menopausal. Both hormones, FSH and LH, showed weak negative correlations with BMD level, but not E2. There were significant negative correlations between FSH and Speed of Sound (SOS) (r=-0.16; p<0.01), and between osteoporosis with age (r=-0.30, p<0.05) and number of childbirths (r=-0.14 p<0.05). Discussion: Osteoporosis is a significant problem with associations to hormone levels in post-menopausal women. In our study, mean serum estradiol levels decreased with age, and the mean FSH and LH levels were higher in women of later menopausal stage. Further study is warranted to investigate the bone related studies to establish better statistical references among Mongolian women.

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Evaluation of serum calcium and serum parathyroid levels in post-menopausal women with and without oral dryness

Gerodontology ◽

10.1111/ger.12148 ◽

2014 ◽

Vol 33 (2) ◽

pp. 240-246 ◽

Cited By ~ 1

Author(s):

Balwinder Singh ◽

Shambulingappa Pallagatti ◽

Ramandeep Singh Narang ◽

Kirandeep Kaur ◽

Soheyl Sheikh ◽

...

Keyword(s):

Serum Calcium ◽

Menopausal Women ◽

Oral Dryness ◽

Post Menopausal

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Clinical Medicine: Endocrinology and Diabetes: Abnormality of Serum Lipids are Independently Associated with Increased Serum Calcium Level in the Adult Newfoundland Population

Clinical medicine Endocrinology and diabetes ◽

10.4137/cmed.s2974 ◽

2009 ◽

Vol 2 ◽

pp. CMED.S2974

Author(s):

Aaron Kennedy ◽

Sudesh Vasdev ◽

Edward Randell ◽

Ya-Gang Xie ◽

Kristian Green ◽

...

Keyword(s):

Vitamin D ◽

Total Cholesterol ◽

Serum Calcium ◽

Serum Lipids ◽

Density Lipoprotein ◽

Confounding Factors ◽

Menopausal Women ◽

25 Oh Vitamin D ◽

Positive Correlations ◽

Post Menopausal

Some epidemiological evidence shows a link between abnormality of lipid profiles and variations in serum calcium. However, it is unknown whether this association resulted from confounding factors. The present study was designed to investigate the relationship between serum lipids and calcium. Serum calcium was corrected for albumin. Major confounding factors including age, gender, medications, menopause, parathyroid hormone (PTH) and 25-OH-vitamin D status were controlled in analyses. A total of 1907 adult subjects from the province of Newfoundland and Labrador (NL), Canada participated in the study. Significant positive correlations were detected between serum total cholesterol and high density lipoprotein-cholesterol (HDL-c) with variations of serum Ca++ in both genders (p < 0.05–0.0001). Significant positive correlations were additionally detected between triglycerides (TG) and low density lipoprotein-cholesterol (LDL-c) with Ca++ in women only (p < 0.0001) in partial correlation analyses. Similar significant results were detected in both females and males not taking any medication. Analyses were performed based on menopausal status as well. Significant correlations were seen in both pre- and post-menopausal women but higher correlation coefficients were observed in pre-menopausal women as compared to post-menopausal women. Subjects with low calcium levels had the lowest concentration of total cholesterol, TG, HDL-c and LDL-c, while subjects with high calcium levels had the highest concentration of all four markers in women. The significant associations between cholesterol, TG and LDL-c and serum Ca++ remained after calcium was adjusted for 25-OH-vitamin D and PTH. Our results indicate that the abnormality of serum lipid profiles are significantly correlated with altered serum Ca++ levels independent of age, obesity status, medication, phosphorus, magnesium, 25-OH-vitamin D and PTH.

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Evaluation of Serum Calcium, Phosphorus and Progesterone in Post-Menopausal Women in Khartoum State-Sudan

International Journal of Chinese Medicine ◽

10.11648/j.ijcm.20190302.14 ◽

2019 ◽

Vol 3 (2) ◽

pp. 30

Author(s):

Rawan Alobied Saad

Keyword(s):

Serum Calcium ◽

Menopausal Women ◽

Calcium Phosphorus ◽

Post Menopausal

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Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women

Journal of Endocrinological Investigation ◽

10.1007/bf03349196 ◽

2006 ◽

Vol 29 (10) ◽

pp. 913-918 ◽

Cited By ~ 17

Author(s):

T. Yasui ◽

H. Uemura ◽

J. Tomita ◽

Y. Miyatani ◽

M. Yamada ◽

...

Keyword(s):

Undercarboxylated Osteocalcin ◽

Serum Estradiol ◽

Menopausal Women ◽

Post Menopausal

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Assessment of Nutritional Status of Menopausal Women

The Indian Journal of Nutrition and Dietetics ◽

10.21048/ijnd.2016.53.2.4299 ◽

2016 ◽

Vol 53 (2) ◽

pp. 184

Author(s):

Raut Sonali ◽

Nalwade Vijaya

Keyword(s):

Body Weight ◽

Nutritional Status ◽

Haemoglobin Level ◽

Serum Calcium ◽

Calcium Level ◽

Serum Calcium Level ◽

Mean Value ◽

The Other ◽

Menopausal Women ◽

Post Menopausal

The present study was undertaken to assess the nutritional status of menopausal women. Anthropometric measurements and biochemical parameters such as serum calcium and haemoglobin level of blood was estimated. Results indicated that mean values of body weight, BMI and hip circumference were significantly more among post menopausal women than that of pre menopausal and peri menopausal women whereas height of peri menopausal women was significantly more than that of pre menopausal and post menopausal women. On the other hand, waist hip ratio was significantly more among pre menopausal women than the other two groups of menopausal women. Mean value of serum calcium level was more in pre menopausal than that of peri menopausal and post menopausal women but significant difference was noticed among only in serum calcium level of peri menopausal and post menopausal women. More per cent of the pre menopausal women were having normal serum calcium (mg/dl) level than that of peri menopausal women and post menopausal women. Mean haemoglobin level in the blood of the menopausal women in the three stages did not differ significantly (p>0.05) and the mean value of haemoglobin of all the three groups of selected menopausal women was less than normal values. Whereas more per cent of pre menopausal women were found to be under normal haemoglobin category than that of peri menopausal and post menopausal women. On the whole the results indicated that women tend to gain body weight as they tend to reach towards the menopausal stage.

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