scholarly journals Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury

2022 ◽  
Vol 17 (7) ◽  
pp. 1505
Author(s):  
Riyi Shi ◽  
SethA Herr ◽  
Liangqin Shi ◽  
Thomas Gianaris ◽  
Yucheng Jiao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Aldehyde Dehydrogenase ◽  
Critical Role ◽  
Aldehyde Dehydrogenase 2 ◽  
Rat Spinal Cord ◽  
Cord Injury

Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury modelin vitro

2015 ◽  
Vol 42 (12) ◽  
pp. 3054-3065 ◽  
Author(s):  
Ayisha Shabbir ◽  
Elena Bianchetti ◽  
Renato Cargonja ◽  
Antonela Petrovic ◽  
Miranda Mladinic ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Motoneuron Survival ◽  
Cord Injury

Critical role of microglia in the inflammatory response after spinal injury

2015 ◽  
Vol 3 (3) ◽  
pp. 453-462
Author(s):  
Ya-Yun Shi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Inflammatory Responses ◽  
Spinal Injury ◽  
Critical Role ◽  
Cell Types ◽  
Inflammatory Factors ◽  
Cytokines And Chemokines ◽  
Cord Injury

Spinal cord injury induces a robust neuroinflammatory response that includes marked changes in the variety of endogenous CNS cell types specially microglia. In response to spinal injury, microglia undergo dramatic changes in cell morphology and promote inflammatory responses, which result in production of inflammatory factors and oxidative stress including reactive oxygen species. Further pro-inflammatory cytokines and chemokines are also rapidly up-regulated and likely contribute to microglial activation. This topic review will explore the current research on microglial responses to spinal injury and the recent progress in the pharmacologic and molecular targeting of microglia in spinal injury. Finally, we explore the argument for a positive versus negative role of microglia after spinal cord injury.

Critical Role of p38 in Spinal Cord Injury by Regulating Inflammation and Apoptosis in a Rat Model

Spine ◽  
2020 ◽  
Vol 45 (7) ◽  
pp. E355-E363 ◽  
Author(s):  
Heng-Wei Zhang ◽  
Jian-Dong Ding ◽  
Zeng-Shan Zhang ◽  
Si-shun Zhao ◽  
Kang-ying Duan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Critical Role ◽  
Cord Injury

scholarly journals Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

2012 ◽  
Vol 32 (10) ◽  
pp. 3333-3338 ◽  
Author(s):  
C. Huang ◽  
X. Han ◽  
X. Li ◽  
E. Lam ◽  
W. Peng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Connexin 43 ◽  
Critical Role ◽  
Traumatic Spinal Cord Injury ◽  
Cord Injury

scholarly journals Carbohydrate Considerations for Athletes with a Spinal Cord Injury

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2177
Author(s):  
Belinda Ruettimann ◽  
Claudio Perret ◽  
Jill A. Parnell ◽  
Joelle Leonie Flueck
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Current Knowledge ◽  
Critical Role ◽  
Nutritional Recommendations ◽  
Cord Injury ◽  
Physiological Adaptations ◽  
Key Factor ◽  
And Performance

The Paralympic movement is growing in popularity, resulting in increased numbers of athletes with a spinal cord injury (SCI) competing in various sport disciplines. Athletes with an SCI require specialized recommendations to promote health and to maximize performance, as evidenced by their metabolic and physiological adaptations. Nutrition is a key factor for optimal performance; however, scientifically supported nutritional recommendations are limited. This review summarizes the current knowledge regarding the importance of carbohydrates (CHO) for health and performance in athletes with an SCI. Factors possibly affecting CHO needs, such as muscle atrophy, reduced energy expenditure, and secondary complications are analyzed comprehensively. Furthermore, a model calculation for CHO requirements during an endurance event is provided. Along with assessing the effectiveness of CHO supplementation in the athletic population with SCI, the evaluation of their CHO intake from the available research supplies background to current practices. Finally, future directions are identified. In conclusion, the direct transfer of CHO guidelines from able-bodied (AB) athletes to athletes with an SCI does not seem to be reasonable. Based on the critical role of CHOs in exercise performance, establishing recommendations for athletes with an SCI should be the overall objective for prospective research.

scholarly journals Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Sílvia Castany ◽  
Georgia Gris ◽  
José Miguel Vela ◽  
Enrique Verdú ◽  
Pere Boadas-Vaello
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Critical Role ◽  
Central Neuropathic Pain ◽  
Cord Injury ◽  
Sigma 1

Spatiotemporal Patterns and Essential Role of MSK1 Expression After Rat Spinal Cord Injury

2013 ◽  
Vol 38 (12) ◽  
pp. 2581-2587 ◽  
Author(s):  
Zhen Li ◽  
Li Zhao ◽  
Huayun Hang ◽  
Ningxi Zhu ◽  
Bo Ning ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Essential Role ◽  
Spatiotemporal Patterns ◽  
Rat Spinal Cord ◽  
Cord Injury

Critical role of regulator of calcineurin 1 in spinal cord injury

2016 ◽  
Vol 72 (4) ◽  
pp. 605-613 ◽  
Author(s):  
Guodong Wang ◽  
Yilei Zhao ◽  
Shenpeng Liu ◽  
Jinling Jia ◽  
Tan Lu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Critical Role ◽  
Cord Injury
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