Struma Ovarii with Papillary Thyroid Carcinoma

Struma ovarii is an uncommon condition, in which thyroid tissue is the predominant or exclusive element in an ovarian teratoma. Thyroid tissue may demonstrate the same spectrum of pathological features as in the normal thyroid including benign and malignant changes. We present a case of papillary thyroid carcinoma arising in a struma ovarii of the left ovary in a 21-year-old female.

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A Hormonally Active Malignant Struma Ovarii

Case Reports in Oncological Medicine ◽

10.1155/2016/2643470 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Carolina Lara ◽

Dalia Cuenca ◽

Latife Salame ◽

Rafael Padilla-Longoria ◽

Moisés Mercado

Keyword(s):

Thyroid Hormone ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Tissue ◽

Clinical Signs ◽

Signs And Symptoms ◽

Ovarian Teratoma ◽

Struma Ovarii ◽

Papillary Thyroid ◽

Malignant Struma Ovarii

Struma ovarii is a rare monodermal variant of ovarian teratoma that contains at least 50% thyroid tissue. Less than 8% of struma ovarii cases present with clinical and biochemical evidence of thyrotoxicosis due to ectopic production of thyroid hormone and only 5% undergo malignant transformation into a papillary thyroid carcinoma. Only isolated cases of hormonally active papillary thyroid carcinoma developing within a struma ovarii have been reported in the literature. We report the case of a 36-year-old woman who presented with clinical signs and symptoms of hyperthyroidism as well as a left adnexal mass, which proved to be a thyroid hormone-producing, malignant struma ovarii.

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Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue

Molecular Carcinogenesis ◽

10.1002/mc.20193 ◽

2006 ◽

Vol 45 (8) ◽

pp. 613-626 ◽

Cited By ~ 93

Author(s):

Lewis M. Brown ◽

Steve M. Helmke ◽

Stephen W. Hunsucker ◽

Romana T. Netea-Maier ◽

Simon A. Chiang ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Protein Expression ◽

Thyroid Tissue ◽

Papillary Thyroid ◽

Normal Thyroid Tissue ◽

Normal Thyroid

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Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report

BMC Cancer ◽

10.1186/1471-2407-12-224 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 13

Author(s):

Boban Stanojevic ◽

Radan Dzodic ◽

Vladimir Saenko ◽

Zorka Milovanovic ◽

Vesna Krstevski ◽

...

Keyword(s):

Case Report ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Kras Mutation ◽

Rare Case ◽

Ovarian Teratoma ◽

Struma Ovarii ◽

Papillary Thyroid ◽

Follicular Variant ◽

Rare Case Report

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EDUCATIONAL SECTION — What should we do?Papillary thyroid carcinoma in a lymph node but normal thyroid tissue—how should we proceed?

European Journal of Surgical Oncology ◽

10.1053/ejso.1999.0766 ◽

2000 ◽

Vol 26 (2) ◽

pp. 177-180 ◽

Cited By ~ 1

Author(s):

D Flanagan ◽

P Gibb ◽

A Skene ◽

J McCutcheon ◽

M Armitage

Keyword(s):

Lymph Node ◽

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Tissue ◽

Papillary Thyroid ◽

Normal Thyroid Tissue ◽

Normal Thyroid

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A comprehensive mass spectral library for human thyroid tissues

10.1101/2021.05.27.445992 ◽

2021 ◽

Author(s):

Yaoting Sun ◽

Lu Li ◽

Weigang Ge ◽

Zhen Dong ◽

Wei Liu ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Thyroid Nodules ◽

Thyroid Tissue ◽

Follicular Adenoma ◽

Human Thyroid ◽

Papillary Thyroid ◽

Spectral Library ◽

Normal Thyroid Tissue ◽

Normal Thyroid

Thyroid nodules occur in about 60% of the population. Current diagnostic strategies, however, often fail at distinguishing malignant nodules before surgery, thus leading to unnecessary, invasive treatments. As proteins are involved in all physio/pathological processes, a proteome investigation of biopsied nodules may help correctly classify and identify malignant nodules and discover therapeutic targets. Quantitative mass spectrometry data-independent acquisition (DIA) enables highly reproducible and rapid throughput investigation of proteomes. An exhaustive spectral library of thyroid nodules is essential for DIA yet still unavailable. This study presents a comprehensive thyroid spectral library covering five types of thyroid tissue: multinodular goiter, follicular adenoma, follicular and papillary thyroid carcinoma, and normal thyroid tissue. Our library includes 925,330 transition groups, 157,548 peptide precursors, 121,960 peptides, 9941 protein groups, and 9826 proteins from proteotypic peptides. This library resource was evaluated using three papillary thyroid carcinoma samples and their corresponding adjacent normal thyroid tissue, leading to effective quantification of up to 7863 proteins from biopsy-level thyroid tissues.

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Identification of Differentially Expressed Genes Associated with Papillary Thyroid Carcinoma

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200402085832 ◽

2020 ◽

Vol 23 (6) ◽

pp. 546-553

Author(s):

Hongyuan Cui ◽

Mingwei Zhu ◽

Junhua Zhang ◽

Wenqin Li ◽

Lihui Zou ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Differentially Expressed Genes ◽

Molecular Mechanisms ◽

Cellular Proliferation ◽

Mrna Level ◽

Thyroid Tissue ◽

Differentially Expressed ◽

Thyroid Tumors ◽

Papillary Thyroid

Objective: Next-generation sequencing (NGS) was performed to identify genes that were differentially expressed between normal thyroid tissue and papillary thyroid carcinoma (PTC). Materials & Methods: Six candidate genes were selected and further confirmed with quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry in samples from 24 fresh thyroid tumors and adjacent normal tissues. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used to investigate signal transduction pathways of the differentially expressed genes. Results: In total, 1690 genes were differentially expressed between samples from patients with PTC and the adjacent normal tissue. Among these, SFRP4, ZNF90, and DCN were the top three upregulated genes, whereas KIRREL3, TRIM36, and GABBR2 were downregulated with the smallest p values. Several pathways were associated with the differentially expressed genes and involved in cellular proliferation, cell migration, and endocrine system tumor progression, which may contribute to the pathogenesis of PTC. Upregulation of SFRP4, ZNF90, and DCN at the mRNA level was further validated with RT-PCR, and DCN expression was further confirmed with immunostaining of PTC samples. Conclusion: These results provide new insights into the molecular mechanisms of PTC. Identification of differentially expressed genes should not only improve the tumor signature for thyroid tumors as a diagnostic biomarker but also reveal potential targets for thyroid tumor treatment.

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