Papillary Thyroid Carcinoma in Ectopic Thyroid Tissue Within a Suspected Cervical Paraganglioma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Marcel Ernesto Sambo Salas ◽  
Diego Muñoz Moreno ◽  
Laura Gonzalez Fernandez ◽  
Patricia Nuñez Ramos ◽  
Maria Cebollero Presmanes
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Papillary Thyroid ◽  
Ectopic Thyroid Tissue

Papillary thyroid carcinoma in a lateral neck cyst: primary of ectopic thyroid tissue versus cystic metastasis

2013 ◽  
Vol 127 (7) ◽  
pp. 724-727 ◽  
Author(s):  
J J Xu ◽  
K Kwan ◽  
K Fung
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Cystic Degeneration ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Ectopic Thyroid Tissue

AbstractObjective:To review the diagnosis of primary papillary carcinoma of ectopic thyroid tissue within branchial cleft cysts, and to discuss the diagnostic challenge of differentiating this condition from metastatic disease when an occult microcarcinoma is found in the thyroid gland.Methods:These comprise a case report and a literature review. We present the case of a 75-year-old woman with papillary thyroid carcinoma within the wall of a recurrent, 15 cm, lateral neck cyst.Results:Histological examination of the patient's thyroid gland found a 0.5 mm papillary thyroid microcarcinoma.Conclusion:Our differential diagnosis was primary papillary carcinoma arising from ectopic thyroid tissue, or metastatic cystic degeneration of a lateral lymph node. We make an argument for the former.

scholarly journals Papillary Thyroid Carcinoma as a Lateral Neck Cyst: A Cystic Metastatic Node versus an Ectopic Thyroid Tissue

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Frhana Rahmat ◽  
Ananth Kumar Marutha Muthu ◽  
Navarasi S Raja Gopal ◽  
Soh Jo Han ◽  
Azura Sharena Yahaya
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Total Thyroidectomy ◽  
Primary Tumour ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Histopathological Results

Papillary thyroid carcinoma is the most common thyroid malignancy and frequently metastasizes to regional lymph nodes. Occasionally, metastatic lymph nodes are palpable without the evidence of primary tumour. Papillary thyroid carcinoma of lateral neck cyst is a rare condition. It may arise from thyroid primary which underwent cystic degeneration or true malignant transformation of ectopic thyroid tissue. Herein, we reported two cases with preoperative diagnosis of benign lateral neck cyst but postoperative histopathological results showed primary papillary thyroid carcinoma. Ultrasonography and computed tomography of the neck in both cases showed no significant thyroid lesion. However, the patient in Case  2 was subjected for total thyroidectomy and histopathological results showed the origin of primary tumour. In conclusion, thorough investigations including total thyroidectomy are indicated in cases of papillary thyroid carcinoma of lateral neck cyst. This practice is to ensure that this type of thyroid cancer can be detected earlier because it has a very good prognosis if treated earlier.

scholarly journals Papillary Thyroid Carcinoma: Ectopic Malignancy versus Metastatic Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Yanery’s Agosto-Vargas ◽  
Madeleine Gutiérrez ◽  
José Hernán Martínez ◽  
Michelle Mangual-Garcia ◽  
Coromoto Palermo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Malignant Transformation ◽  
Thyroid Tissue ◽  
The Body ◽  
Ectopic Thyroid ◽  
Lateral Neck ◽  
Papillary Thyroid

Papillary thyroid carcinoma frequently metastasizes to regional lymph nodes. However, cervical lymph node metastasis as a sole manifestation of occult papillary thyroid carcinoma is rarely observed. Ectopic thyroid is an uncommon condition defined as the presence of thyroid tissue at a site other than pretracheal area. Approximately 1–3% of all ectopic thyroid tissue is located in the lateral neck. This entity may represent the only functional thyroid tissue in the body. Malignant transformation of ectopic thyroid is uncommon; but even rarer is the development of papillary carcinoma on it. We present a case of a 33-year-old man with an incidental lateral neck mass diagnosed after a motor vehicle accident. Total thyroidectomy and lymph node resection were completed without evidence of papillary thyroid carcinoma. Malignant transformation of heterotopic thyroid tissue was the final diagnosis. The possibility of an ectopic thyroid cancer should be considered in the differential diagnosis of a pathological mass in the neck. The uniqueness of this case strives in the rarity that the thyroid gland was free of malignancy, despite ectopic tissue being positive for thyroid carcinoma. Management strategies, including performance of total thyroidectomy, neck dissection, and treatment with radioiodine, should be based on individualized risk assessment.

scholarly journals Lingual Papillary Thyroid Carcinoma with Bilateral Neck Node Metastasis

2017 ◽  
Vol 9 (2) ◽  
pp. 68-71
Author(s):  
Sachender Pal Singh ◽  
Devendra K Jain ◽  
Subhabrata Das,
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Lingual Thyroid ◽  
Papillary Thyroid ◽  
Neck Node ◽  
Node Metastasis ◽  
Neck Node Metastasis

ABSTRACT Incidence of ectopic thyroid tissue is 1 in every 100,000 to 300,000 in general population and lingual thyroid is the most common ectopic site (90%). The number of reported neoplasms occurring in this tissue seems disproportionately small when compared with the frequency of tumor formation in the normally placed thyroid. Till now only 51 cases of lingual thyroid cancer have been reported in the literature. We are reporting a case of lingual thyroid carcinoma with bilateral cervical metastasis and absent orthotopic thyroid gland. In our case we approach the tumor via midline lip splitting with lateral mandibulotomy approach which provides us a good exposure of the entire oropharynx (tumor). We have managed the tumor according to the guidelines of differentiated thyroid cancer because of non availability of guidelines for ectopic thyroid cancer. After surgical excision of lingual thyroid and neck dissection radioiodine therapy was given. The surgical approach to a lingual thyroid cancer as well as adjuvant therapy and natural history remains to be ascertained due to the rarity of the disease. Lip splitting with lateral mandibulotomy and swing approach appears to give adequate exposure to lingual thyroid. How to cite this article Singh SP, Das S, Jain DK. Lingual Papillary Thyroid Carcinoma with Bilateral Neck Node Metastasis. World J Endoc Surg 2017;9(2):68-71.

scholarly journals Papillary Thyroid Carcinoma Occurring in Branchial Cleft Cyst: Case Report and Review of Literature

2021 ◽  
Vol 3 (2) ◽  
pp. 6-8
Author(s):  
Swei H. Tsung
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Congenital Abnormality ◽  
Thyroid Tissue ◽  
The Body ◽  
Ectopic Thyroid ◽  
Papillary Thyroid ◽  
Review Of Literature ◽  
Branchial Cleft Cyst ◽  
Branchial Cleft

Ectopic thyroid tissue is ubiquitous in the body, most frequently seen at the base of tongue, accounting for approximately 95% of reported cases. Branchial cleft cyst, a congenital abnormality, can occasionally harbor thyroid tissue inside the cyst. These ectopic thyroid tissues can develop the same disease as the orthodox thyroid gland, including the malignant diseases. Papillary thyroid carcinoma arising in the branchial cleft cyst was extremely rare, total of only 14 cases were reported in the literature. Herein, I report additional case which was discovered incidentally after surgery.

Identification of Differentially Expressed Genes Associated with Papillary Thyroid Carcinoma

2020 ◽  
Vol 23 (6) ◽  
pp. 546-553
Author(s):  
Hongyuan Cui ◽  
Mingwei Zhu ◽  
Junhua Zhang ◽  
Wenqin Li ◽  
Lihui Zou ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Differentially Expressed Genes ◽  
Molecular Mechanisms ◽  
Cellular Proliferation ◽  
Mrna Level ◽  
Thyroid Tissue ◽  
Differentially Expressed ◽  
Thyroid Tumors ◽  
Papillary Thyroid

Objective: Next-generation sequencing (NGS) was performed to identify genes that were differentially expressed between normal thyroid tissue and papillary thyroid carcinoma (PTC). Materials & Methods: Six candidate genes were selected and further confirmed with quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry in samples from 24 fresh thyroid tumors and adjacent normal tissues. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used to investigate signal transduction pathways of the differentially expressed genes. Results: In total, 1690 genes were differentially expressed between samples from patients with PTC and the adjacent normal tissue. Among these, SFRP4, ZNF90, and DCN were the top three upregulated genes, whereas KIRREL3, TRIM36, and GABBR2 were downregulated with the smallest p values. Several pathways were associated with the differentially expressed genes and involved in cellular proliferation, cell migration, and endocrine system tumor progression, which may contribute to the pathogenesis of PTC. Upregulation of SFRP4, ZNF90, and DCN at the mRNA level was further validated with RT-PCR, and DCN expression was further confirmed with immunostaining of PTC samples. Conclusion: These results provide new insights into the molecular mechanisms of PTC. Identification of differentially expressed genes should not only improve the tumor signature for thyroid tumors as a diagnostic biomarker but also reveal potential targets for thyroid tumor treatment.

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology

2019 ◽  
Vol 55 ◽  
pp. 190-195 ◽  
Author(s):  
Aleksandar Stojsavljević ◽  
Branislav Rovčanin ◽  
Đurđa Krstić ◽  
Jovana Jagodić ◽  
Slavica Borković-Mitić ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Endocrine Disruptor ◽  
Thyroid Tissue ◽  
Papillary Thyroid

scholarly journals Pre-sternal thyroid swellings: a case of rare aberrant site recurrence and review of literature

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Lovenish Bains ◽  
Sushant Bhatia ◽  
Rohit Kaushik ◽  
Sudhir Kumar Jain ◽  
Chandra Bhushan Singh ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
De Novo ◽  
Anterior Part ◽  
Thyroid Tissue ◽  
Papillary Thyroid ◽  
Thyroid Cells ◽  
Thyroid Swelling ◽  
The Right

Abstract Background Thyroid swellings enlarge caudally into the mediastinum behind the sternum. Pre-sternal swelling of thyroid origin is very rare. We present our case of pre-sternal thyroid swelling which was albeit a surprisingly rare site of papillary thyroid carcinoma recurrence and review of pre-sternal thyroid swellings reported till date. Case summary A 60 year old female presented with a painless, progressive swelling on the anterior part of the chest for the past 2 years. A 15 cm × 8 cm vertically aligned, non tender, well defined swelling was present on the pre-sternal region, with consistency ranging from soft to firm. The swelling was fixed to the underlying tissues and a fixed level IV lymph node was palpable on the right side. Ultrasonography revealed a large mass of 15 × 7 cm with multiple cystic areas. Fine needle aspiration cytology was inconclusive twice. Patient had undergone a total thyroidectomy for papillary carcinoma 10 years back. Computed tomography findings revealed a large 15 × 6.6 × 7 cm lobulated, pre-sternal, soft tissue lesion with solid & cystic components. The mass was infiltrating the right sided strap muscles and sternocleidomastoid. FNAC was inconclusive and thyroid scan could not pick up any activity in the mass. Henceforth a PET scan was done that showed increased FDG uptake by the lesion and the level IV lymph node. The patient underwent wide excision of the mass with right functional neck dissection, along with removal with both sternal head of sternocleido-mastoid, the strap muscles and the surrounding fascia. Histopathology confirmed papillary thyroid carcinoma. Patient received post-operative radioactive iodine ablation and is healthy with no recurrence up to 30 months of follow up. Discussion The mechanisms for pre-sternal thyroid swelling are not understood due to paucity of cases. The mechanisms proposed are invasion of strap muscles and cervical linea alba and tumor cells spread anterior to sternum, truly ectopic thyroid tissue, de novo carcinogenesis in the embryonal remnants like the thyro-thymic residues, sequestered thyroid tissue which grows later or migration of thyroid cells, incomplete clearance at the time of primary surgery or intraoperative seeding. Conclusion Pre-sternal region masses of thyroid origin are very rare. A proper work up, suspicion for thyroid mass and array of tests will be required to come to a provisional diagnosis. Since the masses reported in literature were primarily malignant, any such mass may be treated on lines of malignancy with radical surgery.

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