scholarly journals Effect of selenium-enriched yeast supplementation on serum thyroid-stimulating hormone and anti-thyroid peroxidase antibody levels in subclinical hypothyroidism: Randomized controlled trial

2021 ◽  
Vol 10 (1) ◽  
pp. 33
Author(s):  
Majid Mobasseri ◽  
Leila Mahmoudi ◽  
Alireza Ostadrahimi ◽  
Samira Pourmoradian ◽  
Hamid Soleimanzadeh ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Subclinical Hypothyroidism ◽  
Controlled Trial ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Randomized Controlled ◽  
Thyroid Peroxidase Antibody ◽  
Antibody Levels ◽  
Stimulating Hormone

Assessment of subclinical hypothyroidism for a clinical score and thyroid peroxidase antibody: a comparison with euthyroidism grouped by different thyroid-stimulating hormone levels

2019 ◽  
Vol 13 (3) ◽  
pp. 85-93 ◽  
Author(s):  
Darya S. Abdulateef ◽  
Taha O. Mahwi
Keyword(s):  
Subclinical Hypothyroidism ◽  
Pearson Correlation ◽  
Clinical Score ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Clinical Feature ◽  
Thyroid Peroxidase ◽  
Cross Sectional ◽  
Thyroid Peroxidase Antibody ◽  
Stimulating Hormone

Abstract Background Subclinical hypothyroidism (SCH) might have many symptoms of hypothyroidism. The controversy appears to lower the level of thyroid-stimulating hormone (TSH) and group subjects with TSH of more than 3 or even 2.5 mIU/L as SCH subjects. Objectives To assess SCH subjects both clinically using Zulewski clinical score and biochemically and to evaluate whether the euthyroid subjects with high-normal TSH (HNT) have any clinical symptom or subnormal biochemical finding. Methods A prospective cross-sectional study of 233 subjects, 67 with SCH and 166 euthyroidism, was conducted. Euthyroid subjects were divided according to the level of TSH as HNT (>2.5 mIU/L) and low-normal TSH (0.5–2.5 mIU/L). The subjects were examined for clinical feature including Zulewski clinical score and biochemical evaluations including thyroid peroxidase antibody (TPO-Ab) titer. The comparisons between groups were assessed using independent sample t test, and correlations between variables were evaluated using Pearson correlation. Results A significantly higher clinical score and higher frequencies of symptoms were found in the SCH group compared to the euthyroid group. The most frequent symptom was fatigue. Euthyroid subjects with HNT were found to have higher TPO-Ab titers than those with low-normal TSH, P < 0.05. The Zulewski clinical score was positively correlated with TSH and TPO-Ab titer but negatively correlated with the FT4 level, P < 0.05. Conclusions Zulewski clinical score is higher in SCH subjects compared to euthyroid subjects and can aid in assessing SCH subjects. A significant correlation exists between Zulewski clinical score and each of the TSH, FT4, and TPO-Ab titer levels. The frequency of TPO-Ab positivity is high in SCH. Additionally, euthyroid with higher TSH levels has higher level of TPO-Ab titer but not higher clinical score.

scholarly journals RANDOMIZED CONTROLLED TRIAL COMPARING MORNING VERSUS NIGHT ADMINISTRATION OF LEVOTHYROXINE IN OLDER PERSONS

2021 ◽  
Author(s):  
Karina Giassi ◽  
Renato Gorga Bandeira de Mello ◽  
Bruna Cambrussi de Lima ◽  
Gabriela Stahl ◽  
Raquel Almeida de Oliveira ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Older Persons ◽  
Controlled Trial ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Randomized Controlled ◽  
Baseline Visit ◽  
Morning Administration ◽  
Tsh Levels

OBJECTIVE: To evaluate the effectiveness of levothyroxine administration strategies in the treatment of hypothyroidism in older persons in a tertiary outpatient clinic. METHODS: A randomized controlled trial of older persons with a diagnosis of primary hypothyroidism who had been receiving levothyroxine for at least 6 months with a stable dose in the last 3 months. Patients were randomly assigned to one of two administration strategies: morning (1 hour before breakfast) or night (1 hour after the last meal). In a period ≥ 12 weeks, patients were instructed to cross over between strategies. Laboratory tests for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were performed at visit 0 (baseline), visit 1 (period ≥ 12 weeks), and visit 2 (completion — period ≥ 24 weeks); a standardized questionnaire was also applied. Preliminary analyses of the period before crossover are presented. RESULTS: The preliminary sample consisted of 98 patients, with a mean age of 71.26 (SD 7.12) years; 83.67% were women. Fifty-three patients started with the morning strategy and 45 with the night strategy, and one patient did not return for reassessment. Median TSH levels ranged from 2.74 (IQR 1.06–4.19) at baseline to 2.77 (IQR 0.75–4.41) after a 12-week follow-up in the morning group, and from 2.36 (IQR 1.48–4.85) to 2.28 (IQR 1.69–3.56) in the night group. Mean FT4 levels ranged from 1.44 (SD 0.39) to 1.42 (SD 0.36) in the morning group, and from 1.35 (SD 0.27) to 1.37 (SD 0.32) in the night group. CONCLUSIONS: The administration of levothyroxine at night was as effective as morning administration at controlling primary hypothyroidism in older persons. Therefore, this can be considered an alternative dosage strategy for the treatment of this condition.

scholarly journals Restoration of euthyroidism accelerates bone turnover in patients with subclinical hypothyroidism: a randomized controlled trial

2004 ◽  
Vol 15 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Christian Meier ◽  
M�ller Beat ◽  
Merih Guglielmetti ◽  
Mirjam Christ-Crain ◽  
Jean-Jacques Staub ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bone Turnover ◽  
Subclinical Hypothyroidism ◽  
Controlled Trial ◽  
Randomized Controlled
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