scholarly journals Mammary analog secretory carcinoma parotid gland: Case report of a recently described tumor with review of literature

2017 ◽  
Vol 03 (02) ◽  
pp. 139-143
Author(s):  
Vandana L. Gaopande ◽  
Maithili M. Kulkarni ◽  
Siddhi G. S. Khandeparkar ◽  
Avinash R. Joshi
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Malignant Neoplasm ◽  
Low Grade ◽  
Review Of Literature ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Parotid Swelling ◽  
Oncocytic Variant ◽  
Cytological Evaluation ◽  
Mammary Analog Secretory Carcinoma

AbstractMammary analog secretory carcinoma (MASC) is a low-grade malignant tumor of salivary glands. It is so named because of its cytohistopahological, immunohistological, and cytogenetic resemblance to secretory carcinoma of the breast. Since the first description of this tumor in 2010, about 70 cases have been reported in literature. We report a case of this recently described tumor in a 21-year-old female. The radiological diagnosis of her parotid swelling was pleomorphic adenoma. The cytological evaluation was suggestive of oncocytoma. The histopathology showed a low-grade malignant neoplasm and the differential included papillary variant of acinic cell carcinoma, oncocytic variant of mucoepidermoid carcinoma, and MASC. Immunohistochemistry confirmed the diagnosis of MASC. We have included a brief review of literature.

scholarly journals Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features

2019 ◽  
Vol 12 (4) ◽  
pp. e224612
Author(s):  
Nicholas B Abt ◽  
Matthew E Lawler ◽  
Joseph Zacharias ◽  
Edward T Lahey
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Malignant Neoplasm ◽  
Inflammatory Lesion ◽  
Advancement Flap ◽  
Careful Examination ◽  
Iliac Crest Bone Graft ◽  
Odontogenic Cysts ◽  
Low Grade ◽  
Malignant Tumours ◽  
Second Molar

Mucoepidermoid carcinoma (MEC) can be rarely found as a primarily intraosseous lesion and mistaken for other intraosseous or odontogenic pathology. A 65-year-old man had a poorly defined radiolucency distal to the left mandibular second molar root. Periapical radiographs demonstrated a minor radiolucency from 2.5 years prior. An oral and maxillofacial surgeon felt the radiolucency represented periodontal disease, extracting tooth #18. The differential diagnosis of mixed radiolucent/radio-opaque mandibular lesions includes: (1) fibro-osseous lesion, (2) odontogenic and non-odontogenic cyst, (3) infection and inflammatory lesion, or (4) benign or malignant neoplasm (odontogenic, non-odontogenic, or metastatic). Histological analysis revealed low-grade MEC. A composite resection was performed with a 1 cm margin from first molar to ascending ramus. A buccal fat pad advancement flap covered the defect with an iliac crest bone graft placed later for a resulting osseous defect. Careful examination and diagnostic work-up for odontogenic cysts should be provided as they may harbour malignant tumours.

scholarly journals Secretory Carcinoma of the Breast With Multiple Distant Metastases in Brain and Unfavorable Prognosis: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hongping Tang ◽  
Lihua Zhong ◽  
Hongbing Jiang ◽  
Gui’e Xie
Keyword(s):  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Distant Metastases ◽  
Left Breast ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mri Scan ◽  
Carcinoma Of The Breast ◽  
Favorable Prognosis ◽  
Axillary Lymphadenectomy

Abstract Background: Secretory carcinoma of the breast is one of the rarest entities accounting for less than 0.15% of all infiltrating breast carcinomas. It has characteristic histopathological and molecular features and more favorable prognosis. In this case report, we describe a local advanced secretory carcinoma of the breast with chemo-resisted for neoadjuvant chemotherapy and unfavorable prognosis.Case Presentation: A hard, painless and palpably bossed mass about 12 cm in diameter occupied most of the left breast of a 39-year-old woman and fixation to the overlying skin. Breast ultrasonography and magnetic resonance imaging (MRI) scan gave the same grading as BI-RADS IV. A needle biopsy was performed and pathological diagnosis was secretory carcinoma. Neoadjuvant chemotherapy (NAC) was then performed, after which ultrasonography and MRI scan revealed the tumor was partial response for EC therapy while progressive disease after the DC therapy. The tumor showed chemo-resisted for neoadjuvant chemotherapy. Left breast mastectomy and axillary lymphadenectomy were subsequently performed. Tumor cells were triple-negative and positive for S-100 and periodic acid-Schiff (PAS) staining. Fluorescence in-situ hybridization (FISH) analysis indicated the fusion arrangement of ETV6-NTRK3 gene. The patient underwent multiple distant metastases in brain, and died of these metastases 19 months after initial diagnosis.Conclusion: Secretory carcinomas of breast have been described as a low-grade histologic subtype with a favorable prognosis. This case showed chemo-resisted for neoadjuvant chemotherapy, multiple distant metastases, and final an unfavorable prognosis. Further research is needed to better understanding of its behavior and treatment of this rare tumor.

scholarly journals Histological surprise, mammary analogue secretory carcinoma of parotid gland

2021 ◽  
Vol 8 (12) ◽  
pp. 3731
Author(s):  
Iram T. Pasha ◽  
Akhila K. ◽  
Ravikumar V. ◽  
Sandeep Kumar
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Carcinoma Of The Breast ◽  
Mammary Analogue Secretory Carcinoma ◽  
Male Preponderance ◽  
Slow Growing

A recent described entity, mammary analogue secretary carcinoma (MASC) in 2010 by Skalova et al whose morphological and immunohistochemical features are similar in secretory carcinoma of the breast and salivary gland. This is a low-grade carcinoma which presents as a firm, slow-growing, circumscribed lesion with male preponderance. We present a case report of MASC.

Low-grade adenosquamous carcinoma of the breast: A case report and review of literature

2014 ◽  
Vol 3 (5) ◽  
pp. 408
Author(s):  
Yasmeen Khatib ◽  
RichaD Patel ◽  
Arsala Mulla ◽  
Candes Francis
Keyword(s):  
Case Report ◽  
Adenosquamous Carcinoma ◽  
Low Grade ◽  
Review Of Literature ◽  
Carcinoma Of The Breast

scholarly journals Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

2014 ◽  
Vol 99 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Vilvapathy Senguttuvan Karthikeyan ◽  
Sarath Chandra Sistla ◽  
Ramachandran Srinivasan ◽  
Debdatta Basu ◽  
Lakshmi C. Panicker ◽  
...  
Keyword(s):  
Malignant Neoplasm ◽  
Second Primary ◽  
Malignant Neoplasms ◽  
Rare Occurrence ◽  
Review Of Literature ◽  
Second Primary Malignancy ◽  
Carcinoma Of The Breast ◽  
Primary Malignancy ◽  
Multiple Primary ◽  
Second Primary Malignancies

Abstract Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.

1. Mucoepidermoid carcinoma of the breast – a case report and review of literature

Pathology ◽  
2010 ◽  
Vol 42 ◽  
pp. S81
Author(s):  
Roel Cayari ◽  
Lloyd McGuire ◽  
Stephen Weinstein ◽  
Sunil Lakhani
Keyword(s):  
Case Report ◽  
Mucoepidermoid Carcinoma ◽  
Review Of Literature ◽  
Carcinoma Of The Breast

scholarly journals Histopathological Analysis of Neoplastic and Non Neoplastic Lesions of Salivary Gland – A Retrospective Study in a Tertiary Care Hospital

2021 ◽  
Vol 8 (05) ◽  
pp. 236-240
Author(s):  
Sheela K.M ◽  
Priya V.S. ◽  
Lali K. Rajan ◽  
Ashida M. Krishnan
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Care Hospital ◽  
Neoplastic Lesions

BACKGROUND Salivary gland lesions constitute less than 1 % of tumours and about 4 % of all epithelial neoplasms of head and neck region. These comprise of a wide variety of benign, malignant and non-neoplastic lesions which exhibits a difference in histological behaviour. There are no reliable criteria to differentiate on clinical grounds the benign from malignant ones. So morphological evaluation is necessary. We aim to study the frequency of various salivary gland lesions in sialoadenectomy specimens and categorise them into neoplastic and nonneoplastic lesions. METHODS It is a record based retrospective 5-year study carried out in the Government Medical College, Thiruvananthapuram, Kerala, from January 2014 to December 2018. RESULTS In this study a total of 329 histopathologically proven cases of salivary gland lesions were included. Neoplastic lesions and non-neoplastic lesions constituted 78.42 % and 21.58 % respectively. Pleomorphic adenoma was the most common neoplasm (50.54 %) trailed by Warthin’s tumour (9.73 %). Most common malignant neoplasm encountered in our study was mucoepidermoid carcinoma (9.73 %) among which low grade tumours showed predominance. We observed significantly higher incidence of benign and malignant lesions in the 5 th to 6th decade while non neoplastic lesions were seen more in the 4th to 5th decade. Average age of the patients with salivary gland tumours was 46.12  SD 15.57. Majority of cases of salivary gland lesions in our study were from parotid gland (75.68 %) followed by submandibular gland 24.01 %. CONCLUSIONS Pleomorphic adenoma was the most common benign tumour in our study and mucoepidermoid carcinoma the most common malignant tumour. Neoplastic lesions showed a predominance over non neoplastic lesions. Histopathological examination is the mainstay for diagnosis and clinical management. KEYWORDS Histopathology, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

Sign in / Sign up

Export Citation Format

Share Document