scholarly journals Histopathological Analysis of Neoplastic and Non Neoplastic Lesions of Salivary Gland – A Retrospective Study in a Tertiary Care Hospital

2021 ◽  
Vol 8 (05) ◽  
pp. 236-240
Author(s):  
Sheela K.M ◽  
Priya V.S. ◽  
Lali K. Rajan ◽  
Ashida M. Krishnan
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Care Hospital ◽  
Neoplastic Lesions

BACKGROUND Salivary gland lesions constitute less than 1 % of tumours and about 4 % of all epithelial neoplasms of head and neck region. These comprise of a wide variety of benign, malignant and non-neoplastic lesions which exhibits a difference in histological behaviour. There are no reliable criteria to differentiate on clinical grounds the benign from malignant ones. So morphological evaluation is necessary. We aim to study the frequency of various salivary gland lesions in sialoadenectomy specimens and categorise them into neoplastic and nonneoplastic lesions. METHODS It is a record based retrospective 5-year study carried out in the Government Medical College, Thiruvananthapuram, Kerala, from January 2014 to December 2018. RESULTS In this study a total of 329 histopathologically proven cases of salivary gland lesions were included. Neoplastic lesions and non-neoplastic lesions constituted 78.42 % and 21.58 % respectively. Pleomorphic adenoma was the most common neoplasm (50.54 %) trailed by Warthin’s tumour (9.73 %). Most common malignant neoplasm encountered in our study was mucoepidermoid carcinoma (9.73 %) among which low grade tumours showed predominance. We observed significantly higher incidence of benign and malignant lesions in the 5 th to 6th decade while non neoplastic lesions were seen more in the 4th to 5th decade. Average age of the patients with salivary gland tumours was 46.12  SD 15.57. Majority of cases of salivary gland lesions in our study were from parotid gland (75.68 %) followed by submandibular gland 24.01 %. CONCLUSIONS Pleomorphic adenoma was the most common benign tumour in our study and mucoepidermoid carcinoma the most common malignant tumour. Neoplastic lesions showed a predominance over non neoplastic lesions. Histopathological examination is the mainstay for diagnosis and clinical management. KEYWORDS Histopathology, Pleomorphic Adenoma, Mucoepidermoid Carcinoma

scholarly journals A clinical study of the incidence of salivary gland tumors in a tertiary care teaching hospital

2019 ◽  
Vol 6 (6) ◽  
pp. 2110
Author(s):  
Sathish Babu N. ◽  
Naveen H. Mahadev ◽  
Kumar G. V.
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Critical Role ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Salivary Gland Tumour ◽  
Major Salivary Gland ◽  
Salivary Gland Tumours ◽  
Gland Tumour

Background: The salivary gland system of the upper aero digestive tract plays a critical role in the functions of digestion, respiration, communication, and overall homeostasis. The Salivary gland swellings can be broadly classified into inflammatory, non-inflammatory and neoplastic swellings like calculi, benign tumours such has pleomorphic adenoma, oncocytoma, Warthin's tumour, malignant tumors which include-adenocarcinoma, adenoid cystic carcinoma, undifferentiated carcinoma.Methods: The present cross-sectional study was conducted at the Department of general surgery, Sri Siddhartha Medical College over a period of 2 years from August 2016 to July 2018.  All major salivary gland neoplastic swellings confirmed by FNAC were included in this study.Results: In our study 23 patients had major salivary gland tumours out of that 19 patients had parotid and 4 had submandibular major salivary gland tumour. In our study out 23 cases of salivary tumours 19 cases were benign and 4 cases were malignant, out of 19 cases of parotid tumours, 15 (78.94%) cases were seen in superficial lobe and 4 (21.06%) were in deep lobe, out of 23 salivary gland tumours, 19 (82.6%) cases were pleomorphic adenoma 3(13.05%) cases were mucoepidermoid carcinoma and one case (4.35%) was acinic cell carcinoma.Conclusions: Parotid gland was the most common site of origin of both benign and malignant tumours, Pleomorphic adenoma was the most common benign salivary gland tumour and mucoepidermoid carcinoma was the most frequent malignant neoplasm.

scholarly journals Histopathological spectrum of salivary gland lesions - in a tertiary care centre

2020 ◽  
Vol 9 (1) ◽  
pp. 97
Author(s):  
Gomathi Srinivasan ◽  
Francis Asir Joseph J. ◽  
Shanmugam Kaliyaperumal ◽  
Arunalatha Ponnaiah
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Benign Tumors ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Malignant Neoplasms ◽  
Morphological Aspect ◽  
Chronic Sialadenitis

ABSTRACT Background: Histopathology is the most important means in diagnosis of salivary gland lesions. The objective of this study is, to study occurrence of salivary lesions during a period of one year from January 2019 to December 2019, to study age, sex and site distribution of various salivary gland lesions, to study histo-morphological aspect of these lesions.Methods: Surgically resected salivary gland specimens received at Department of Pathology, Government Stanley Medical College, Chennai were subjected to histopathological examination. Specimens were fixed in 10% neutral buffered formalin, processed, embedded, sections cut and stained with hematoxylin and eosin stain.Results: There were a total of 30 salivary gland specimens. Out of thirty, 25 were neoplastic and 5 were non-neoplastic. Pleomorphic adenoma was the commonest of all benign tumors. Mucoepidermoid carcinoma was the most common malignant tumor. Among the 21 benign tumors, 16 cases of pleomorphic adenoma and a case each of myoepithelioma, benign metastasising pleomorphic adenoma, basal cell adenoma, warthins tumor and schwannoma were found. Among the 4 malignant tumors, 2 cases of mucoepidermoid carcinoma, a case of carcinoma ex pleomorphic adenoma and a case of myoepithelial carcinoma were found. Among the 5 non neoplastic lesions a case each of chronic sialadenitis, Sjogren’s syndrome, inflammatory myofibroblastioc tumor, parotid abscess and lymphoepithelial cyst were found.Conclusions: The diagnosis of salivary gland lesions by histopathological examination is the most important method in diagnosis and differentiating benign and malignant lesions and to predict prognosis by typing, staging and grading of malignant neoplasms.

Surgico-pathological analysis of testicular lesions

2021 ◽  
Vol 6 (4) ◽  
pp. 250-254
Author(s):  
Surabhi Arun Vidhale ◽  
Pragati Upasham
Keyword(s):  
Histopathological Examination ◽  
Picric Acid ◽  
Tertiary Care ◽  
Primary Objective ◽  
Histopathological Analysis ◽  
Care Hospital ◽  
Age Group ◽  
Presenting Symptoms ◽  
Neoplastic Lesions ◽  
Testicular Lesions

The primary objective of our study was to identify the different types of histopathological lesions of testes and epididymis occurring in patients admitted in a tertiary care hospital, the objective was also to analyze the spectrum of testicular lesions, our aim was to evaluate the prevalence of testicular malignancies and characterize the tumor based on their histo-morphological features. This was a prospective study of 2 years (October 2018 to October 2020) aggregating a total of 52 cases. The surgical specimens were referred to the pathology department for histopathological analysis. Adetailed preoperative history of every case with regards to age, presenting symptoms, and signs along with personal history were obtained.Also, relevant investigations like serum tumor markers and Ultrasonography findings were analyzed. Postoperatively, the tissue was sent to the histopathology department was studied by proper fixation, gross examination, adequate sampling, and paraffin sections of the same.10% formalin was used to fix the specimen. Some resources suggest the use of Bouin solution for the fixation of testis biopsy specimens. However, the picric acid in the Bouin solution presents challenges for safe handling and disposal due to its explosive potential.Hence, given the available resources in our laboratory setting, formalin was the preferred choice of fixative. We ensured that the specimens came in adequate amount of formalin from the OT with correct labeling.We excluded the autolyzed specimens. The data was noted and quantitative analysis was done.The study was further compared with other previously reported studies. 52 cases were studied and majority of the cases were reported in the age group of 31-40yrs. 65.4% cases were non neoplastic, with testicular torsion being the commonest lesion. Amongthe 23.1% neoplastic cases that were reported, mixed germ cell tumor was the commonest (75%). Non neoplastic lesions are more common than neoplastic lesions. Torsion testis was the commonest indication for orchidectomy in younger age group. Despite newer techniques in imaging and tumor marker assays the diagnosis of testicular lesions is primarily dependent upon histopathological examination.

scholarly journals Histopathological Scenario of Testicular Lesions with Few Uncommon Entities – 3 Years Study in a Tertiary Care Hospital

2021 ◽  
Vol 8 (9) ◽  
pp. 467-470
Author(s):  
Padma Madana ◽  
Vijayasree Mandava ◽  
Neelima Govada ◽  
Padmavathi Devi Chaganti ◽  
Zafrul Haque Mohammed ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Common Finding ◽  
Care Hospital ◽  
Malignant Tumours ◽  
Cell Hyperplasia ◽  
Equal Distribution ◽  
Splenogonadal Fusion ◽  
Inflammatory Conditions ◽  
Neoplastic Lesions

BACKGROUND The incidence of testicular malignancy has been increasing in men, orchidectomy is necessary for the removal of neoplastic lesions or in patients with chronic inflammatory conditions resistant to treatment. We wanted to evaluate the various histopathological patterns of lesions in testis. METHODS A retrospective study of 86 orchidectomy specimens over a period of three years with age wise distribution from March 2017 to February 2020 was done in the Department of Pathology, Guntur Medical College, Guntur. Histopathological slides stained with haematoxylin and eosin were retrieved and reviewed. Immunohistochemistry was done in two cases. RESULTS Of the 86 cases, 78 (90.7 %) cases were non neoplastic and 8 (9.3 %) cases were neoplastic. Youngest age in non-neoplastic group was four days and in neoplastic group was 18 years. The oldest age was 82 years in the non-neoplastic lesions and 60 years in the neoplastic lesions. Non neoplastic lesions were common in the 3 rd decade. In malignant lesions, highest number of cases was seen in the 6 th decade and equal distribution was observed in 3rd and 5th decade. Unilateral involvement was common than bilateral involvement. Out of all non-neoplastic lesions, undescended testis 20 (25.64 %) cases was the common finding followed by non-specific epididymo orchitis 19 (24.36 %) cases, abscess 14 (17.95 %) cases, torsion infarction 13 (16.67 %) cases, Leydig cell hyperplasia 4 (5.13 %) cases, 3 (3.85 %) cases each of tuberculous epididymo orchitis and granulomatous epididymo orchitis. 1 (1.28 %) case each of rare entities like vanishing testis and splenogonadal fusion were also found. Among the neoplastic lesions, all 8 cases were malignant tumours. Out of these malignant tumours, mixed germ cell tumours were seen in 3 (37.5 %) cases followed by seminomas 2 (25 %) cases, post pubertal teratoma 1 (12.5 %) case, non-Hodgkin’s lymphoma (NHL) 1 (12.5 %) case and primitive neuroectodermal tumour (PNET) 1 (12.5 %) case. CONCLUSIONS Histopathological examination on routine haematoxylin and eosin (H&E) stained sections primarily differentiate non neoplastic lesions from neoplastic group and benign tumours from malignant tumours as the treatment modality varies. Immunohistochemistry (IHC) is useful in the diagnosis of poorly differentiated small round cell tumours. KEYWORDS Orchidectomy Specimens, Neoplastic and Non-Neoplastic Lesions

scholarly journals Clinicopathological study of lesions of nasal cavity and paranasal sinuses- A two year study

2021 ◽  
Vol 6 (4) ◽  
pp. 259-266
Author(s):  
Ankita Sunil Chaudhari ◽  
Shivaji Dadarao Birare
Keyword(s):  
Nasal Cavity ◽  
Clinical Evaluation ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Cost Effective ◽  
Descriptive Study ◽  
Care Hospital ◽  
Diagnostic Dilemma ◽  
Neoplastic Lesions

Sinonasal masses are common in the ENT Outpatient Department. The incidence being 1-4% of population. The symptoms and signs frequently overlap, hence, a diagnostic dilemma exists. The aim of this study was to study the occurrence of various lesions, the age, site and sex wise distribution in a tertiary care hospital of Maharashtra over the period of two years. The study aims to examine the occurrence of various lesions in nasal cavity and paranasal sinuses, to determine the age, sex and site wise incidence of different benign and malignant lesions of nasal cavity and paranasal sinuses and to correlate the clinical and histopathological findings. Descriptive Study A descriptive study was carried out in the Department of Pathology at Tertiary Health Care among patients with clinically diagnosed nasal and paranasal sinus lesions attending the OPD of ENT during a period of 2 years. The specimens were grossly examined; fixed and routine microscopic staining was done. Interpretation was done using colour of the nuclei and the specimens were classified as neoplastic and non-neoplastic lesions. The data was statistical analysed. Mean, Median, Mode The most common clinical presentation was nasal obstruction 97 (93.26%), rhinorrhoea 73 (70.19%) and facial pain 24 (23%). 1: Mean age for the lesions to occur was years with the range 21-30 years (20.92%); 2: Non-neoplastic lesions 82 (79.6%) were more common than neoplastic lesions; 3: Simple nasal polyp 74 (90.23%), hemangiomas (50%) and squamous cell carcinoma (50%) were most common. The study concludes that complete clinical, radiological and histopathological correlation helps us to categorize these sino-nasal lesions into various non-neoplastic and neoplastic types. But final histopathological examination provides a confirmatory diagnosis, as a significant number of cases may be missed on clinical evaluation alone.The clinical features of non-neoplastic and neoplastic nasal and paranasal sinuses lesions may be indistinguishable from each other leading to delay in proper diagnosis and treatment. Histopathological examination is a reliable, cost effective diagnostic tool for accurate diagnosis and management of such lesions, as a significant number of cases may be missed on clinical evaluation alone.

scholarly journals Histopathological spectrum and outcome of surgery for salivary gland tumors presented in tertiary care hospital of Pakistan.

2021 ◽  
Vol 28 (10) ◽  
pp. 1418-1421
Author(s):  
Ahmed Siddique Ammar ◽  
Rizwan Khalid ◽  
Syed Asghar Naqi ◽  
Shehrbano Khattak ◽  
Farwa Inayat ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Benign Tumor ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Salivary Gland Tumors ◽  
Care Hospital ◽  
Outcome Of Surgery ◽  
Malignant Salivary Gland Tumors

Objective: This study is aimed to know the histopathological spectrum and outcome of surgery for salivary gland tumors presented in a tertiary care hospital of Pakistan. Study Design: Retrospective study. Setting: Tertiary Care Hospital of Pakistan. Period: July 2018 to June 2020. Material & Methods: After approval from Institutional Review Board. Total 73 patients were selected with preoperative diagnosis of salivary gland tumors with consecutive non probability sampling. All surgical procedures were done by specialist general surgeons who had experience of more than 10 years of head and neck surgery. Results: Male to female ratio was 2:1 with mean age of patients was 46 years. Among males 29 (59.1%) were benign salivary gland tumors while 20 (40.81%) were malignant salivary gland tumors. Among females 13 (54.16%) were benign and 11 (45.83%) were malignant salivary gland tumors Most common benign tumor was pleomorphic adenoma 32 (43.8%) while mucoepidermoid carcinoma was most common malignant tumor 17 (23.28%). Only 9 (12.32%) patients experienced nerve paresis. Conclusion: Male preponderance, a relatively younger age at presentation and single predominant benign tumor (pleomorphic adenoma) were the significant findings. Majority of them were found in parotid gland and found to be benign in nature. Majority of them were found in parotid gland and found to be benign in nature. Although fine needle aspiration cytology and magnetic resonance imaging provide some useful information about the nature of tumor but most of them will acquire a surgical excision in order to find the definitive diagnosis.

scholarly journals Parotid gland tumors an evaluation at Tertiary Care Hospital.

2020 ◽  
Vol 27 (01) ◽  
pp. 80-83
Author(s):  
Agha Taj Mohammed ◽  
Sajda Khuhawar ◽  
Bibi Gulsama ◽  
Salman Shams
Keyword(s):  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Malignant Tumor ◽  
Mucoepidermoid Carcinoma ◽  
Benign Tumor ◽  
Tertiary Care ◽  
Maxillofacial Surgery ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Parotid Gland Tumors

Objectives: To evaluate epidemiological pattern, early diagnostic tool and histological type of parotid gland tumors. Study Design: Prospective cross sectional study. Setting: Department of Oral & Maxillofacial Surgery& General Surgery Liaquat University hospital Hyderabad. Period: From 2013 to 2017. Material & Methods: Study contains 67 patients of parotid tumors after initial diagnosis. These patients were first diagnosed by FNAC (Fine needle aspiration cytology) along with CT scan & MRI where required. Final diagnosis was established after histopathological diagnosis of tumor. Results: Males were predominantly involved in both tumor patterns. Most common age group was 5th decade in both benign and malignant tumors. FNAC has diagnostic sensitivity of almost 90-97%. Out of 67, 51 tumors were benign and 16 were malignant. Pleomorphic adenoma was the most common benign tumor while mucoepidermoid carcinoma was found as most received malignant tumor. Conclusion: Pleomorphic adenoma is most commonly found benign tumor and mucoepidermoid carcinoma is found more in numbers as malignant tumor.

scholarly journals Clinicopathological profile of sinonasal masses-a tertiary care centre study in rural India

2020 ◽  
Vol 6 (10) ◽  
pp. 1821
Author(s):  
Vidya Rokade ◽  
Kiran J. Shinde ◽  
Girishkumar R. More
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Rural India ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Radiological Investigation ◽  
Male Predominance ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions

<p><strong>Background:</strong> A variety of mass lesions occur within the paranasal sinus (PNS) and nasal cavity and thus it becomes mandatory for otorhinolaryngologist to elicit detailed history and thorough examination before reaching a final diagnosis. This is retrospective study of all sinonasal masses who were undergone surgical management in the institute of rural India and so in the environment.</p><p><strong>Methods:</strong> This is a retrospective observational study of 70 patients with sinonasal masses treated at a rural tertiary care hospital in rural western Maharashtra from period of Jan 2016 to May 2018. History, clinical assessment and histopathological examination (HPE) was done in all cases as per hospital record supplemented by radiological investigation as per requirement. The patients were grouped as per their histopathological diagnosis as non-neoplastic/inflammatory and neoplastic.</p><p><strong>Results:</strong> A total of 70 patients were analysed age ranging (11-70 years). Majority of the patients were in the age groups 21-40 years (47%). There were 43 (61%) male and 27 (39%) female with M:F ratio 1.6:1. On HPE, 50 (71%) cases were non neoplastic/inflammatory and 20 (29%) cases were neoplastic lesions. HPE revealed that 50 (71%) cases were non neoplastic and 20 (29%) cases were neoplastic lesions.</p><p><strong>Conclusions:</strong> Sinonasal masses have various differential diagnoses. They are fairly common with male predominance. Benign conditions show a peak during 2<sup>nd</sup> to 4<sup>th</sup> decade of life while malignancy increasing with the age after 4th decade. In non-neoplastic lesion, Allergic nasal polyp is the commonest histological pattern seen while in malignant lesions squamous cell carcinoma is noted with 100% male predominance.</p><p> </p>

scholarly journals Low Grade Central Mucoepidermoid Carcinoma

2015 ◽  
Vol 5 (1) ◽  
pp. 31-34
Author(s):  
Kartik Poonja ◽  
Janaki Subramanian Iyer ◽  
Leela Poonja
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Male Patient ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Malignant Neoplasm ◽  
Low Grade ◽  
Gland Tumor ◽  
Malignant Salivary Gland Tumor ◽  
Central Mucoepidermoid Carcinoma

ABSTRACT Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, comprising about 15% of all salivary gland tumors and 30% of all salivary malignancies. Most of the MEC arise in the parotid gland. Rarely, it originates in the mandible and maxilla as an intraosseous variant, referred to as ‘central mucoepidermoid carcinoma’ or ‘intraosseous mucoepidermoid carcinoma’. Central mucoepidermoid carcinomas (CMECs) are extremely rare, but well-known entity, comprising 2 to 3% of all MECs reported. Histopathologically, this malignant neoplasm is characterized by mucous, intermediate and epidermoid cells. In this report, we present a case of a male patient diagnosed as low grade CMEC. How to cite this article Iyer JS, Poonja K, Pathak J, Patel S, Poonja L. Low Grade Central Mucoepidermoid Carcinoma. J Contemp Dent 2015;5(1):31-34.

Sign in / Sign up

Export Citation Format

Share Document