This chapter provides a summary of a landmark study in hernia surgery. In terms of recurrence, pain, and complications, is laparoscopic inguinal hernia repair with mesh better than traditional open mesh repair? Starting with that question, it describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving possible inguinal hernia repair.