Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis

Introduction Oral Submucous fibrosis (OSMF) occurs in young adults, who are in the habit of chewing tobacco mixed with areca nut and its various commercially available preparations. The disease results in progressive inability to open the mouth due to the submucosal fibrosis initiated by chronic inflammation affecting mainly oral mucosa. Authors undertook the present study to correlate the clinical features of OSMF to histopathological features and to find out aetiopathological factors of this condition. Materials and Methods A total of 123 clinically diagnosed OSMF patients, in the age range of 17 to 70 years were studied. Mouth opening was measured using a scale and was recorded in millimeters. Incisional biopsy was taken from the representative areas in the oral cavity. The patients were graded clinically and histopathologically and results were analyzed and discussed. Result Most of the patients were in the age group of 20-30 years (37.4%) with male predominance. The duration of either tobacco or areca nut chewing ranged from 1 to 35 yrs. Most patients had these habits for 6-19 yrs. Majority (55.3% & 54.5%) of the patients belonged to grade-2 (clinical grading) and intermediate grade (HPE grading) respectively. The HPE grading showed significant and direct association with duration of ill habits. The HPE grading showed significant and direct association with clinical grading (χ2=204.08, p<0.001). Discussion The HPE grading showed significant and direct association with duration of ill habits and also with clinical findings of restriction of mouth opening and inter incisal distance. The HPE findings showed significant and direct association with clinical grading i.e. when the clinical grading increases, the histopathological grading also increases. Conclusion OSMF is a disease with a high incidence. It also carries a significant risk of transformation to oral cancer. As no effective medical and surgical treatment is available for this condition; it is desirable to diagnose OSMF at early stages.

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Oral submucous fibrosis: A quantitative assessment of serum malondialdehyde, superoxide dismutase and correlation with clinical staging

Journal of Oral and Maxillofacial Pathology ◽

10.4103/jomfp.jomfp_214_16 ◽

2017 ◽

Vol 21 (1) ◽

pp. 41

Author(s):

Ratnakar Bale ◽

KiranKumar Kattappagari ◽

Desai Vidya ◽

Sivapradobh Vuddandi ◽

Charani Gummalla ◽

...

Keyword(s):

Superoxide Dismutase ◽

Quantitative Assessment ◽

Oral Submucous Fibrosis ◽

Clinical Staging ◽

Submucous Fibrosis

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Commentary on Clinical Staging and Histological Grading In Oral Submucous Fibrosis

Journal of Medical & Surgical Pathology ◽

10.4172/2472-4971.1000114 ◽

2016 ◽

Vol 01 (02) ◽

Author(s):

Dominic Augustine ◽

Roopa S Rao ◽

Manish ◽

Shankargouda Patil ◽

Tina Elizabeth Jacob

Keyword(s):

Oral Submucous Fibrosis ◽

Clinical Staging ◽

Histological Grading ◽

Submucous Fibrosis

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Clinical Staging of Oral Submucous Fibrosis : A Review

International Journal of Oral-Medical Sciences ◽

10.5466/ijoms.10.216 ◽

2011 ◽

Vol 10 (3) ◽

pp. 216-219 ◽

Cited By ~ 1

Author(s):

Shivakumar. G.C. ◽

Sahana. S.

Keyword(s):

Oral Submucous Fibrosis ◽

Clinical Staging ◽

Submucous Fibrosis

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A comparative study on efficacy of different treatment modalities of oral submucous fibrosis evaluated by clinical staging in population of Southern Rajasthan

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.139263 ◽

2015 ◽

Vol 11 (1) ◽

pp. 113 ◽

Cited By ~ 5

Author(s):

Saurabh Goel ◽

Junaid Ahmed

Keyword(s):

Comparative Study ◽

Oral Submucous Fibrosis ◽

Clinical Staging ◽

Treatment Modalities ◽

Submucous Fibrosis

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Oral Submucous Fibrosis – A Clinicopathological Correlation

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i58a34155 ◽

2021 ◽

pp. 589-594

Author(s):

R. Sudarshan

Keyword(s):

Early Stage ◽

Oral Submucous Fibrosis ◽

Correlation Study ◽

Clinical Staging ◽

P Value ◽

Histopathological Correlation ◽

Potentially Malignant ◽

Submucous Fibrosis ◽

Group 2 ◽

Group 1

Objective: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa and collagen metabolic disorder caused by betel nut use. Diagnosis of this condition can be made clinically, but ascertaining its malignant transformation histopathology is mandatory. So, the correlation between the clinical and histopathology was conducted. Materials and Methods: The correlation study was conducted on 20 OSMF patients. Clinical diagnosis with histopathological confirmation was based on the standard approach. Study structure included gender, duration, frequency, and quid placement correlated with clinical and histopathological staging. Results: The current study has included most of the subjects being males and was below 25 years. Habit duration, frequency, and quid placement were correlated with clinical and histopathological staging and were directly related. Six subjects of (30%) Group 1 cases associated with 3 (42.9%) in the histologically early stage of the disease. Further, 14 (70%) cases in Group 2 clinical staging correlated with 8 (88.9%) cases in moderately advanced histological staging. Conclusion: The clinical and histopathological correlation was not obtained in the present study. The negative p-value could be because of certain factors like biopsy site selection and decreased study subjects. However, factors like frequency and quid keeping had a positive histopathological correlation.

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