A comparative study of therapeutic efficacy of intralesional measles, mumps, and rubella vaccine and intralesional Vitamin D3 in the treatment of recurrent warts

2021 ◽  
Vol 25 (1) ◽  
pp. 14
Author(s):  
Manjunath Kadnur ◽  
ShishiraR Jartarkar ◽  
P Mamatha ◽  
SwayamS Mishra ◽  
B Spoorthy

2020 ◽  
Vol 37 (5) ◽  
pp. 853-859
Author(s):  
Alpana Mohta ◽  
Ramesh Kumar Kushwaha ◽  
Umesh Gautam ◽  
Pritee Sharma ◽  
Asha Nyati ◽  
...  


Author(s):  
Shrikant . ◽  
R.D. Mehta ◽  
B.C. Ghiya

Background: Verruca is one of the common dermatopathologies which has multiple therapeutic options but with variable success rates, refractory cases and high recurrence rates. Nowadays, treatment with intralesional injections has gained recognition due to its effectiveness in clearing verrucae. These act by stimulating the cell-mediated immunity. Out of scores of options available for intralesional therapeutics, Vitamin D3 appears to be more promising but least evaluated. Therefore, we planned to evaluate the efficacy of intralesional Vitamin D3 in various types of cutaneous verrucae. Simultaneously the results were compared with intralesional bleomycin, also. Methods: A total of 200 patients of cutaneous verrucae with varying size and duration were included in the experimental randomized comparative study. We divided them into two groups. Group A, comprising of 100 patients, received 0.2-0.5 ml intralesional Vitamin D3 (600,000 IU, 15mg/ml) and Group B, also of hundred subjects, received intralesional Bleomycin (1 mg/ml) into the base of verrucae. A maximum of 5 verrucae were injected per session at 3 weeks interval until resolution or for a maximum of 4 sessions. Patients were followed up for 6 months after the last injection to assess the clearance status and detect any recurrence. Results: In Group A (Vitamin D3), 'Complete response', 'Partial response' and 'No response' were observed in 85.07%, 6.74% and 8.17% respectively after 4 sessions. Recurrence rate was 0.81% after 6 months. In Group B (Bleomycin), 'Complete response', 'Partial response' and 'No response' were found in 77.99%, 10.47% and 11.53% in the series. Recurrence rate was 1.71%, comparatively higher in group B. Conclusion: The efficacy of intralesional Vitamin D3 was found significantly higher as compared to intralesional Bleomycin in the treatment of cutaneous verrucae with less recurrence rates. Vitamin D3 has an additional advantage of cost-effective treatment over Bleomycin. We purpose its use, as a primary mode of treatment in various types of cutaneous verrucae. Keywords: Bleomycin, Vitamin D3, Verrucae.





CellBio ◽  
2013 ◽  
Vol 02 (03) ◽  
pp. 97-104
Author(s):  
Shreyasee Chakraborty ◽  
Bibiana Sandoval-Bernal ◽  
James Kumi-Diaka


2015 ◽  
Vol 4 (4) ◽  
pp. 19-23
Author(s):  
S R Adhikari

Electroconvulsive therapy (ECT) is one of the less used somatic treatments in mood disorders, especially depressive phase. ECT use has importance during acute bipolar episode when patient extremely violent, suicidal and extreme psychomotor retardation. The aim of this study was to know about socio-demographic profile and therapeutic efficacy of the use of ECT in mood disorders. Methods: This is a prospective comparative study between patients who received ECT and who did not. Psychopathology was evaluated using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS) between the groups at admission, at discharge, at 1st month, at 6th month and at 12th month. Modified ECT was performed using general anesthetic agent. Results: Twenty five patients received ECT as compared to 32 patients who were non-receivers. There was significant decrease in HDRS in ECT receiver as compared to non-receivers in patients with depression (both unipolar and bipolar) at discharge, 1st month, and 12th month; in YMRS in patient with mania at discharge, 1st month and at 12th month.Discussion: There was significant improvement in overall psychopathology and psycho-social status of patients who received ECT as compared to non-receivers. The improvement was shown by decrement in scores in HDRS and YMRS at the time of discharge, 1st month, 6th month and 1st year which were statistically significant.DOI: http://dx.doi.org/10.3126/jcmc.v4i4.11958



2019 ◽  
Author(s):  
Mohammed Abbas Baghdadi ◽  
Mohammed Aslam ◽  
Jawwad Ahmad ◽  
Shakir Idris ◽  
Bassem Refaat


1998 ◽  
Vol 8 ◽  
pp. S161
Author(s):  
G.P. Panteleeva ◽  
L.I. Abramova ◽  
A.N. Korenev


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