A clinical trial to evaluate the efficacy of 5% potassium nitrate gel on sensitivity during ultrasonic scaling

SUMMARY Objectives: This randomized clinical trial tested the three-month desensitizing effect of two protocols using nano-hydroxyapatite formulations compared with Pro-Argin and fluoride varnish. Methods: Twenty-eight subjects with 137 teeth presenting dentin exposure with a minimal hypersensitivity of four on the visual analog scale (VAS) took part of this study. The subjects were randomly assigned to four groups: Desensibilize Nano-P paste (20% hydroxyapatite [HAP], potassium nitrate, and sodium fluoride [NaF]; 9000 ppm fluoride [F]); Desensibilize Nano-P associated with experimental home-care pastes (10% HA, potassium nitrate, and NaF; 900 ppm F); Pro-Relief professional paste (8% arginine with Pro-Argin technology) associated with home-care toothpaste (8% arginine, sodium monofluorophosphate, 1450 ppm F); and Duraphat professional varnish (NaF varnish, 22,600 ppm F). The professional treatments were performed in weekly appointments over three weeks. The home-care products were used continuously for three months. A VAS was used to assess the tooth sensitivity response after standardized evaporative stimulus at baseline and after one month and three months. The baseline score was deducted from the final score, and the means were analyzed using nested analysis of variance, while the comparison between times was performed by a general linear model (p<0.05). Results: At the first month all treatments were effective, but there were no significant differences among them (p=0.94). At the third month, despite the fact that NaF varnish had the lowest effect in reducing hypersensitivity, no significant difference was found among the treatments (p=0.09). Only Pro-Relief increased its effect over time (p=0.049). Conclusions: Nano-hydroxyapatite formulations (with or without home->care product association) were as effective as the other treatments in reducing dentin hypersensitivity over three months.

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Clinical Effects of Desensitizing Prefilled Disposable Trays in In-office Bleaching: A Randomized Single-blind Clinical Trial

Operative Dentistry ◽

10.2341/18-149-c ◽

2020 ◽

Vol 45 (1) ◽

pp. E1-E10

Author(s):

LM Martins ◽

LA Lima e Souza ◽

E Sutil ◽

LM da Silva ◽

JOS Silva ◽

...

Keyword(s):

Clinical Trial ◽

Color Change ◽

Absolute Risk ◽

Potassium Nitrate ◽

Clinical Effects ◽

Bleaching Agent ◽

Chi Square ◽

Peroxide Bleaching ◽

The Absolute ◽

Single Blind

SUMMARY Objectives: This study aimed to evaluate the desensitizing effect of a prefilled disposable tray containing potassium nitrate and fluoride on the self-reported tooth sensitivity (TS) and the bleaching efficacy of 40% hydrogen peroxide bleaching agent used for in-office bleaching in comparison with potassium nitrate and fluoride gel applied in a conventional-delivered tray system in an equivalence clinical trial. Methods and Materials: Seventy-eight patients, with a right maxillary canine darker than A3, were selected for this single-blind (evaluators), randomized clinical trial. Teeth were bleached in two sessions with a one-week interval in between. Before in-office bleaching, the prefilled disposable tray or conventional tray containing potassium nitrate and fluoride was used for 15 minutes. Subsequently, the bleaching agent was applied in two 20-minute applications (per the manufacturer's directions) in each session. The color change was evaluated by subjective (Vita Classical and Vita Bleachedguide) and objective (Easyshade Advance Spectrophotometer) methods at baseline and 30 days after the first bleaching session. TS was recorded for up to 48 hours using a 0-10 visual analog scale. The absolute risk was evaluated by chi-square test, while the intensity of TS was evaluated by McNemar test (α=0.05). Color change in shade guide units and ΔE was analyzed by Student t-test for independent samples (α=0.05). Results: Significant whitening was observed in both groups after 30 days of clinical evaluation. The use of different methods of desensitizer in a tray did not influence the absolute risk and intensity of TS (p>0.05), although a tendency of lower risk of TS with the prefilled disposable tray containing potassium nitrate and fluoride was observed. Conclusion: The use of a prefilled disposable tray containing potassium nitrate and fluoride before the application of the in-office bleaching product did not affect the whitening degree and decreased self-reported TS when compared with a conventional-delivered tray system.

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Comparison of Clinical Efficacy of a Dentifrice Containing Calcium Sodium Phosphosilicate to a Dentifrice Containing Potassium Nitrate and to a Placebo on Dentinal Hypersensitivity: A Randomized Clinical Trial

Journal of Periodontology ◽

10.1902/jop.2010.100056 ◽

2010 ◽

Vol 81 (8) ◽

pp. 1167-1173 ◽

Cited By ~ 68

Author(s):

AR Pradeep ◽

Anuj Sharma

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Clinical Efficacy ◽

Potassium Nitrate ◽

Dentinal Hypersensitivity

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Is the use of a potassium nitrate dentifrice effective in reducing tooth sensitivity related to in‐office bleaching? A randomized triple‐blind clinical trial

Journal of Esthetic and Restorative Dentistry ◽

10.1111/jerd.12826 ◽

2021 ◽

Author(s):

María Gracia Ortega‐Moncayo ◽

Paulina Aliaga‐Sancho ◽

Camilo Pulido ◽

Mario Felipe Gutierrez ◽

Estuardo Rodriguez‐Salazar ◽

...

Keyword(s):

Clinical Trial ◽

Potassium Nitrate ◽

Tooth Sensitivity

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Clinical and Radiographic Assessments of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as Pulpotomy Biomaterials in Immature Mandibular First Permanent Molars: A Randomized Clinical Trial

Journal of Endodontics ◽

10.1016/j.joen.2021.08.009 ◽

2021 ◽

Author(s):

Mohammed Ibrahim Ahmed ◽

Ghada El Hilaly Mohamed Eid ◽

Hamdy Adly Youssef

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Mineral Trioxide Aggregate ◽

Potassium Nitrate ◽

Permanent Molars ◽

First Permanent Molars

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Comparison between 940 nm Laser Diode and Topical 5 % Potassium Nitrate for Tooth Desensitization. Randomized Controlled Clinical trial

Universitas Odontologica ◽

10.11144/javeriana.uo37-79.cldt ◽

2018 ◽

Vol 37 (79) ◽

Author(s):

Oscar Tocarruncho ◽

Xiomara Alexandra Espitia Robayo ◽

Edgar Ibáñez Pinilla ◽

Néstor Raúl Ríos-Osorio

Keyword(s):

Clinical Trial ◽

Laser Diode ◽

Therapy Group ◽

Potassium Nitrate ◽

Periodontal Therapy ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled ◽

Actual Application ◽

Higher Sensitivity

Purpose: To compare the effectiveness of two dental desensitization therapies, 940 nm laser diode and potassium nitrate, in patients with dental hypersensitivity (DH) symptoms. Methods: This randomized clinical trial included 30 patients who initially underwent basic periodontal therapy and presented gingival recessions Class I and II (Miller 1985) with symptoms of DH. Subjects were randomly assigned into two groups. The first group (n = 15) received laser 940 nm application for 90 seconds on the surface of the recession and were given a tube of glycerin to be applied daily in order to avoid generating bias. Patients in the second group (n = 15) were exposed to inactive laser simulating the actual application of the laser, and they were given a desensitizing gel containing 0.5 g of potassium nitrate to be applied twice daily during 14 days. Controls were carried out at 15 minutes, 8 days, 15 days, and 4 weeks. Data obtained were filled out in an Excel table. For comparison between groups the Mann Whitney U and t student tests were used (p=0.05). Results: All patients involve in the study experienced reduction in DH (p<0.01) and differences between the two interventions performed. Conclusions: Laser and nitrate therapies were effective to manage DH after basic periodontal therapy. However, a statistically significant higher sensitivity reduction was observed in laser therapy group.

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Comparison of Traditional and Low Sensitivity Whiteners

Operative Dentistry ◽

10.2341/07-134 ◽

2008 ◽

Vol 33 (4) ◽

pp. 379-385 ◽

Cited By ~ 35

Author(s):

W. D. Browning ◽

D. C. Chan ◽

M. L. Myers ◽

W. W. Brackett ◽

M. G. Brackett ◽

...

Keyword(s):

Clinical Trial ◽

Clinical Practice ◽

Clinical Relevance ◽

Potassium Nitrate ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo ◽

Low Levels ◽

Low Sensitivity ◽

Postoperative Sensitivity

Clinical Relevance The results of this double-blind, placebo-controlled clinical trial have direct relevance to clinical practice and provide evidence that the addition of low levels of potassium nitrate and/or potassium nitrate and fluoride significantly reduce postoperative sensitivity relative to products that do not contain either agent.

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Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial

Journal Of Clinical Periodontology ◽

10.1034/j.1600-051x.2003.20077.x ◽

2003 ◽

Vol 30 (4) ◽

pp. 315-320 ◽

Cited By ~ 32

Author(s):

Susana Cuesta Frechoso ◽

Manuel Menéndez ◽

Cristina Guisasola ◽

Ignacio Arregui ◽

José M Tejerina ◽

...

Keyword(s):

Clinical Trial ◽

Randomised Clinical Trial ◽

Potassium Nitrate ◽

Dentine Hypersensitivity

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A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice

The Journal of Contemporary Dental Practice ◽

10.5005/jcdp-10-2-1 ◽

2009 ◽

Vol 10 (2) ◽

pp. 1-9 ◽

Cited By ~ 5

Author(s):

Matthew L. Barker ◽

Philip G. Bellamy ◽

Nichelle Khera ◽

Trevor N. Day ◽

Andrew J. Mussett

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Sodium Fluoride ◽

Potassium Nitrate ◽

Dental Erosion ◽

Positive Control ◽

Sodium Hexametaphosphate ◽

Double Blind ◽

Plaque Area ◽

Stannous Fluoride

Abstract Aim To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF2/SHMP with 1450 ppm F). Methods and Materials Twenty-five subjects were randomized to a two-period, two-treatment, double blind crossover sequence using NaF/KNO3 (Sensodyne® ProNamel™ dentifrice) and SnF2/SHMP (blend-a-med®* EXPERT GUMS PROTECTION dentifrice). Each treatment was conducted with a standard manual toothbrush (Oral-B® P35 Indicator). Digital plaque image analysis (DPIA) was used on three consecutive days to evaluate: (a) overnight plaque formation (A.M. pre-brushing); (b) following 40 seconds of brushing with the test product (A.M. post-brushing); and (c) mid-afternoon (P.M.). Images were analysed using an objective computer algorithm to calculate the total area of visible plaque. A four-day washout period was instituted for the crossover phase. Results All 25 subjects completed the study. The SnF2/SHMP positive control dentifrice provided statistically significantly lower levels of plaque area coverage versus the NaF/KNO3 test dentifrice at each timepoint. For the SnF2/SHMP dentifrice, plaque coverage was 23.0% lower (p<0.0001) at A.M. pre-brushing, 17.3% (p=0.0163) lower at A.M. post-brushing, and 22.6% (p= 0.0004) lower at the P.M. measure relative to the NaF/KNO3 dentifrice. Conclusion The SnF2/SHMP dentifrice (blend-a-med® EXPERT GUMS PROTECTION) inhibits plaque regrowth both overnight and during the day to a significantly greater degree than the NaF/KNO3 dentifrice (Sensodyne® ProNamel™). Clinical Significance Dentists recommending an effective home use dentifrice for patients experiencing dentinal hypersensitivity and/or dental erosion may previously have needed to compromise on other key benefits, such as plaque control. blend-a-med® EXPERT GUMS PROTECTION is a dentifrice when integrated into an oral hygiene routine can provide a proven treatment for hypersensitivity, dental erosion, and a reduction in the regrowth of plaque. Citation Bellamy PG, Khera N, Day TN, Barker ML, Mussett AJ. A Randomized Clinical Trial to Compare Plaque Inhibition of a Sodium Fluoride/Potassium Nitrate Dentifrice versus a Stabilized Stannous Fluoride/ Sodium Hexametaphosphate Dentifrice. J Contemp Dent Pract 2009 March; (10)2:001-009. * Also branded Crest® and Ipana, depending on the country.

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