An atypical presentation of plasma cell gingivitis with generalized skin lesions

We report a clinical case of a rare variant of pemphigus - pemphigus herpetiformis - which combines the clinical features of dermatitis herpetiformis with the immunological findings of pemphigus. Due to its atypical presentation, it is frequently misdiagnosed as dermatitis herpetiformis. It is basically characterized by the herpetiform pattern of skin lesions, severe pruritus and by the presence of eosinophilic spongiosis confirmed on histopathology. We call attention to the excellent response to dapsone.

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Metastatic plasma cell leukemia to the skin: a case report with review of the literature

Dermatology Reports ◽

10.4081/dr.2021.9099 ◽

2021 ◽

Author(s):

Elena Pezzolo ◽

Deborah Saraggi ◽

Luigi Naldi

Keyword(s):

Plasma Cell ◽

Plasma Cells ◽

Clinical Presentation ◽

Clinical Course ◽

Skin Lesions ◽

Plasma Cell Leukemia ◽

Cell Leukemia ◽

Leukemia Cutis ◽

Aggressive Clinical Course ◽

New Skin

Plasma cell leukemia (PCL) is a rare variant of leukemia with an aggressive clinical course and a poor prognosis. The cutaneous involvement in PCL is very rare either at clinical presentation of leukemia, namely “leukemia cutis”, or in the metastatic PCL to the skin. We present a case of eruptive multiple cutaneous nodules in a 56-year-old man with metastatic PCL. Histologically, a diffuse dermal and subcutaneous infiltration of ovoid cells with amphophilic cytoplasm and eccentrically located nucleus consistent with plasmacytoid morphology was observed. Neoplastic cells showed strong immunoexpression for CD138 and CD38 consistent with plasma cells phenotype, and loss of expression of CD56. Kappa light chain restriction similar to the phenotype of his PCL was demonstrated. We suggest that the evaluation of new skin lesions in leukemic patients should include a histopathologic examination to establish the diagnosis as soon as possible and a correct management of the disease.

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Vulvar myiasis: Atypical Presentation as carcinoma vulva

10.1055/s-0039-1685367 ◽

2016 ◽

Author(s):

Savita Rani Singhal ◽

Esha Gupta ◽

S. K. Singhal ◽

Keyword(s):

Skin Lesions ◽

Clinical Findings ◽

Temperate Climate ◽

Vulvar Carcinoma ◽

Atypical Presentation ◽

Parasitic Infestation ◽

Close Inspection ◽

Cutaneous Myiasis ◽

Warm Temperate

Myiasis is a parasitic infestation, rarely seen in the vulval region with more cases being reported in tropical, subtropical and warm temperate climate. Cutaneous myiasis can be misdiagnosed as cellulitis, leishmaniasis, sebaceous cysts, staphylococcal boil, insect bite or skin abscess. Knowledge of the characteristic clinical findings and the close inspection of skin lesions are key to diagnosing myiasis. We report a case of vulval maggots which was misdiagnosed as vulvar carcinoma and caused undue anxiety to the patient.

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A rare case of plasma cell osteomyelitis with atypical presentation

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20195822 ◽

2019 ◽

Vol 6 (1) ◽

pp. 227

Author(s):

Mallikarjuna Reddy Rowdur Meghalamane ◽

Alla Vasanth Kumar ◽

Gandham Satya Avinash ◽

Yellapu Surendra

Keyword(s):

Plasma Cell ◽

Rare Case ◽

Chronic Osteomyelitis ◽

Histopathological Examination ◽

Rare Condition ◽

Left Knee ◽

Long Bone ◽

Atypical Presentation ◽

Open Biopsy ◽

X Ray

<p class="abstract">Plasma cell osteomyelitis is an uncommon type of localized chronic osteomyelitis which is characterized by the absence of typical clinical features of infection. It usually affects the metaphysis of long bones and presents as dense thickening of bone without sequestrum formation. We present an atypical case of plasma cell osteomyelitis with a lesion in the diaphysis of long bone and sequestrum formation<em>.</em> A 23 year old male patient came to our OPD with complaint of pain in mid-thigh radiating to the left knee since 2 months. X-ray showed radiolucencies in the medulla of middle third of shaft of femur along with a linear sequestrum suggestive of chronic osteomyelitis. An open biopsy was performed and surgical curettage was done. Histopathological examination was consistent with plasma cell osteomyelitis. Chronic plasma cell osteomyelitis is a rare condition with nonspecific findings and an unclear cause. Histopathology is the definitive tool for obtaining a diagnosis. Knowledge of this condition and proper management can give a better outcome, at the same time avoiding unnecessary investigations and procedures.</p>

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Plasma Cell Dyscrasias of the Lung: An Atypical Presentation of Non-IgM Lymphoplasmacytic Lymphoma

CHEST Journal ◽

10.1016/j.chest.2016.08.1205 ◽

2016 ◽

Vol 150 (4) ◽

pp. 1098A

Author(s):

Emilie Wang ◽

Angel Martin ◽

Nishan Tchekmedyian ◽

Gopi Prithviraj

Keyword(s):

Plasma Cell ◽

Atypical Presentation ◽

Lymphoplasmacytic Lymphoma ◽

Plasma Cell Dyscrasias

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Fulminant hepatitis in a patient with secondary syphilis

International Journal of STD & AIDS ◽

10.1177/0956462418785257 ◽

2018 ◽

Vol 29 (13) ◽

pp. 1348-1350

Author(s):

Ana Beatriz Affonso da Costa ◽

Bruna Fornazari ◽

Fernanda Perin Maia da Silva ◽

Gibran A Frandoloso ◽

Giovanni L Breda

Keyword(s):

Acute Hepatitis ◽

Fulminant Hepatitis ◽

Unusual Case ◽

Clinical Manifestations ◽

Skin Lesions ◽

Secondary Syphilis ◽

Clinical Suspicion ◽

Diagnosis And Treatment ◽

Atypical Presentation ◽

High Clinical Suspicion

Despite the increasing incidence of syphilis and due to its wide variety of clinical manifestations, syphilis remains an under-diagnosed condition. We report an unusual case of secondary syphilis presenting with acute hepatitis and skin lesions, confirmed based on positive treponemal and non-treponemal assays. Despite adequate diagnosis and treatment, the patient developed fulminant hepatitis and brain death. This atypical presentation emphasizes the importance of high clinical suspicion in recognizing syphilis as an etiology for unexplained acute hepatitis, allowing early diagnosis and treatment and possibly avoiding severe complications such as fulminant hepatic failure.

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Cutaneous Plasmacytosis with Perineural Involvement

Case Reports in Dermatological Medicine ◽

10.1155/2014/840845 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Elizabeth A. Brezinski ◽

Maxwell A. Fung ◽

Nasim Fazel

Keyword(s):

Plasma Cell ◽

Plasma Cells ◽

Skin Lesions ◽

Unknown Etiology ◽

Cell Infiltrate ◽

Lambda Light Chain ◽

Chemotherapeutic Regimen ◽

History Of ◽

Systemic Symptoms

Importance. Cutaneous and systemic plasmacytosis are rare conditions of unknown etiology with characteristic red-brown skin lesions and a mature polyclonal plasma cell infiltrate within the dermis. Perineural plasma cell infiltrates may be a histologic clue to the diagnosis of cutaneous plasmacytosis.Observations. Our patient had a five-year history of persistent reddish-brown plaques on the neck and trunk without systemic symptoms. Histologic examination showed dermal perivascular and perineural plasma cells with excess lambda light chain expression. Due to decreased quality of life caused by his skin lesions, he was placed on a chemotherapeutic regimen with bortezomib.Conclusions and Relevance. The patient was diagnosed with cutaneous plasmacytosis based on classic histopathology results with a recently characterized pattern of perineural involvement. Bortezomib therapy was initiated to manage his skin eruption, which has not been previously described as a treatment for this chronic condition.

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