Inverted ileal loop prolapse through patent vitellointestinal duct

ABSTRACT The viaB locus contains genes for the biosynthesis and export of the Vi capsular antigen of Salmonella enterica serotype Typhi. Wild-type serotype Typhi induces less CXC chemokine production in tissue culture models than does an isogenic viaB mutant. Here we investigated the in vivo relevance of these observations by determining whether the presence of the viaB region prevents inflammation in two animal models of gastroenteritis. Unlike S. enterica serotype Typhimurium, serotype Typhi or a serotype Typhi viaB mutant did not elicit marked inflammatory changes in the streptomycin-pretreated mouse model. In contrast, infection of bovine ligated ileal loops with a serotype Typhi viaB mutant resulted in more fluid accumulation and higher expression of the chemokine growth-related oncogene alpha (GROα) and interleukin-17 (IL-17) than did infection with the serotype Typhi wild type. There was a marked upregulation of IL-17 expression in both the bovine ligated ileal loop model and the streptomycin-pretreated mouse model, suggesting that this cytokine is an important component of the inflammatory response to infection with Salmonella serotypes. Introduction of the cloned viaB region into serotype Typhimurium resulted in a significant reduction of GROα and IL-17 expression and in reduced fluid secretion. Our data support the idea that the viaB region plays a role in reducing intestinal inflammation in vivo.

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Metabolic Alterations Following Diversion of Urine from Colon to Ileal Loop

The Journal of Urology ◽

10.1016/s0022-5347(17)66296-7 ◽

1958 ◽

Vol 79 (3) ◽

pp. 463-470 ◽

Cited By ~ 5

Author(s):

Lester Persky ◽

Stanley Levey ◽

William E. Abbott

Keyword(s):

Ileal Loop ◽

Metabolic Alterations

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Effects of Clostridium perfringens Beta-Toxin on the Rabbit Small Intestine and Colon

Infection and Immunity ◽

10.1128/iai.00547-08 ◽

2008 ◽

Vol 76 (10) ◽

pp. 4396-4404 ◽

Cited By ~ 54

Author(s):

Jorge E. Vidal ◽

Bruce A. McClane ◽

Juliann Saputo ◽

Jaquelyn Parker ◽

Francisco A. Uzal

Keyword(s):

Small Intestine ◽

Clostridium Perfringens ◽

Time Course ◽

Defense Mechanism ◽

Intestinal Damage ◽

Loop Model ◽

Type B ◽

Ileal Loop ◽

Type C ◽

Beta Toxin

ABSTRACT Clostridium perfringens type B and type C isolates, which produce beta-toxin (CPB), cause fatal diseases originating in the intestines of humans or livestock. Our previous studies demonstrated that CPB is necessary for type C isolate CN3685 to cause bloody necrotic enteritis in a rabbit ileal loop model and also showed that purified CPB, in the presence of trypsin inhibitor (TI), can reproduce type C pathology in rabbit ileal loops. We report here a more complete characterization of the effects of purified CPB in the rabbit small and large intestines. One microgram of purified CPB, in the presence of TI, was found to be sufficient to cause significant accumulation of hemorrhagic luminal fluid in duodenal, jejunal, or ileal loops treated for 6 h with purified CPB, while no damage was observed in corresponding loops receiving CPB (no TI) or TI alone. In contrast to the CPB sensitivity of the small intestine, the colon was not affected by 6 h of treatment with even 90 μg of purified CPB whether or not TI was present. Time course studies showed that purified CPB begins to induce small intestinal damage within 1 h, at which time the duodenum is less damaged than the jejunum or ileum. These observations help to explain why type B and C infections primarily involve the small intestine, establish CPB as a very potent and fast-acting toxin in the small intestines, and confirm a key role for intestinal trypsin as an innate intestinal defense mechanism against CPB-producing C. perfringens isolates.

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Investigation of attaching and effacing activity of ruminant eae-positive Escherichia coli using rabbit and lamb ligated ileal loop assays

Veterinary Record ◽

10.1136/vr.154.18.565 ◽

2004 ◽

Vol 154 (18) ◽

pp. 565-568 ◽

Cited By ~ 1

Author(s):

R. de la Fuente ◽

S. Garcia ◽

J. A. Ruiz-Santa-Quiteria ◽

D. Cid ◽

J. A. Orden

Keyword(s):

Escherichia Coli ◽

Ileal Loop

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What is the onset mechanism of internal hernia after vertebral body fracture? A case of internal hernia secondary to traumatic vertebral fracture

BMJ Case Reports ◽

10.1136/bcr-2020-241005 ◽

2021 ◽

Vol 14 (9) ◽

pp. e241005

Author(s):

Akiyo Matsumoto ◽

Takahiko Akao ◽

Hiroshi Matsumoto ◽

Naoki Kobayashi ◽

Makoto Kamiya

Keyword(s):

Internal Hernia ◽

Histopathological Examination ◽

Lumbar Vertebra ◽

The Body ◽

Neurological Deficits ◽

Disc Space ◽

Ileal Loop ◽

Body Fracture ◽

Enhanced Ct

A 67-year-old man who had been pinned between a basket crane and a tree complained of severe pain in his lower back and a decreased appetite. Laparotomy after decompressing the gastrointestinal tract revealed incarceration of an ileal loop within a fractured third lumbar vertebra. The damaged bowel was resected, and an end-to-end anastomosis was performed. Once the patient’s condition had stabilised, posterior lumbar fixation was performed. There were no abdominal complications or lower limb neurological deficits during the follow-up period. Enhanced CT and MRI had been helpful in making the diagnoses. Histopathological examination revealed the aetiology of the traumatic incarceration: the intestine had been pinched as the disc space closed, and the body attempted to return to its original state by exerting countertraction.

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