Implant survival in patients with neuropsychiatric, neurocognitive, and neurodegenerative disorders: A meta-analysis

AbstractSeveral authors have suggested that implants can be placed simultaneously with onlay bone grafts without affecting outcomes. Therefore, the purpose of this study was to answer the following clinical questions: (1) What are the outcomes of implants placed simultaneously with autogenous onlay bone grafts? And (2) is there a difference in outcomes between simultaneous vs delayed placement of implants with autogenous onlay bone grafts? Databases of PubMed, Embase, and Google Scholar were searched up to 15 November 2020. Data on implant survival was extracted from all the included studies (single arm and comparative) to calculate point estimates with 95% confidence intervals (CI) and pooled using the DerSimonian–Laird meta-analysis model. We also compared implant survival rates between the simultaneous and delayed placement of implants with data from comparative studies. Nineteen studies were included. Five of them compared simultaneous and delayed placement of implants. Dividing the studies based on follow-up duration, the pooled survival of implant placed simultaneously with onlay grafts after <2.5 years of follow-up was 93.1% (95% CI 82.6 to 97.4%) and after 2.5–5 years was 86% (95% CI 78.6 to 91.1%). Implant survival was found to be 85.8% (95% CI 79.6 to 90.3%) with iliac crest grafts and 95.7% (95% CI 83.9 to 93.0%) with intra-oral grafts. Our results indicated no statistically significant difference in implant survival between simultaneous and delayed placement (OR 0.43, 95% 0.07, 2.49, I2=59.04%). Data on implant success and bone loss were limited. Data indicates that implants placed simultaneously with autogenous onlay grafts have a survival rate of 93.1% and 86% after a follow-up of <2.5 years and 2.5–5years respectively. A limited number of studies indicate no significant difference in implant survival between the simultaneous and delayed placement of implants with onlay bone grafts. There is a need for randomized controlled trials comparing simultaneous and delayed implant placement to provide robust evidence.

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Mini-Implant-Retained Overdentures for the Rehabilitation of Completely Edentulous Maxillae: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18084377 ◽

2021 ◽

Vol 18 (8) ◽

pp. 4377

Author(s):

Serena Vi ◽

Damon Pham ◽

Yu Yian Marina Du ◽

Himanshu Arora ◽

Santosh Kumar Tadakamadla

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Survival Rate ◽

Data Extraction ◽

Meta Analysis ◽

Empirical Studies ◽

Implant Survival ◽

Patient Reported ◽

Full Text Review

Purpose: Mini-dental implants (MDIs) have been used to support and retain overdentures, providing patients with a less invasive placement procedure. Although lucrative, the use of MDIs to retain a maxillary overdenture is still not an established treatment modality. This systematic review aims to answer the question: Do mini-implant-retained maxillary overdentures provide a satisfactory treatment outcome for complete edentulism? Methods: A systematic search for relevant articles was conducted to include articles published until April 2021 in the following electronic databases: CINAHL, Cochrane, EMBASE, PubMed, and Web of Science. All empirical studies evaluating the biological, survival, or patient-reported outcomes after placing mini-implant-retained overdentures in maxilla were considered for inclusion. The risk of bias was assessed by utilizing the Joanna Briggs Institute critical appraisal checklist. Study screening and data extraction were conducted by three reviewers independently. Results: The electronic search retrieved 1276 titles after omitting duplicates. Twenty articles were considered for full-text review, of which six studies were included in this systematic review. The included studies evaluated a total of 173 participants with a mean age of 66.3 years. The overall mini-implant survival rate was 77.1% (95% CI: 64.7–89.5%) with a mean follow-up time of 1.79 years (range: 6 months to 3 years). Implant survival differed significantly when comparing complete and partial palatal coverage overdentures. Those with complete palatal coverage exhibited less bone loss overall compared to partial coverage overdentures. Participants of all studies reported an increase in the quality of life and in satisfaction after rehabilitation treatment with MDIs. Conclusions: The survival rate of mini-implants retaining an overdenture in the maxilla was observed to be lower than the values reported for traditional implants in the literature. Improvements were observed in all aspects in terms of patient satisfaction, quality of life, oromyofunction, and articulation after the treatment.

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What is the impact of bisphosphonate therapy upon dental implant survival? A systematic review and meta-analysis

Clinical Oral Implants Research ◽

10.1111/clr.12526 ◽

2014 ◽

Vol 27 (2) ◽

pp. e38-e46 ◽

Cited By ~ 39

Author(s):

Javier Ata-Ali ◽

Fadi Ata-Ali ◽

David Peñarrocha-Oltra ◽

Pablo Galindo-Moreno

Keyword(s):

Systematic Review ◽

Dental Implant ◽

Meta Analysis ◽

Bisphosphonate Therapy ◽

Implant Survival ◽

The Impact

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Long-term Short Implants Performance: Systematic Review and Meta-Analysis of the Essential Assessment Parameters

Brazilian Dental Journal ◽

10.1590/0103-6440201300265 ◽

2015 ◽

Vol 26 (4) ◽

pp. 325-336 ◽

Cited By ~ 12

Author(s):

Thais Marques Simek Vega Gonçalves ◽

Sergio Bortolini ◽

Matteo Martinolli ◽

Bruna Fernandes Moreira Alfenas ◽

Daiane Cristina Peruzzo ◽

...

Keyword(s):

Systematic Review ◽

Survival Rate ◽

Clinical Performance ◽

Meta Analysis ◽

Implant Failure ◽

Cochrane Library ◽

Implant Survival ◽

Implant Survival Rate ◽

Short Implants

<p>Lack of standard criteria in the outcome assessment makes it difficult to draw conclusions on the clinical performance of short implants and, under these circumstances, determine the reasons for implant failure. This study evaluated, through a systematic review of the literature and meta-analysis, the essential parameters required to assess the long-term clinical performance of short and extra-short implants. Electronic databases (Pubmed-MEDLINE, Cochrane Library Database, Embase, and Lilacs) were searched by two independent reviewers, without language limitation, to identify eligible papers. References from the selected articles were also reviewed. The review included clinical trials involving short dental implants placed in humans, published between January 2000 and March 2014, which described the parameters applied for outcome's measurements and provided data on survival rates. Thirteen methodologically acceptable studies were selected and 24 parameters were identified. The most frequent parameters assessed were the marginal bone loss and the cumulative implant survival rate, followed by implant failure rate and biological complications such as bleeding on probing and probing pocket depths. Only cumulative implant survival rate data allows meta-analysis revealing a positive effect size (from 0.052 (fixed) to 0.042 (random)), which means that short implant appears to be a successful treatment option. Mechanical complications and crown-to-implant (C/I) ratio measurement were also commonly described, however, considering the available evidence; no strong conclusions could be drawn since different methods were used to assess each parameter. By means of this literature review, a standard evaluation scheme is proposed, being helpful to regiment further investigations and comparisons on future studies.</p>

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Nano(Neuro)Medicinal Interventions for Neurodegenerative Disorders: A Meta-Analysis of Concurrent Challenges and

Nanotechnology and Drug Delivery, Volume Two ◽

10.1201/b19976-15 ◽

2016 ◽

pp. 297-336

Keyword(s):

Neurodegenerative Disorders ◽

Meta Analysis

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Association between surgeon grade and implant survival following hip and knee replacement: a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2020-047882 ◽

2021 ◽

Vol 11 (11) ◽

pp. e047882

Author(s):

Timothy J Fowler ◽

Alex L Aquilina ◽

Ashley W Blom ◽

Adrian Sayers ◽

Michael R Whitehouse

Keyword(s):

Systematic Review ◽

Knee Replacement ◽

Revision Rate ◽

Meta Analysis ◽

Secondary Outcome ◽

Published Data ◽

Implant Survival ◽

Knee Replacements ◽

Orthopaedic Training ◽

Training Programmes

ObjectiveTo investigate the association between surgeon grade (trainee vs consultant) and implant survival following primary hip and knee replacement.DesignA systematic review and meta-analysis of observational studies.Data sourcesMEDLINE and Embase from inception to 6 October 2021.SettingUnits performing primary hip and/or knee replacements since 1990.ParticipantsAdult patients undergoing either a primary hip or knee replacement, predominantly for osteoarthritis.InterventionWhether the surgeon recorded as performing the procedure was a trainee or not.Primary and secondary outcome measuresThe primary outcome was net implant survival reported as a Kaplan-Meier survival estimate. The secondary outcome was crude revision rate. Both outcomes were reported according to surgeon grade.ResultsNine cohort studies capturing 4066 total hip replacements (THRs), 936 total knee replacements (TKRs) and 1357 unicompartmental knee replacements (UKRs) were included (5 THR studies, 2 TKR studies and 2 UKR studies). The pooled net implant survival estimates for THRs at 5 years were 97.9% (95% CI 96.6% to 99.2%) for trainees and 98.1% (95% CI 97.1% to 99.2%) for consultants. The relative risk of revision of THRs at 5 and 10 years was 0.88 (95% CI 0.46 to 1.70) and 0.68 (95% CI 0.37 to 1.26), respectively. For TKRs, the net implant survival estimates at 10 years were 96.2% (95% CI 94.0% to 98.4%) for trainees and 95.1% (95% CI 93.0% to 97.2%) for consultants. We report a narrative summary of UKR outcomes.ConclusionsThere is no strong evidence in the existing literature that trainee surgeons have worse outcomes compared with consultants, in terms of the net survival or crude revision rate of hip and knee replacements at 5–10 years follow-up. These findings are limited by the quality of the existing published data and are applicable to countries with established orthopaedic training programmes.PROSPERO registration numberCRD42019150494.

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P2-247: EEG THETA OSCILLATIONS AS A POTENTIAL BIOMARKER FOR EXECUTIVE DYSFUNCTION IN NEURODEGENERATIVE DISORDERS: A SYSTEMATIC REVIEW WITH META-ANALYSIS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.934 ◽

2006 ◽

Vol 14 (7S_Part_14) ◽

pp. P768-P768

Author(s):

Lenka J. Wichmann ◽

Juan Francisco Flores-Vazquez ◽

Mengxi Huang ◽

Ana Luisa Sosa-Ortíz ◽

André Aleman ◽

...

Keyword(s):

Systematic Review ◽

Neurodegenerative Disorders ◽

Meta Analysis ◽

Executive Dysfunction ◽

Theta Oscillations ◽

Potential Biomarker

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Dental implants in immunocompromised patients: a systematic review and meta-analysis

International Journal of Implant Dentistry ◽

10.1186/s40729-019-0191-5 ◽

2019 ◽

Vol 5 (1) ◽

Cited By ~ 5

Author(s):

Fabian Duttenhoefer ◽

Marc Anton Fuessinger ◽

Yasmin Beckmann ◽

Rainer Schmelzeisen ◽

Knut A. Groetz ◽

...

Keyword(s):

Systematic Review ◽

Dental Implant ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Implant Failure ◽

Immunocompromised Patients ◽

Implant Survival ◽

Life Saving ◽

Impaired Health ◽

The Cochrane Collaboration

Abstract Objective Impaired health conditions and related lack of adequate host healing are among the most important conditions that account for dental implant failure. Today clinicians face an increasing number of immunocompromised patients requesting implant-based rehabilitation. To provide clinical evidence for prospective decision-making, the aim of this systematic review and meta-analysis was to analyse the influence of immunodeficiency on dental implant survival. Methods The study was conducted according to the PRISMA Statement and the principles of the Cochrane Collaboration. MEDLINE and Web of Science were searched. Results were calculated by the pooled incidence of implant loss. Reported odds ratios (OR) from fully adjusted models were preferred. Distinct risk estimates were synthesised with 95% confidence intervals. Results A total of 62 publications including 1751 endosseous implants placed in immunocompromised patients were included. For the follow-up of 24 months and longer, the mean survival rate of implants in patients with HIV was 93.1%, chemotherapy was 98.8%, autoimmune disease was 88.75%, after organ transplantation was 100%. Crohn’s disease showed a significant effect on early implant failure and resulted in increased, however not significant, implant loss. Conclusion No significant effect of immunocompromised conditions on implant survival was detectable. Implant-based therapy in immunocompromised patients should not aggravate the general morbidity and must not interfere in life-saving therapies. A careful risk stratification prior implant therapy is fundamental. To further decipher the role of immunosuppression on dental implantology, more data from controlled and randomised studies are needed.

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