The Use of Bandage Contact Lens for Epithelial Healing in Corneal Epithelial Defect

2020 ◽  
Vol 28 (1) ◽  
pp. 3
Author(s):  
Umar Mardianto ◽  
Miratasya Zulkarnaen
Keyword(s):  
Contact Lens ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Bandage Contact Lens ◽  
Corneal Epithelial Defect ◽  
Epithelial Healing

scholarly journals Comparison of the Effect of Removing Bandage Contact Lens on the Days 3 and 5 Following Photorefractive  Keratectomy

2021 ◽  
Author(s):  
Seyed-Hashem Daryabari ◽  
Khosrow Jadidi ◽  
Seyed Aliasghar Mosavi ◽  
Mostafa Naderi
Keyword(s):  
Contact Lens ◽  
Mixed Model ◽  
Major Complication ◽  
Corneal Epithelial ◽  
Mixed Model Analysis ◽  
Bandage Contact Lens ◽  
Corneal Epithelial Defect ◽  
Group 2 ◽  
The Right ◽  
Group 1

Abstract AIM: To compare the outcomes of removing bandage contact lens (BCL) on days 3and 5 after photorefractive keratectomy (PRK).Methods: One hundred patients underwent PRK (totally 200 eyes) were enrolled in the present study. The subjects were assigned to two groups. BCL removal was performed in group 1 on the day 3 after PRK from the right eye, but the removal in the group 2 was performed 5 days after the surgery from the left eye. Then, data obtained from both groups were compared. To evaluate complications, the subjects underwent slit-lamp examination in all visits.Results: Filamentary keratitis (FK) was observed in one eye in both groups. The frequency of haze was higherin group 1; however, it was not significant between two group. Using mixed model analysis, significant differences were observed in the rate of complications as well as pain and eye discomfort scores between the groups (P <0.05). No major complication was reported.Conclusion: Majority of post PRK corneal epithelial defect is healed on day 3. However, keeping BCL for 5 days postoperatively, instead of the three days produces slightly lower rate of total complication.

scholarly journals Crosslinking kezelés hatása a szaruhártya hámosodására

2017 ◽  
Vol 158 (10) ◽  
pp. 376-379
Author(s):  
Andrea Gyenes ◽  
Nóra Szentmáry ◽  
Gábor Tóth ◽  
Huba Kiss ◽  
Csaba Szekrényesi ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Observation Time ◽  
Test Results ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Fluorescein Staining ◽  
Time Points ◽  
Significant Difference ◽  
Epithelial Healing

Abstract: Introduction and aim: To analyse the effect of crosslinking (CXL) on corneal epithelial healing. Patients and method: 39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients. These data were compared using chi-quadrat test. Results: Following crosslinking, epithelial closure occured within 3, following PRK within 4 days. In the area of epithelial erosion 45 and 69 hours after CXL or PRK treatment statistically significant difference (p = 0.005 and p<0.001) was verified. Conclusion: Our results show beneficial effect of crosslinking on corneal epithelial healing. Orv. Hetil., 2017, 158(10), 376–379.

Severe Corneal Complications Associated With Corneal Lubricant Used During Surgery

2017 ◽  
Vol 1 (3) ◽  
pp. 187-190
Author(s):  
Andrew C. Lee ◽  
E. Mitchel Opremcak ◽  
Christiane Hunt ◽  
Juan A. Astruc ◽  
Brian Toussaint ◽  
...  
Keyword(s):  
Treatment Method ◽  
The United States ◽  
Posterior Segment ◽  
Epithelial Defect ◽  
Chemical Burns ◽  
Corneal Epithelial ◽  
Corneal Injury ◽  
Corneal Epithelial Defect ◽  
Time Period ◽  
Litmus Paper

Purpose: To present a series of cases of corneal chemical burns associated with the use of likely improperly buffered corneal lubricant gel, Goniovisc, during uncomplicated, posterior segment surgery. Methods: Cases of postoperative corneal complications following surgeries in which Goniovisc was used were collected from 6 retina practices across the United States between January and August 2016. The preoperative diagnosis, type of procedure, postoperative day 1 corneal findings, treatment method, and time to resolution of the corneal irregularity were recorded. pH testing of Goniovisc lots from this time period was performed using Hydrion litmus paper. Results: A total of 157 eyes of 156 patients were found to have corneal complications following relatively simple posterior segment surgeries in which Goniovisc was used. Findings included one or more of the following: corneal epithelial defect (84% of cases), Descemet folds (34%), stromal edema (14%), and superficial punctate keratitis (3%). Time to resolution ranged from 2 to 90 days (mean, 12 days; median, 7 days). Treatment methods included artificial tears (37%), bandage contact lens (28%), antibiotic drops (17%), antibiotic ointment (16%), and patching (9%). Two cases were treated with amniotic membrane grafts. One case required a penetrating keratoplasty due to an old laser-assisted in situ keratomileusis (LASIK) flap with a nonhealing epithelial defect that scarred significantly. Litmus testing of Goniovisc lots from this time period revealed a pH of 4 to 5. Conclusion: Chemical burns secondary to improperly buffered corneal lubricant solution should be considered in the differential when corneal injury is encountered following posterior segment surgery.

scholarly journals Subconjunctival Injection of Transdifferentiated Oral Mucosal Epithelial Cells for Limbal Stem Cell Deficiency in Rats

2020 ◽  
pp. 002215542098007
Author(s):  
Yu-Ting Xiao ◽  
Hua-Tao Xie ◽  
Xin Liu ◽  
Chao-Ye Duan ◽  
Jing-Yu Qu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Pigment Epithelium ◽  
Limbal Stem Cell Deficiency ◽  
Subconjunctival Injection ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Limbal Stem Cell

Rat limbal niche cells (LNCs) have been proven to induce transdifferentiation of oral mucosal epithelial cells (OMECs) into corneal epithelial-like cells termed transdifferentiated oral mucosal epithelial cells (T-OMECs). This investigation aimed to evaluate the effect of subconjunctival T-OMEC injections on alkali-induced limbal stem cell deficiency (LSCD) in rats. LNCs were cocultured with OMECs in the Transwell system to obtain T-OMECs, with NIH-3T3 cells serving as a control. Subconjunctival injection of single T-OMEC or OMEC suspension was performed immediately after corneal alkali injury. T-OMECs were prelabeled with the fluorescent dye CM-DiI in vitro and tracked in vivo. Corneal epithelial defect, opacity, and neovascularization were quantitatively analyzed. The degree of corneal epithelial defect (from day 1 onward), opacity (from day 5 onward), and neovascularization (from day 2 onward) was significantly less in the T-OMEC group than in the OMEC group. Cytokeratin 12 (CK12), pigment epithelium–derived factor, and soluble fms-like tyrosine kinase-1 were expressed at a higher rate following T-OMEC injection. Some CM-DiI-labeled cells were found to be coexpressed with CK12, Pax6, and ΔNp63α in the corneal epithelium after subconjunctival injection. Subconjunctival injection of T-OMECs prevents conjunctival invasion and maintains a normal corneal phenotype, which might be a novel strategy in the treatment of LSCD:

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