scholarly journals “Targeted” prophylaxis: Impact of rectal swab culture-directed prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy

2017 ◽  
Vol 58 (5) ◽  
pp. 365 ◽  
Author(s):  
Prabhjot Singh ◽  
Ashish Kumar ◽  
Siddharth Yadav ◽  
Lok Prakash ◽  
Brusabhanu Nayak ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Rectal Swab ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Ultrasound Guided

scholarly journals Does The Use Of Povidone Iodine Suppository Decrease The Infective Complications Of TRUS Guided Prostate Biopsies? A Randomized Prospective Study

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M S Abdulbaki ◽  
A Emam ◽  
M Badawy ◽  
H S Shaker
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Povidone Iodine ◽  
Rectal Swab ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Control Group ◽  
Ultrasound Guided ◽  
Tract Infections

Abstract Purpose Trans rectal ultrasound guided prostate biopsy can lead to urinary tract infections in 3% to 11% and sepsis in 0.1% to 5% of patients. We investigated the prevalence of different organisms among rectal flora in our community, the virulence of the most prevalent one and the effect of combined standard antibiotic prophylaxis with the use of povidone iodine suppository prior to TRUS guided biopsy of the prostate in decreasing post biopsy infectious complications. Materials and Methods Between December 2016 and September 2017, 50 men were prospectively randomized to povidone iodine rectal cleansing (50) or no cleansing (50) before transrectal ultrasound guided prostate biopsy. Rectal swab cultures, urinalaysis, urine cultures, total leukocytic count and CRP were obtained before transrectal ultrasound guided prostate biopsy. Patients received ciprofloxacin prophylaxis and attended at 1 week follow up visit. Urinalaysis, urine cultures, total leukocytic count and CRP were obtained at follow up visit and asked about fever, UTI symptoms and examined for prostatitis and epididymo-orchitis. Results Infectious complications were observed in 5 (10%) patients, including 2 (8%) in the treatment group and 3 (12%) in the control group (p = 0.0001). No cases of sepsis were recorded. Mean increase of CRP was higher in control group (P = 0.011). 17 patients among study population had Ciprofloxacin resistant rectal organisms on rectal swab cultures (34%). Conclusion Usage of pre TRUS-Bx intrarectal povidone iodine suppository together with standard antibiotic prophylaxis with ciprofloxacin helps decrease post procedure infectious complications and proved to decrease incidence of infection among patients having ciprofloxacin resistant rectal organisms.

scholarly journals Quinolone Prophylaxis in Transrectal Ultrasound Guided Prostate Biopsy: An Eight-Year Single Center Experience

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bing-Juin Chiang ◽  
Yeong Shiau Pu ◽  
Shiu-Dong Chung ◽  
Shih-Ping Liu ◽  
Hong-Jeng Yu ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Pipemidic Acid ◽  
Ultrasound Guided ◽  
E Coli ◽  
Single Center Experience ◽  
Significant Difference ◽  
Group A ◽  
Group B

We retrospectively evaluated the efficacy of prophylaxis with pipemidic acid and levofloxacin in transrectal ultrasound guided prostate biopsy (TRUSP-Bx). From January 2002 to December 2004, patients receiving oral pipemidic acid 500 mg twice daily for three days with or without a preoperative intravenous cefazolin 1 gm injection comprised group A. Between January 2005 and December 2009, patients receiving oral levofloxacin 500 mg one hour before biopsy comprised group B. We calculated the annual febrile urinary tract infection (fUTI) rates. Patients’ characteristics, including age, prophylactic antibiotics, biopsy core numbers, pathologic results, PSA, and the spectrums and susceptibility of pathogens, were also evaluated. A total of 1313 (35.5%) patients belonged to group A, while 2381 (64.5%) patients belonged to group B. Seventy-three patients experienced postoperative infectious complications. There was a significant difference in the fUTI rate between groups A and B (3.7% versus 1.0%,P<0.001). The yearly fUTI rates varied from 0.6 to 3.9% between 2002 and 2009. Of the 73 patients with fUTI, those receiving levofloxacin prophylaxis were more likely to harbor fluoroquinolone-resistant pathogens (P<0.001).E. coliwas the most common pathogen in both groups. Levofloxacin remains effective and appears superior to pipemidic acid based prophylaxis.

scholarly journals Risk factors for infectious complications following transrectal ultrasound-guided prostate biopsy

2018 ◽  
Vol Volume 11 ◽  
pp. 1491-1497 ◽  
Author(s):  
Yu-Peng Wu ◽  
Xiao-Dong Li ◽  
Zhi-Bin Ke ◽  
Shao-Hao Chen ◽  
Ping-Zhou Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prostate Biopsy ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Ultrasound Guided

scholarly journals Addition of Ceftriaxone and Amikacin to a Ciprofloxacin plus Metronidazole Regimen for Preventing Infectious Complications of Transrectal Ultrasound-Guided Prostate Biopsy: A Randomized Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad-Hossein Izadpanahi ◽  
Kia Nouri-Mahdavi ◽  
Seyed Mahmood Majidi ◽  
Mohammad-Hatef Khorrami ◽  
Farshid Alizadeh ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Controlled Trial ◽  
Intervention Group ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Control Group ◽  
Ultrasound Guided ◽  
Prophylactic Regimen ◽  
Randomized Controlled ◽  
Group 1

Background. The objective of this study was to evaluate the efficacy of adding single doses of ceftriaxone and amikacin to a ciprofloxacin plus metronidazole regimen on the reduction of infectious complications following transrectal ultrasound-guided prostate biopsy (TRUS Bx). Materials and Methods. Four hundred and fifty patients who were candidates for TRUS Bx were divided into two groups of 225 each. The control group received ciprofloxacin 500 mg orally every 12 hours together with metronidazole 500 mg orally every 8 hours from the day prior to the procedure until the fifth postoperative day. In the second group, single doses of ceftriaxone 1 g by intravenous infusion and amikacin 5 mg/kg intramuscularly were administered 30–60 minutes before TRUS Bx in addition to the oral antimicrobials described for group 1. The incidence of infection was compared between the groups. Results. The incidence of infectious complications in the intervention group was significantly lower than that in the control group (4.6% versus 0.9%, p=0.017). Conclusion. The addition of single doses of intramuscular amikacin and intravenously infused ceftriaxone to our prophylactic regimen of ciprofloxacin plus metronidazole resulted in a statistically significant reduction of infectious complications following TRUS Bx.

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