UV-Vis Spectrophotometrical and Analytical Methodology for the Determination of Singlet Oxygen in New Antibacterials Drugs

2007 ◽  
Vol 2 ◽  
pp. 117739010700200 ◽  
Author(s):  
Tamara Zoltan ◽  
Franklin Vargas ◽  
Carla Izzo
Keyword(s):  
Reactive Oxygen Species ◽  
Singlet Oxygen ◽  
Nalidixic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inexpensive Method ◽  
Analytical Methodology ◽  
First Time

We have determined and quantified spectrophotometrically the capacity of producing reactive oxygen species (ROS) as 1O2 during the photolysis with UV-A light of 5 new synthesized naphthyl ester derivates of well-known quinolone antibacterials (nalidixic acid (1), cinoxacin (2), norfloxacin (3), ciprofloxacin (4) and enoxacin (5)). The ability of the naphthyl ester derivatives (6-10) to generate singlet oxygen were detecting and for the first time quantified by the histidine assay, a sensitive, fast and inexpensive method. The following tendency of generation of singlet oxygen was observed: compounds 7 >10 > 6 > 8 > 9 >> parent drugs 1-5.

scholarly journals Fluorophotometric Determination of Hydrogen Peroxide and Other Reactive Oxygen Species with Fluorescein Hydrazide (FH) and Its Crystal Structure

2008 ◽  
Vol 56 (7) ◽  
pp. 977-981 ◽  
Author(s):  
Ryosuke Nakahara ◽  
Tsuyoshi Fujimoto ◽  
Mitsunobu Doi ◽  
Kanako Morita ◽  
Takako Yamaguchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Reactivity of Several Reactive Oxygen Species (ROS) with the Sesquiterpene Cacalol

2008 ◽  
Vol 3 (4) ◽  
pp. 1934578X0800300
Author(s):  
Manuel Jiménez-Estrada ◽  
Ricardo Reyes-Chilpa ◽  
Arturo Navarro-Ocaña ◽  
Daniel Arrieta-Báez
Keyword(s):  
Reactive Oxygen Species ◽  
Hydroxyl Radical ◽  
Singlet Oxygen ◽  
Furan Ring ◽  
Reactive Oxygen ◽  
Antioxidant Effect ◽  
Oxygen Species ◽  
Site Reaction ◽  
Hexanedioic Acid ◽  
Antioxidant Effects

To analyze the antioxidant effects of cacalol we determined its reactivity with different reactive oxygen species (ROS). Cacalol gave rise to cacalone by a specific site reaction with a hydroxyl radical. Singlet oxygen reacted only with the double bond of the furan ring, causing its rupture. On the other hand, ozone reacted with all double bonds in cacalol affording 2-methyl-hexanedioic acid as an end product. No reaction was observed with either superoxide or hydrogen peroxide. The potential antioxidant effect of cacalol as a scavenger of hydroxyl radical and singlet oxygen could be related to its function in the plant roots.

scholarly journals Reactivity of graphene oxide with reactive oxygen species (hydroxyl radical, singlet oxygen, and superoxide anion)

2019 ◽  
Vol 6 (12) ◽  
pp. 3734-3744 ◽  
Author(s):  
Hsin-Se Hsieh ◽  
Richard G. Zepp
Keyword(s):  
Reactive Oxygen Species ◽  
Graphene Oxide ◽  
Hydroxyl Radical ◽  
Singlet Oxygen ◽  
Superoxide Anion ◽  
Reactive Oxygen ◽  
Toxic Effects ◽  
Oxygen Species ◽  
Ecological Risks

Increases in the production and applications of graphene oxide (GO), coupled with reports of its toxic effects, are raising concerns about its health and ecological risks.

Exploring environment-dependent effects of Pd nanostructures on reactive oxygen species (ROS) using electron spin resonance (ESR) technique: implications for biomedical applications

2015 ◽  
Vol 17 (38) ◽  
pp. 24937-24943 ◽  
Author(s):  
Tao Wen ◽  
Weiwei He ◽  
Yu Chong ◽  
Yi Liu ◽  
Jun-Jie Yin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Electron Spin Resonance ◽  
Singlet Oxygen ◽  
Electron Spin ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Spin Resonance ◽  
Ph Dependent

Pd nanostructures can promote the decomposition of H2O2 in a pH-dependent manner and scavenge superoxide and singlet oxygen.

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